Research Output 1974 2017

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2017

A dosimetric model for the heterogeneous delivery of radioactive nanoparticles In vivo: A feasibility study

Satterlee, A. B., Attayek, P., Midkiff, B. & Huang, L. Mar 17 2017 In : Radiation Oncology. 12, 1, 54

Research output: Research - peer-reviewArticle

Feasibility Studies
Nanoparticles
Neoplasms
Anatomy
Radiotherapy
6 Citations

Enhancing nanoparticle accumulation and retention in desmoplastic tumors via vascular disruption for internal radiation therapy

Satterlee, A. B., Rojas, J. D., Dayton, P. A. & Huang, L. 2017 In : Theranostics. 7, 2, p. 253-269 17 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Blood Vessels
Radiotherapy
Neoplasms
Therapeutics
3 Citations
Liver Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Antigens
Peptides
9 Citations

Targeting tumor-associated fibroblasts for therapeutic delivery in desmoplastic tumors

Miao, L., Liu, Q., Lin, C. M., Luo, C., Wang, Y., Liu, L., Yin, W., Hu, S., Kim, W. Y. & Huang, L. Feb 1 2017 In : Cancer Research. 77, 3, p. 719-731 13 p.

Research output: Research - peer-reviewArticle

Neoplasms
Therapeutics
Cancer-Associated Fibroblasts
Nanoparticles
Heterografts
5 Citations

Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment

Huo, M., Zhao, Y., Satterlee, A. B., Wang, Y., Xu, Y. & Huang, L. Jan 10 2017 In : Journal of Controlled Release. 245, p. 81-94 14 p.

Research output: Research - peer-reviewArticle

Active Immunotherapy
Tumor Microenvironment
Melanoma
Neoplasms
sunitinib
2016
8 Citations

A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA

Luo, C., Miao, L., Zhao, Y., Musetti, S., Wang, Y., Shi, K. & Huang, L. Sep 1 2016 In : Biomaterials. 102, p. 239-248 10 p.

Research output: Research - peer-reviewArticle

TNF-Related Apoptosis-Inducing Ligand
Propane
Genetic Therapy
Lipids
DNA
9 Citations

Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer

Xiong, Y., Zhao, Y., Miao, L., Lin, C. M. & Huang, L. Dec 28 2016 In : Journal of Controlled Release. 244, p. 63-73 11 p.

Research output: Research - peer-reviewArticle

Metformin
Non-Small Cell Lung Carcinoma
Nanoparticles
Cisplatin
Membranes
15 Citations

Curcumin micelles remodel tumor microenvironment and enhance vaccine activity in an advanced melanoma model

Lu, Y., Miao, L., Wang, Y., Xu, Z., Zhao, Y., Shen, Y., Xiang, G. & Huang, L. Feb 1 2016 In : Molecular Therapy. 24, 2, p. 364-374 11 p.

Research output: Research - peer-reviewArticle

Curcumin
Tumor Microenvironment
Micelles
Melanoma
Vaccines
5 Citations

Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approach

Lu, Y., Wang, Y., Miao, L., Haynes, M., Xiang, G. & Huang, L. Aug 28 2016 In : Cancer Letters. 379, 1, p. 32-38 7 p.

Research output: Research - peer-reviewArticle

Nanomedicine
Melanoma
Antigens
Drug Therapy
Neoplasms
5 Citations

Local and transient gene expression primes the liver to resist cancer metastasis

Goodwin, T. J., Zhou, Y., Musetti, S. N., Liu, R. & Huang, L. Nov 9 2016 In : Science Translational Medicine. 8, 364, 364ra153

Research output: Research - peer-reviewArticle

Neoplasm Metastasis
Gene Expression
Liver
Neoplasms
Breast Neoplasms
1 Citations
Liposomes
Phospholipids
Calcium phosphate
Chain length
Lipids
15 Citations

Nanoparticle delivered VEGF-A siRNA enhances photodynamic therapy for head and neck cancer treatment

Lecaros, R. L. G., Huang, L., Lee, T. C. & Hsu, Y. C. Feb 1 2016 In : Molecular Therapy. 24, 1, p. 106-116 11 p.

Research output: Research - peer-reviewArticle

Photochemotherapy
Head and Neck Neoplasms
Nanoparticles
Vascular Endothelial Growth Factor A
Small Interfering RNA
11 Citations

PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

Zhao, Y., Wang, W., Guo, S., Wang, Y., Miao, L., Xiong, Y. & Huang, L. Jun 6 2016 In : Nature Communications. 7, 11822

Research output: Research - peer-reviewArticle

Metformin
Small Interfering RNA
lipids
delivery
nanoparticles
22 Citations

Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

Luo, C., Sun, J., Liu, D., Sun, B., Miao, L., Musetti, S., Li, J., Han, X., Du, Y., Li, L., Huang, L. & He, Z. Sep 14 2016 In : Nano Letters. 16, 9, p. 5401-5408 8 p.

Research output: Research - peer-reviewArticle

Nanosystems
Chemotherapy
Prodrugs
Sulfides
Paclitaxel
8 Citations

Sigma receptor-mediated targeted delivery of anti-angiogenic multifunctional nanodrugs for combination tumor therapy

Li, Y., Wu, Y., Huang, L., Miao, L., Zhou, J., Satterlee, A. B. & Yao, J. Apr 28 2016 In : Journal of Controlled Release. 228, p. 107-119 13 p.

Research output: Research - peer-reviewArticle

sigma Receptors
Low Molecular Weight Heparin
Neoplasms
Therapeutics
Anticoagulants
15 Citations

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

Miao, L., Newby, J. M., Lin, C. M., Zhang, L., Xu, F., Kim, W. Y., Forest, M. G., Lai, S. K., Milowsky, M. I., Wobker, S. E. & Huang, L. Oct 25 2016 In : ACS Nano. 10, 10, p. 9243-9258 16 p.

Research output: Research - peer-reviewArticle

fibroblasts
vessels
tumors
nanoparticles
Fibroblasts
2015
10 Citations

A radio-theranostic nanoparticle with high specific drug loading for cancer therapy and imaging

Satterlee, A. B., Yuan, H. & Huang, L. Nov 10 2015 In : Journal of Controlled Release. 217, p. 170-182 13 p.

Research output: Research - peer-reviewArticle

Radio
Nanoparticles
Lipids
Pharmaceutical Preparations
Neoplasms
23 Citations

Exploring the tumor microenvironment with nanoparticles

Miao, L. & Huang, L. 2015 In : Cancer Treatment and Research. 166, p. 193-226 34 p.

Research output: Research - peer-reviewArticle

Tumor Microenvironment
Nanoparticles
Neoplasms
Nanotechnology
Therapeutic Uses
19 Citations

Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma

Zhao, Y., Huo, M., Xu, Z., Wang, Y. & Huang, L. Nov 1 2015 In : Biomaterials. 68, p. 54-66 13 p.

Research output: Research - peer-reviewArticle

Active Immunotherapy
Tumor Microenvironment
Nanoparticles
Melanoma
methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
30 Citations

Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment strategy for head-and-neck cancer

Chen, W. H., Lecaros, R. L. G., Tseng, Y. C., Huang, L. & Hsu, Y. C. Jan 1 2015 In : Cancer Letters. 359, 1, p. 65-74 10 p.

Research output: Research - peer-reviewArticle

Photochemotherapy
Head and Neck Neoplasms
Nanoparticles
Small Interfering RNA
Therapeutics
22 Citations

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

Miao, L., Wang, Y., Lin, C. M., Xiong, Y., Chen, N., Zhang, L., Kim, W. Y. & Huang, L. Nov 10 2015 In : Journal of Controlled Release. 217, p. 27-41 15 p.

Research output: Research - peer-reviewArticle

Tumor Microenvironment
Nanoparticles
Cisplatin
Therapeutics
Cancer-Associated Fibroblasts
10 Citations

Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells

Tang, J., Li, L., Howard, C. B., Mahler, S. M., Huang, L. & Xu, Z. P. Jul 29 2015 In : Journal of Materials Chemistry B. 3, 33, p. 6805-6812 8 p.

Research output: Research - peer-reviewArticle

Small Interfering RNA
Genes
Cells
Nanoparticles
Lipids
32 Citations

Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors

Miao, L., Lin, C. M. & Huang, L. Dec 10 2015 In : Journal of Controlled Release. 219, p. 192-204 13 p.

Research output: Research - peer-reviewArticle

Nanomedicine
Neoplasms
Pharmaceutical Preparations
Nanoparticles
Therapeutics
7 Citations

Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging

Srinivas, R., Satterlee, A., Wang, Y., Zhang, Y., Wang, Y. & Huang, L. Jan 1 2015 In : Nanoscale. 7, 44, p. 18542-18551 10 p.

Research output: Research - peer-reviewArticle

Indium
Nanoparticles
Imaging techniques
etoposide phosphate
Phosphates
10 Citations

Tri-peptide cationic lipids for gene delivery

Zhao, Y., Zhang, S., Zhang, Y., Cui, S., Chen, H., Zhi, D., Zhen, Y., Zhang, S. & Huang, L. Jan 7 2015 In : Journal of Materials Chemistry B. 3, 1, p. 119-126 8 p.

Research output: Research - peer-reviewArticle

Genes
Lipids
Peptides
DNA
Small Interfering RNA
25 Citations

Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy

Sha, H., Zou, Z., Xin, K., Bian, X., Cai, X., Lu, W., Chen, J., Chen, G., Huang, L., Blair, A. M., Cao, P. & Liu, B. Feb 28 2015 In : Journal of Controlled Release. 200, p. 188-200 13 p.

Research output: Research - peer-reviewArticle

Single-Domain Antibodies
Cellular Spheroids
Stomach Neoplasms
Peptides
Pharmaceutical Preparations
2014
63 Citations

Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation

Guo, S., Lin, C. M., Xu, Z., Miao, L., Wang, Y. & Huang, L. May 27 2014 In : ACS Nano. 8, 5, p. 4996-5009 14 p.

Research output: Research - peer-reviewArticle

therapy
delivery
tumors
modulation
acids
2 Citations

Composite Nanoparticles for Gene Delivery

Wang, Y. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 111-137 27 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Genes
Nanostructures
Inborn Genetic Diseases
Small Interfering RNA
34 Citations

Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles

Liu, Y., Hu, Y. & Huang, L. Mar 1 2014 In : Biomaterials. 35, 9, p. 3027-3034 8 p.

Research output: Research - peer-reviewArticle

Pharmacokinetics
Calcium phosphate
Lipids
Polyethylene glycols
Nanoparticles
30 Citations

Lipid-calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT/CT imaging of lymph node metastases

Tseng, Y. C., Xu, Z., Guley, K., Yuan, H. & Huang, L. Jan 1 2014 In : Biomaterials. 35, 16, p. 4688-4698 11 p.

Research output: Research - peer-reviewArticle

Lymphatic System
Nanoparticles
Lymph Nodes
Neoplasm Metastasis
Lipids
7 Citations

Lipid-Coated Calcium Phosphate Nanoparticles for Nonviral Gene Therapy

Haynes, M. T. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 205-229 25 p.

Research output: Research - peer-reviewArticle

Genetic Therapy
Nanoparticles
Lipids
calcium phosphate
Transfection
8 Citations

Lipid nanoparticles for gene delivery

Zhao, Y. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 13-36 24 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Lipids
Genes
Poisons
Genetic Therapy
68 Citations

Nanoparticle-delivered transforming growth factor-β siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment

Xu, Z., Wang, Y., Zhang, L. & Huang, L. Apr 22 2014 In : ACS Nano. 8, 4, p. 3636-3645 10 p.

Research output: Research - peer-reviewArticle

Transforming Growth Factor beta
Small Interfering RNA
Tumors
Nanoparticles
Intercellular Signaling Peptides and Proteins
12 Citations

Nonviral vectors. we have come a long way

Goodwin, T. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 1-12 12 p.

Research output: Research - peer-reviewArticle

Genetic Therapy
Growth
Clinical Trials
Medicine
Gene Expression
15 Citations

Novel Gemini cationic lipids with carbamate groups for gene delivery

Zhao, Y. N., Qureshi, F., Zhang, S. B., Cui, S. H., Wang, B., Chen, H. Y., Lv, H. T., Zhang, S. F. & Huang, L. May 21 2014 In : Journal of Materials Chemistry B. 2, 19, p. 2920-2928 9 p.

Research output: Research - peer-reviewArticle

Carbamates
Lipids
Genes
Liposomes
Transfection
42 Citations

Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model

Zhang, J., Miao, L., Guo, S., Zhang, Y., Zhang, L., Satterlee, A., Kim, W. Y. & Huang, L. May 28 2014 In : Journal of Controlled Release. 182, 1, p. 90-96 7 p.

Research output: Research - peer-reviewArticle

gemcitabine
Nanoparticles
Cisplatin
Urinary Bladder
Carcinoma
22 Citations

The cytochrome p450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease

Schuck, R. N., Zha, W., Edin, M. L., Gruzdev, A., Vendrov, K. C., Miller, T. M., Xu, Z., Lih, F. B., DeGraff, L. M., Tomer, K. B., Jones, H. M., Makowski, L., Huang, L., Poloyac, S. M., Zeldin, D. C. & Lee, C. R. Oct 13 2014 In : PLoS ONE. 9, 10, e110162

Research output: Research - peer-reviewArticle

fatty liver
liver diseases
cytochrome P-450
inflammation
liver
9 Citations

Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy

Guo, S., Wang, Y., Miao, L., Xu, Z., Lin, C. H. M. & Huang, L. Jan 1 2014 In : Biomaterials. 35, 26, p. 7647-7653 7 p.

Research output: Research - peer-reviewArticle

Cisplatin
Oils
Nanoparticles
Derivatives
Water
31 Citations

Unmodified drug used as a material to construct nanoparticles: Delivery of cisplatin for enhanced anti-cancer therapy

Guo, S., Miao, L., Wang, Y. & Huang, L. Jan 28 2014 In : Journal of Controlled Release. 174, 1, p. 137-142 6 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Cisplatin
Pharmaceutical Preparations
Neoplasms
Therapeutics
2013
51 Citations

A highly efficient synthetic vector: Nonhydrodynamic delivery of DNA to hepatocyte nuclei in vivo

Hu, Y., Haynes, M. T., Wang, Y., Liu, F. & Huang, L. Jun 25 2013 In : ACS Nano. 7, 6, p. 5376-5384 9 p.

Research output: Research - peer-reviewArticle

peptides
delivery
deoxyribonucleic acid
nuclei
Peptides
58 Citations

Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC

Zhang, Y., Schwerbrock, N. M. J., Rogers, A. B., Kim, W. Y. & Huang, L. Aug 1 2013 In : Molecular Therapy. 21, 8, p. 1559-1569 11 p.

Research output: Research - peer-reviewArticle

gemcitabine
Non-Small Cell Lung Carcinoma
Nanoparticles
Vascular Endothelial Growth Factor A
Small Interfering RNA
37 Citations

Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy

Zhang, Y., Peng, L., Mumper, R. J. & Huang, L. Nov 1 2013 In : Biomaterials. 34, 33, p. 8459-8468 10 p.

Research output: Research - peer-reviewArticle

Nucleosides
Small Interfering RNA
Tumors
Neoplasms
Therapeutics
18 Citations

How does the cell overcome LCP nanoparticle-induced calcium toxicity?

Tseng, Y. C., Yang, A. & Huang, L. Nov 4 2013 In : Molecular Pharmaceutics. 10, 11, p. 4391-4395 5 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Calcium
Necrosis
In Vitro Techniques
Poisons
20 Citations

Incorporation of histone derived recombinant protein for enhanced disassembly of core-membrane structured liposomal nanoparticles for efficient siRNA delivery

Wang, Y., Zhang, L., Guo, S., Hatefi, A. & Huang, L. Sep 17 2013 In : Journal of Controlled Release. 172, 1, p. 179-189 11 p.

Research output: Research - peer-reviewArticle

Protamines
Recombinant Proteins
Histones
Nanoparticles
Nucleic Acids
60 Citations

Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis

Wang, Y., Xu, Z., Guo, S., Zhang, L., Sharma, A., Robertson, G. P. & Huang, L. Oct 1 2013 In : Molecular Therapy. 21, 10, p. 1919-1929 11 p.

Research output: Research - peer-reviewArticle

Small Interfering RNA
Melanoma
Neoplasm Metastasis
Lung
Growth
56 Citations

Lipid-coated cisplatin nanoparticles induce neighboring effect and exhibit enhanced anticancer efficacy

Guo, S., Wang, Y., Miao, L., Xu, Z., Lin, C. M., Zhang, Y. & Huang, L. Nov 26 2013 In : ACS Nano. 7, 11, p. 9896-9904 9 p.

Research output: Research - peer-reviewArticle

Cisplatin
Nanoparticles
Lipids
lipids
nanoparticles
70 Citations

Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis

Xu, Z., Ramishetti, S., Tseng, Y. C., Guo, S., Wang, Y. & Huang, L. Sep 23 2013 In : Journal of Controlled Release. 172, 1, p. 259-265 7 p.

Research output: Research - peer-reviewArticle

Cytotoxic T-Lymphocytes
Nanoparticles
Melanoma
Neoplasm Metastasis
Lung
29 Citations

Nickel(II) dithiocarbamate complexes containing sulforhodamine B as fluorescent probes for selective detection of nitrogen dioxide

Yan, Y., Krishnakumar, S., Yu, H., Ramishetti, S., Deng, L. W., Wang, S., Huang, L. & Huang, D. Apr 10 2013 In : Journal of the American Chemical Society. 135, 14, p. 5312-5315 4 p.

Research output: Research - peer-reviewArticle

lissamine rhodamine B
Nitrogen Dioxide
Nickel
Fluorescent Dyes
Isomers
46 Citations

Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy

Zhang, Y., Kim, W. Y. & Huang, L. Apr 2013 In : Biomaterials. 34, 13, p. 3447-3458 12 p.

Research output: Research - peer-reviewArticle

Pancreatic Neoplasms
Non-Small Cell Lung Carcinoma
Nanoparticles
Lipids
Neoplasms
52 Citations

Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy

Wang, Y., Su, H. H., Yang, Y., Hu, Y., Zhang, L., Blancafort, P. & Huang, L. Feb 1 2013 In : Molecular Therapy. 21, 2, p. 358-367 10 p.

Research output: Research - peer-reviewArticle

Thymidine Kinase
Neoplasm Genes
Human Herpesvirus 1
Genetic Therapy
Messenger RNA