Research Output 1974 2018

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Review article
2018
4 Citations

Targeted drug delivery to melanoma

Liu, Q., Das, M., Liu, Y. & Huang, L. Mar 1 2018 In : Advanced Drug Delivery Reviews. 127, p. 208-221 14 p.

Research output: Contribution to journalReview article

2017
10 Citations

Nanoformulations for combination or cascade anticancer therapy

Miao, L., Guo, S., Lin, C. M., Liu, Q. & Huang, L. Jun 1 2017 In : Advanced Drug Delivery Reviews. 115, p. 3-22 20 p.

Research output: Contribution to journalReview article

Enzyme inhibition
Oncology
Tumor Microenvironment
Multiple Drug Resistance
Nanoparticles
3 Citations

Nanomaterials for cancer immunotherapy

Song, W., Musetti, S. N. & Huang, L. Dec 1 2017 In : Biomaterials. 148, p. 16-30 15 p.

Research output: Contribution to journalReview article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Shi, K., Haynes, M. & Huang, L. Dec 1 2017 In : Frontiers of Chemical Science and Engineering. 11, 4, p. 676-684 9 p.

Research output: Contribution to journalReview article

2016
15 Citations

Current and future theranostic applications of the lipid-calcium-phosphate nanoparticle platform

Satterlee, A. B. & Huang, L. Jan 1 2016 In : Theranostics. 6, 7, p. 918-929 12 p.

Research output: Contribution to journalReview article

Nanoparticles
Lipids
Cytotoxins
Diagnostic Imaging
Single-Photon Emission-Computed Tomography
2015
46 Citations

Delivery of oligonucleotides with lipid nanoparticles

Wang, Y., Miao, L., Satterlee, A. & Huang, L. Jan 1 2015 In : Advanced Drug Delivery Reviews. 87, p. 68-80 13 p.

Research output: Contribution to journalReview article

Oligonucleotides
Nanoparticles
Lipids
Therapeutics
Drug Delivery Systems
127 Citations

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

Chen, Y., Gao, D. Y. & Huang, L. Jan 1 2015 In : Advanced Drug Delivery Reviews. 81, p. 128-141 14 p.

Research output: Contribution to journalReview article

MicroRNAs
Neoplasms
Therapeutics
Gene Expression
Small Untranslated RNA
2014
7 Citations

Hepatic RNA interference: Delivery by synthetic vectors

Haynes, M. T. & Huang, L. Feb 1 2014 In : Drug Delivery and Translational Research. 4, 1, p. 61-73 13 p.

Research output: Contribution to journalReview article

RNA Interference
Liver
RNA
Technology
Muscular Dystrophies
54 Citations

Nanoparticles containing insoluble drug for cancer therapy

Guo, S. & Huang, L. Jan 1 2014 In : Biotechnology Advances. 32, 4, p. 778-788 11 p.

Research output: Contribution to journalReview article

Nanoparticles
Drug Therapy
Neoplasms
Drug Compounding
Pharmaceutical Preparations
36 Citations

Non-viral nanocarriers for siRNA delivery in breast cancer

Zhang, J., Li, X. & Huang, L. Sep 28 2014 In : Journal of Controlled Release. 190, p. 440-450 11 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Gene Silencing
Breast Neoplasms
Carcinogenesis
Gene Knockdown Techniques
2013
7 Citations

Strategies on the nuclear-targeted delivery of genes

Yao, J., Fan, Y., Li, Y. & Huang, L. Dec 1 2013 In : Journal of Drug Targeting. 21, 10, p. 926-939 14 p.

Research output: Contribution to journalReview article

Nuclear Envelope
Cell Nucleus Active Transport
Transgenes
Genes
Genome
2012
119 Citations

Design considerations for liposomal vaccines: Influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens

Watson, D. S., Endsley, A. N. & Huang, L. Mar 16 2012 In : Vaccine. 30, 13, p. 2256-2272 17 p.

Research output: Contribution to journalReview article

Liposomes
cell-mediated immunity
Vaccines
vaccines
antigens
26 Citations

Intelligent design of multifunctional lipid-coated nanoparticle platforms for cancer therapy

Ramishetti, S. & Huang, L. Dec 2012 In : Therapeutic Delivery. 3, 12, p. 1429-1445 17 p.

Research output: Contribution to journalReview article

Religious Philosophies
Nanoparticles
Drug Carriers
Lipids
Neoplasms
34 Citations

Lipid-based vectors for siRNA delivery

Zhang, S., Zhi, D. & Huang, L. Nov 1 2012 In : Journal of Drug Targeting. 20, 9, p. 724-735 12 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Lipids
Particle Size
Liposomes
Organelles
2011
34 Citations

Cancer immunotherapy and nanomedicine

Sheng, W. Y. & Huang, L. Feb 1 2011 In : Pharmaceutical Research. 28, 2, p. 200-214 15 p.

Research output: Contribution to journalReview article

Nanomedicine
Medical nanotechnology
Immune system
Immunotherapy
Tumors
79 Citations

Nanoparticles escaping RES and endosome: Challenges for siRNA delivery for cancer therapy

Huang, L. & Guo, S. Oct 11 2011 In : Journal of Nanomaterials. 2011, 742895

Research output: Contribution to journalReview article

Small Interfering RNA
Nanoparticles
Polyethylene glycols
Tumors
Brushes
69 Citations

The suppressive tumor microenvironment: A challenge in cancer immunotherapy

Vasievich, E. A. & Huang, L. Jun 6 2011 In : Molecular Pharmaceutics. 8, 3, p. 635-641 7 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Immunotherapy
Neoplasms
Macrophages
Regulatory T-Lymphocytes
2009
298 Citations

Lipid-based systemic delivery of siRNA

Tseng, Y. C., Mozumdar, S. & Huang, L. Jul 25 2009 In : Advanced Drug Delivery Reviews. 61, 9, p. 721-731 11 p.

Research output: Contribution to journalReview article

RNA Interference
Small Interfering RNA
Lipids
Architectural Accessibility
Inborn Genetic Diseases
175 Citations

Nonviral methods for siRNA delivery

Gao, K. & Huang, L. Jun 1 2009 In : Molecular Pharmaceutics. 6, 3, p. 651-658 8 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Messenger RNA
Validation Studies
Genomics
RNA Interference
32 Citations

Self-assembled lipid nanomedicines for siRNA tumor targeting

Tseng, Y. C. & Huang, L. Aug 1 2009 In : Journal of Biomedical Nanotechnology. 5, 4, p. 351-363 13 p.

Research output: Contribution to journalReview article

Nanomedicine
Medical nanotechnology
Lipids
Small Interfering RNA
Tumors
2008
34 Citations

Targeted delivery of siRNA by nonviral vectors: Lessons learned from recent advances

Li, S. D. & Huang, L. Dec 2008 In : Current Opinion in Investigational Drugs. 9, 12, p. 1317-1323 7 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Inborn Genetic Diseases
RNA Interference
Oligonucleotides
Nanoparticles
43 Citations

Tumor-targeted delivery of siRNA by non-viral vector: Safe and effective cancer therapy

Chen, Y. & Huang, L. Dec 1 2008 In : Expert Opinion on Drug Delivery. 5, 12, p. 1301-1311 11 p.

Research output: Contribution to journalReview article

Small Interfering RNA
Neoplasms
Therapeutic Uses
RNA Interference
Oncogenes
2006
286 Citations

Gene therapy progress and prospects: Non-viral gene therapy by systemic delivery

Li, S. D. & Huang, L. Sep 1 2006 In : Gene Therapy. 13, 18, p. 1313-1319 7 p.

Research output: Contribution to journalReview article

Genetic Therapy
Oligonucleotides
Genes
Plasmids
Research Personnel
22 Citations

Local Drug Delivery to Bladder Using Technology Innovations

Tyagi, P., Tyagi, S., Kaufman, J., Huang, L. & de Miguel, F. Nov 1 2006 In : Urologic Clinics of North America. 33, 4, p. 519-530 12 p.

Research output: Contribution to journalReview article

Urinary Bladder
Technology
Liposomes
Pharmaceutical Preparations
Interstitial Cystitis
63 Citations

Recent advances in intravesical drug/gene delivery

Tyagi, P., Wu, P. C., Chancellor, M., Yoshimura, N. & Huang, L. Jul 2006 In : Molecular Pharmaceutics. 3, 4, p. 369-379 11 p.

Research output: Contribution to journalReview article

Urinary Bladder
Pharmaceutical Preparations
Genes
Drug Administration Routes
Neurogenic Urinary Bladder
2005
132 Citations

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

Zhang, J. S., Liu, F. & Huang, L. Apr 5 2005 In : Advanced Drug Delivery Reviews. 57, 5, p. 689-698 10 p.

Research output: Contribution to journalReview article

Liposomes
Pharmacokinetics
DNA
Injections
Kupffer Cells
22 Citations

Lipid-protamine-DNA-mediated antigen delivery

Vangasseri, D. P., Han, S. J. & Huang, L. Oct 2005 In : Current Drug Delivery. 2, 4, p. 401-406 6 p.

Research output: Contribution to journalReview article

Protamines
Vaccines
Lipids
Antigens
Peptides
38 Citations

Non-Viral Vector as Vaccine Carrier

Chen, W. C. & Huang, L. Dec 1 2005 In : Advances in Genetics. 54, p. 315-337 23 p.

Research output: Contribution to journalReview article

Vaccines
Liposomes
Antigens
DNA Vaccines
Human Development
20 Citations

Recent advances in non-viral gene delivery.

Conwell, C. C. & Huang, L. Dec 1 2005 In : Advances in genetics.. 53, p. 3-18 16 p.

Research output: Contribution to journalReview article

Genes
Gene Transfer Techniques
Genetic Therapy
Medicine
Gene Expression
2003
3 Citations

Targeted gene delivery: The role of peptide nucleic acid

Liang, K. W., Liu, F. & Huang, L. 2003 In : Letters in Peptide Science. 10, 3-4, p. 161-167 7 p.

Research output: Contribution to journalReview article

Peptide Nucleic Acids
Genes
Particle Size
Particle size
Cell Nucleus Active Transport
2002
28 Citations

Codelivery of NF-ΚB decoy-related oligodeoxynucleotide improves LPD-mediated systemic gene transfer

Tan, Y., Zhang, J. S. & Huang, L. Dec 1 2002 In : Molecular Therapy. 6, 6, p. 804-812 9 p.

Research output: Contribution to journalReview article

Oligodeoxyribonucleotides
Liposomes
DNA
Genes
Transgenes
731 Citations

Gene therapy progress and prospects: Nonviral vectors

Niidome, T. & Huang, L. Jan 1 2002 In : Gene Therapy. 9, 24, p. 1647-1652 6 p.

Research output: Contribution to journalReview article

Genetic Therapy
DNA
Plasmids
Genes
Religious Philosophies
27 Citations

LPD nanoparticles--novel nonviral vector for efficient gene delivery.

Tan, Y., Whitmore, M., Li, S., Frederik, P. & Huang, L. 2002 In : Methods in molecular medicine. 69, p. 73-81 9 p.

Research output: Contribution to journalReview article

Gene Transfer Techniques
Genetic Vectors
Nanotechnology
Polyamines
Liposomes
2001
531 Citations

Nonviral vectors in the new millennium: Delivery barriers in gene transfer

Nishikawa, M. & Huang, L. 2001 In : Human Gene Therapy. 12, 8, p. 861-870 10 p.

Research output: Contribution to journalReview article

Genes
Inborn Genetic Diseases
Electroporation
Blood Circulation
Endosomes
16 Citations

Systemic administration of naked DNA: gene transfer to skeletal muscle.

Liu, F., Liang, K. W. & Huang, L. Aug 2001 In : Mol Interv. 1, 3, p. 168-172 5 p.

Research output: Contribution to journalReview article

Gene transfer
Muscle
Skeletal Muscle
Muscles
DNA
2000
237 Citations

Structure and function of lipid-DNA complexes for gene delivery

Chesnoy, S. & Huang, L. 2000 In : Annual Review of Biophysics and Biomolecular Structure. 29, p. 27-47 21 p.

Research output: Contribution to journalReview article

Lipids
DNA
Genes
Transfection
Gene transfer
1999
9 Citations

DNA condensed by polycations and lipids for gene transfer

Chesnoy, S. & Huang, L. Jan 1999 In : S.T.P. Pharma Sciences. 9, 1, p. 5-12 8 p.

Research output: Contribution to journalReview article

Liposomes
Lipids
DNA
Genes
Synthetic Genes
1998
32 Citations

Liposome-based gene therapy

Tseng, W. C. & Huang, L. Aug 1 1998 In : Pharmaceutical Science and Technology Today. 1, 5, p. 206-213 8 p.

Research output: Contribution to journalReview article

Liposomes
Genetic Therapy
Transfection
Plasmids
Nuclear Localization Signals
1997
164 Citations

Lipidic vector systems for gene transfer

Lee, R. J. & Huang, L. 1997 In : Critical Reviews in Therapeutic Drug Carrier Systems. 14, 2, p. 173-206 34 p.

Research output: Contribution to journalReview article

Liposomes
Genes
DNA
Poisons
Genetic Therapy
1996
19 Citations

Lipidic supramolecular assemblies for gene transfer

Li, S. & Huang, L. Jan 1 1996 In : Journal of Liposome Research. 6, 3, p. 589-608 20 p.

Research output: Contribution to journalReview article

Polylysine
Liposomes
Intravenous Administration
Genes
Transfection
1995
618 Citations

Cationic liposome-mediated gene transfer

Gao, X. & Huang, L. 1995 In : Gene Therapy. 2, 10, p. 710-722 13 p.

Research output: Contribution to journalReview article

Liposomes
Genes
Genetic Therapy
Safety
DNA
47 Citations

Interaction of PEG-phospholipid conjugates with phospholipid: implications in liposomal drug delivery

Bedu-Addo, F. K. & Huang, L. Jan 1 1995 In : Advanced Drug Delivery Reviews. 16, 2-3, p. 235-247 13 p.

Research output: Contribution to journalReview article

Phospholipids
Phosphatidylcholines
Pharmaceutical Preparations
Cholesterol
Micelles
6 Citations

Targeted Immunoliposomes: Potential Role in the Delivery of Cytotoxic Drugs

Mori, A. & Huang, L. 1995 In : Clinical Immunotherapeutics. 3, 3, p. 227-240 14 p.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Liposomes
Oligonucleotides
Plasmids
Pharmacokinetics
7 Citations

The use of liposomes in the therapy of liver disease

Yao, T., Huang, L. & Zern, M. A. Dec 5 1995 In : Advanced Drug Delivery Reviews. 17, 3, p. 239-246 8 p.

Research output: Contribution to journalReview article

Liposomes
Physiology
Chemical modification
Biodegradation
Liver
1992
317 Citations

Phosphatodylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications

Litzinger, D. C. & Huang, L. Aug 14 1992 In : BBA - Reviews on Biomembranes. 1113, 2, p. 201-227 27 p.

Research output: Contribution to journalReview article

Phosphatidylethanolamines
Drug Carriers
Structural Models
Cytarabine
Lipid Bilayers