• 39638 Citations
  • 100 h-Index
1974 …2018
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Research Output 1974 2018

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Review article
2018
6 Citations

Targeted drug delivery to melanoma

Liu, Q., Das, M., Liu, Y. & Huang, L., Mar 1 2018, In : Advanced Drug Delivery Reviews. 127, p. 208-221 14 p.

Research output: Contribution to journalReview article

Melanoma
Pharmaceutical Preparations
Nanotechnology
Melanocytes
Skin Neoplasms
2017
19 Citations

Nanoformulations for combination or cascade anticancer therapy

Miao, L., Guo, S., Lin, C. M., Liu, Q. & Huang, L., Jun 1 2017, In : Advanced Drug Delivery Reviews. 115, p. 3-22 20 p.

Research output: Contribution to journalReview article

Nanoparticles
Pharmaceutical Preparations
Lipids
Cellular Microenvironment
Neoplasms
14 Citations

Nanomaterials for cancer immunotherapy

Song, W., Musetti, S. N. & Huang, L., Dec 1 2017, In : Biomaterials. 148, p. 16-30 15 p.

Research output: Contribution to journalReview article

Nanostructures
Nanostructured materials
Immunotherapy
Cancer Vaccines
Chemotherapy
1 Citations

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Shi, K., Haynes, M. & Huang, L., Dec 1 2017, In : Frontiers of Chemical Science and Engineering. 11, 4, p. 676-684 9 p.

Research output: Contribution to journalReview article

Cancer Vaccines
Vaccines
Immunologic Factors
Tumors
Lipids
2016
17 Citations

Current and future theranostic applications of the lipid-calcium-phosphate nanoparticle platform

Satterlee, A. B. & Huang, L., Jan 1 2016, In : Theranostics. 6, 7, p. 918-929 12 p.

Research output: Contribution to journalReview article

Nanoparticles
Lipids
Cytotoxins
Diagnostic Imaging
Single-Photon Emission-Computed Tomography
2015
56 Citations

Delivery of oligonucleotides with lipid nanoparticles

Wang, Y., Miao, L., Satterlee, A. & Huang, L., Jan 1 2015, In : Advanced Drug Delivery Reviews. 87, p. 68-80 13 p.

Research output: Contribution to journalReview article

Oligonucleotides
Nanoparticles
Lipids
Therapeutics
Drug Delivery Systems
164 Citations

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

Chen, Y., Gao, D. Y. & Huang, L., Jan 1 2015, In : Advanced Drug Delivery Reviews. 81, p. 128-141 14 p.

Research output: Contribution to journalReview article

MicroRNAs
Neoplasms
Therapeutics
Gene Expression
Small Untranslated RNA
2014
7 Citations

Hepatic RNA interference: Delivery by synthetic vectors

Haynes, M. T. & Huang, L., Feb 1 2014, In : Drug Delivery and Translational Research. 4, 1, p. 61-73 13 p.

Research output: Contribution to journalReview article

RNA Interference
Liver
RNA
Technology
Muscular Dystrophies
63 Citations

Nanoparticles containing insoluble drug for cancer therapy

Guo, S. & Huang, L., Jan 1 2014, In : Biotechnology Advances. 32, 4, p. 778-788 11 p.

Research output: Contribution to journalReview article

Nanoparticles
Drug Therapy
Pharmaceutical Preparations
Neoplasms
Drug Compounding
43 Citations

Non-viral nanocarriers for siRNA delivery in breast cancer

Zhang, J., Li, X. & Huang, L., Sep 28 2014, In : Journal of Controlled Release. 190, p. 440-450 11 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Gene Silencing
Breast Neoplasms
Carcinogenesis
Gene Knockdown Techniques
2013
9 Citations

Strategies on the nuclear-targeted delivery of genes

Yao, J., Fan, Y., Li, Y. & Huang, L., Dec 1 2013, In : Journal of Drug Targeting. 21, 10, p. 926-939 14 p.

Research output: Contribution to journalReview article

Nuclear Envelope
Cell Nucleus Active Transport
Transgenes
Genes
Genome
2012
131 Citations

Design considerations for liposomal vaccines: Influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens

Watson, D. S., Endsley, A. N. & Huang, L., Mar 16 2012, In : Vaccine. 30, 13, p. 2256-2272 17 p.

Research output: Contribution to journalReview article

Liposomes
cell-mediated immunity
Vaccines
vaccines
antigens
28 Citations

Intelligent design of multifunctional lipid-coated nanoparticle platforms for cancer therapy

Ramishetti, S. & Huang, L., Dec 1 2012, In : Therapeutic Delivery. 3, 12, p. 1429-1445 17 p.

Research output: Contribution to journalReview article

Religious Philosophies
Nanoparticles
Drug Carriers
Lipids
Neoplasms
35 Citations

Lipid-based vectors for siRNA delivery

Zhang, S., Zhi, D. & Huang, L., Nov 1 2012, In : Journal of Drug Targeting. 20, 9, p. 724-735 12 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Lipids
Particle Size
Liposomes
Organelles
2011
39 Citations

Cancer immunotherapy and nanomedicine

Sheng, W. Y. & Huang, L., Feb 1 2011, In : Pharmaceutical research. 28, 2, p. 200-214 15 p.

Research output: Contribution to journalReview article

Nanomedicine
Medical nanotechnology
Immune system
Immunotherapy
Tumors
87 Citations

Nanoparticles escaping RES and endosome: Challenges for siRNA delivery for cancer therapy

Huang, L. & Guo, S., Oct 11 2011, In : Journal of Nanomaterials. 2011, 742895.

Research output: Contribution to journalReview article

Small Interfering RNA
Nanoparticles
Polyethylene glycols
Tumors
Brushes
75 Citations

The suppressive tumor microenvironment: A challenge in cancer immunotherapy

Vasievich, E. A. & Huang, L., Jun 6 2011, In : Molecular Pharmaceutics. 8, 3, p. 635-641 7 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Immunotherapy
Neoplasms
Macrophages
Regulatory T-Lymphocytes
2009
312 Citations

Lipid-based systemic delivery of siRNA

Tseng, Y. C., Mozumdar, S. & Huang, L., Jul 25 2009, In : Advanced Drug Delivery Reviews. 61, 9, p. 721-731 11 p.

Research output: Contribution to journalReview article

RNA Interference
Small Interfering RNA
Lipids
Architectural Accessibility
Inborn Genetic Diseases
185 Citations

Nonviral methods for siRNA delivery

Gao, K. & Huang, L., Jun 1 2009, In : Molecular Pharmaceutics. 6, 3, p. 651-658 8 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Messenger RNA
Validation Studies
Genomics
RNA Interference
32 Citations

Self-assembled lipid nanomedicines for siRNA tumor targeting

Tseng, Y. C. & Huang, L., Aug 1 2009, In : Journal of Biomedical Nanotechnology. 5, 4, p. 351-363 13 p.

Research output: Contribution to journalReview article

Nanomedicine
Medical nanotechnology
Lipids
Small Interfering RNA
Tumors
2008
35 Citations

Targeted delivery of siRNA by nonviral vectors: Lessons learned from recent advances

Li, S. D. & Huang, L., Dec 2008, In : Current Opinion in Investigational Drugs. 9, 12, p. 1317-1323 7 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Inborn Genetic Diseases
RNA Interference
Oligonucleotides
Nanoparticles
44 Citations

Tumor-targeted delivery of siRNA by non-viral vector: Safe and effective cancer therapy

Chen, Y. & Huang, L., Dec 1 2008, In : Expert Opinion on Drug Delivery. 5, 12, p. 1301-1311 11 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Neoplasms
Therapeutic Uses
RNA Interference
Oncogenes
2006
297 Citations

Gene therapy progress and prospects: Non-viral gene therapy by systemic delivery

Li, S. D. & Huang, L., Sep 1 2006, In : Gene Therapy. 13, 18, p. 1313-1319 7 p.

Research output: Contribution to journalReview article

Genetic Therapy
Oligonucleotides
Genes
Plasmids
Research Personnel
24 Citations

Local Drug Delivery to Bladder Using Technology Innovations

Tyagi, P., Tyagi, S., Kaufman, J., Huang, L. & de Miguel, F., Nov 1 2006, In : Urologic Clinics of North America. 33, 4, p. 519-530 12 p.

Research output: Contribution to journalReview article

Urinary Bladder
Technology
Liposomes
Pharmaceutical Preparations
Interstitial Cystitis
65 Citations

Recent advances in intravesical drug/gene delivery

Tyagi, P., Wu, P. C., Chancellor, M., Yoshimura, N. & Huang, L., Jul 1 2006, In : Molecular Pharmaceutics. 3, 4, p. 369-379 11 p.

Research output: Contribution to journalReview article

Urinary Bladder
Pharmaceutical Preparations
Genes
Drug Administration Routes
Neurogenic Urinary Bladder
2005
136 Citations

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

Zhang, J. S., Liu, F. & Huang, L., Apr 5 2005, In : Advanced Drug Delivery Reviews. 57, 5, p. 689-698 10 p.

Research output: Contribution to journalReview article

Liposomes
Pharmacokinetics
DNA
Injections
Kupffer Cells
22 Citations

Lipid-protamine-DNA-mediated antigen delivery

Vangasseri, D. P., Han, S. J. & Huang, L., Oct 2005, In : Current Drug Delivery. 2, 4, p. 401-406 6 p.

Research output: Contribution to journalReview article

Protamines
Vaccines
Lipids
Antigens
Peptides
39 Citations

Non-Viral Vector as Vaccine Carrier

Chen, W. C. & Huang, L., Dec 1 2005, In : Advances in Genetics. 54, p. 315-337 23 p.

Research output: Contribution to journalReview article

Vaccines
Liposomes
Antigens
DNA Vaccines
Human Development

Recent advances in non-viral gene delivery.

Conwell, C. C. & Huang, L., Dec 1 2005, In : Advances in genetics.. 53, p. 3-18 16 p.

Research output: Contribution to journalReview article

Genes
Gene Transfer Techniques
Genetic Therapy
Medicine
Gene Expression
2003
3 Citations

Targeted gene delivery: The role of peptide nucleic acid

Liang, K. W., Liu, F. & Huang, L., 2003, In : Letters in Peptide Science. 10, 3-4, p. 161-167 7 p.

Research output: Contribution to journalReview article

Peptide Nucleic Acids
Genes
Particle Size
Particle size
Cell Nucleus Active Transport
2002
29 Citations

Codelivery of NF-ΚB decoy-related oligodeoxynucleotide improves LPD-mediated systemic gene transfer

Tan, Y., Zhang, J. S. & Huang, L., Dec 1 2002, In : Molecular Therapy. 6, 6, p. 804-812 9 p.

Research output: Contribution to journalReview article

Oligodeoxyribonucleotides
Liposomes
DNA
Genes
Transgenes
752 Citations

Gene therapy progress and prospects: Nonviral vectors

Niidome, T. & Huang, L., Jan 1 2002, In : Gene Therapy. 9, 24, p. 1647-1652 6 p.

Research output: Contribution to journalReview article

Genetic Therapy
DNA
Plasmids
Genes
Religious Philosophies
28 Citations

LPD nanoparticles--novel nonviral vector for efficient gene delivery.

Tan, Y., Whitmore, M., Li, S., Frederik, P. & Huang, L., 2002, In : Methods in molecular medicine. 69, p. 73-81 9 p.

Research output: Contribution to journalReview article

Gene Transfer Techniques
Genetic Vectors
Nanotechnology
Polyamines
Liposomes
2001
539 Citations

Nonviral vectors in the new millennium: Delivery barriers in gene transfer

Nishikawa, M. & Huang, L., 2001, In : Human Gene Therapy. 12, 8, p. 861-870 10 p.

Research output: Contribution to journalReview article

Genes
Inborn Genetic Diseases
Electroporation
Blood Circulation
Endosomes
17 Citations

Systemic administration of naked DNA: gene transfer to skeletal muscle.

Liu, F., Liang, K. W. & Huang, L., Aug 2001, In : Mol Interv. 1, 3, p. 168-172 5 p.

Research output: Contribution to journalReview article

Gene transfer
Muscle
Skeletal Muscle
Muscles
DNA
2000
239 Citations

Structure and function of lipid-DNA complexes for gene delivery

Chesnoy, S. & Huang, L., 2000, In : Annual Review of Biophysics and Biomolecular Structure. 29, p. 27-47 21 p.

Research output: Contribution to journalReview article

Lipids
DNA
Genes
Transfection
Gene transfer
1999
9 Citations

DNA condensed by polycations and lipids for gene transfer

Chesnoy, S. & Huang, L., Jan 1999, In : S.T.P. Pharma Sciences. 9, 1, p. 5-12 8 p.

Research output: Contribution to journalReview article

Liposomes
Lipids
DNA
Genes
Synthetic Genes
1998
33 Citations

Liposome-based gene therapy

Tseng, W. C. & Huang, L., Aug 1 1998, In : Pharmaceutical Science and Technology Today. 1, 5, p. 206-213 8 p.

Research output: Contribution to journalReview article

Liposomes
Genetic Therapy
Transfection
Plasmids
Nuclear Localization Signals
1997
168 Citations

Lipidic vector systems for gene transfer

Lee, R. J. & Huang, L., 1997, In : Critical Reviews in Therapeutic Drug Carrier Systems. 14, 2, p. 173-206 34 p.

Research output: Contribution to journalReview article

Liposomes
Genes
DNA
Poisons
Genetic Therapy
1996
19 Citations

Lipidic supramolecular assemblies for gene transfer

Li, S. & Huang, L., Jan 1 1996, In : Journal of Liposome Research. 6, 3, p. 589-608 20 p.

Research output: Contribution to journalReview article

Polylysine
Liposomes
Intravenous Administration
Genes
Transfection
1995
626 Citations

Cationic liposome-mediated gene transfer

Gao, X. & Huang, L., 1995, In : Gene Therapy. 2, 10, p. 710-722 13 p.

Research output: Contribution to journalReview article

Liposomes
Genes
Genetic Therapy
Safety
DNA
48 Citations

Interaction of PEG-phospholipid conjugates with phospholipid: implications in liposomal drug delivery

Bedu-Addo, F. K. & Huang, L., Jan 1 1995, In : Advanced Drug Delivery Reviews. 16, 2-3, p. 235-247 13 p.

Research output: Contribution to journalReview article

Phospholipids
Phosphatidylcholines
Pharmaceutical Preparations
Cholesterol
Micelles
6 Citations

Targeted Immunoliposomes: Potential Role in the Delivery of Cytotoxic Drugs

Mori, A. & Huang, L., 1995, In : Clinical Immunotherapeutics. 3, 3, p. 227-240 14 p.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Liposomes
Oligonucleotides
Plasmids
Pharmacokinetics
7 Citations

The use of liposomes in the therapy of liver disease

Yao, T., Huang, L. & Zern, M. A., Dec 5 1995, In : Advanced Drug Delivery Reviews. 17, 3, p. 239-246 8 p.

Research output: Contribution to journalReview article

Liposomes
Physiology
Chemical modification
Biodegradation
Liver
1992
327 Citations

Phosphatodylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications

Litzinger, D. C. & Huang, L., Aug 14 1992, In : BBA - Reviews on Biomembranes. 1113, 2, p. 201-227 27 p.

Research output: Contribution to journalReview article

Phosphatidylethanolamines
Drug Carriers
Structural Models
Cytarabine
Lipid Bilayers