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  • 17 Similar Profiles
Cystic Fibrosis Transmembrane Conductance Regulator Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cystic Fibrosis Medicine & Life Sciences
Endoplasmic Reticulum Medicine & Life Sciences
Genes Medicine & Life Sciences
Glycosylation Medicine & Life Sciences
Yeast Chemical Compounds
Membranes Medicine & Life Sciences

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Projects 1996 2020

Research Output 1995 2016

  • 2481 Citations
  • 28 h-Index
  • 39 Article
  • 4 Review article
  • 1 Chapter
3 Citations

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770

Gentzsch, M., Ren, H. Y., Houck, S. A., Quinney, N. L., Cholon, D. M., Sopha, P., Chaudhry, I. G., Das, J., Dokholyan, N. V., Randell, S. H. & Cyr, D. M. 2016 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 3, p. L550-L559

Research output: Research - peer-reviewArticle

Therapeutics
lumacaftor
ivacaftor
Cystic Fibrosis
Mutation
1 Citations

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Uses its C-Terminus to Regulate the A2B Adenosine Receptor

Watson, M. J., Lee, S. L., Marklew, A. J., Gilmore, R. C., Gentzsch, M., Sassano, M. F., Gray, M. A. & Tarran, R. Jun 9 2016 In : Scientific Reports. 6, 27390

Research output: Research - peer-reviewArticle

Adenosine A2B Receptors
Cystic Fibrosis Transmembrane Conductance Regulator
Purinergic P1 Receptors
Adrenergic Receptors
Actin Cytoskeleton
105 Citations

Cystic fibrosis: Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

Cholon, D. M., Quinney, N. L., Fulcher, M. L., Esther, C. R., Das, J., Dokholyan, N. V., Randell, S. H., Boucher, R. C. & Gentzsch, M. Jul 23 2014 In : Science Translational Medicine. 6, 246, 246ra96

Research output: Research - peer-reviewArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Pharmacology
ivacaftor
Therapeutics
4 Citations

The N-terminal domain allosterically regulates cleavage and activation of the epthelial sodium channel

Kota, P., Buchner, G., Chakraborty, H., Dang, Y. L., He, H., Garcia, G. J. M., Kubelka, J., Gentzsch, M., Stutts, M. J. & Dokholyan, N. V. Aug 15 2014 In : Journal of Biological Chemistry. 289, 33, p. 23029-23042 14 p.

Research output: Research - peer-reviewArticle

Epithelial Sodium Channels
Sodium Channels
Chemical activation
Peptide Hydrolases
Phosphatidylinositols
43 Citations

Allosteric modulation balances thermodynamic stability and restores function of Δf508 CFTR

Aleksandrov, A. A., Kota, P., Cui, L., Jensen, T., Alekseev, A. E., Reyes, S., He, L., Gentzsch, M., Aleksandrov, L. A., Dokholyan, N. V. & Riordan, J. R. May 25 2012 In : Journal of Molecular Biology. 419, 1-2, p. 41-60 20 p.

Research output: Research - peer-reviewArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Thermodynamics
Proline
Genetic Suppression
Transition Temperature