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1974 …2018
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Research Output 1974 2018

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Article
2018
6 Citations

BRAF peptide vaccine facilitates therapy of murine BRAF-mutant melanoma

Liu, Q., Zhu, H., Liu, Y., Musetti, S. & Huang, L., Feb 1 2018, In : Cancer Immunology, Immunotherapy. 67, 2, p. 299-310 12 p.

Research output: Contribution to journalArticle

Active Immunotherapy
Subunit Vaccines
Melanoma
Cytotoxic T-Lymphocytes
Immunosuppressive Agents
11 Citations

Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer

Liu, L., Wang, Y., Miao, L., Liu, Q., Musetti, S., Li, J. & Huang, L., Jan 3 2018, In : Molecular Therapy. 26, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Immunotherapy
Vaccines
Nanoparticles
Messenger RNA

Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers

Shen, L., Li, J., Liu, Q., Song, W., Zhang, X., Tiruthani, K., Hu, H., Das, M., Goodwin, T. J., Liu, R. & Huang, L., Jan 1 2018, (Accepted/In press) In : ACS Nano.

Research output: Contribution to journalArticle

interleukins
Chemokine CXCL12
Interleukin-10
Tumors
delivery
3 Citations

mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma

Wang, Y., Zhang, L., Xu, Z., Miao, L. & Huang, L., Feb 7 2018, In : Molecular Therapy. 26, 2, p. 420-434 15 p.

Research output: Contribution to journalArticle

Melanoma
Vaccines
Dendritic Cells
Antigens
Messenger RNA

Nano-delivery of fraxinellone remodels tumor microenvironment and facilitates therapeutic vaccination in desmoplastic melanoma

Hou, L., Liu, Q., Shen, L., Liu, Y., Zhang, X., Chen, F. & Huang, L., Jan 1 2018, In : Theranostics. 8, 14, p. 3781-3796 16 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Melanoma
Vaccination
Neoplasms
Therapeutics

Nanoparticle-mediated HMGA1 Silencing Promotes Lymphocyte Infiltration and Boosts Checkpoint Blockade Immunotherapy for Cancer

Wang, Y., Song, W., Hu, M., An, S., Xu, L., Li, J., Kinghorn, K. A., Liu, R. & Huang, L., Sep 5 2018, In : Advanced Functional Materials. 28, 36, 1802847.

Research output: Contribution to journalArticle

Patient treatment
High Mobility Group Proteins
Gene transfer
T-cells
Lymphocytes
3 Citations

Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma

Liu, Q., Zhu, H., Tiruthani, K., Shen, L., Chen, F., Gao, K., Zhang, X., Hou, L., Wang, D., Liu, R. & Huang, L., Feb 27 2018, In : ACS Nano. 12, 2, p. 1250-1261 12 p.

Research output: Contribution to journalArticle

Dermatology
Cytology
Cell signaling
Oncology
T-cells
3 Citations

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

Song, W., Shen, L., Wang, Y., Liu, Q., Goodwin, T. J., Li, J., Dorosheva, O., Liu, T., Liu, R. & Huang, L., Dec 1 2018, In : Nature communications. 9, 1, 2237.

Research output: Contribution to journalArticle

oxaliplatin
Chemotherapy
chemotherapy
Immunotherapy
cancer

Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis

Song, W., Tiruthani, K., Wang, Y., Shen, L., Hu, M., Dorosheva, O., Qiu, K., Kinghorn, K. A., Liu, R. & Huang, L., Jan 1 2018, (Accepted/In press) In : Advanced Materials. 1805007.

Research output: Contribution to journalArticle

T-cells
Pathology
Drug delivery
Nanotechnology
Liver
2017

A dosimetric model for the heterogeneous delivery of radioactive nanoparticles In vivo: A feasibility study

Satterlee, A. B., Attayek, P., Midkiff, B. & Huang, L., Mar 17 2017, In : Radiation Oncology. 12, 1, 54.

Research output: Contribution to journalArticle

Feasibility Studies
Nanoparticles
Neoplasms
Anatomy
Radiotherapy
4 Citations

Dual Functional LipoMET Mediates Envelope-type Nanoparticles to Combinational Oncogene Silencing and Tumor Growth Inhibition

Shi, K., Zhao, Y., Miao, L., Satterlee, A., Haynes, M., Luo, C., Musetti, S. & Huang, L., Jul 5 2017, In : Molecular Therapy. 25, 7, p. 1567-1579 13 p.

Research output: Contribution to journalArticle

Oncogenes
Nanoparticles
Small Interfering RNA
Vascular Endothelial Growth Factor A
Growth
11 Citations

Enhancing nanoparticle accumulation and retention in desmoplastic tumors via vascular disruption for internal radiation therapy

Satterlee, A. B., Rojas, J. D., Dayton, P. A. & Huang, L., Jan 1 2017, In : Theranostics. 7, 2, p. 253-269 17 p.

Research output: Contribution to journalArticle

Nanoparticles
Blood Vessels
Radiotherapy
Neoplasms
Phosphates
15 Citations

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

Cheng, L., Wang, Y. & Huang, L., Jul 5 2017, In : Molecular Therapy. 25, 7, p. 1665-1675 11 p.

Research output: Contribution to journalArticle

Exosomes
Cancer Vaccines
Lymph Nodes
Macrophages
Immunologic Adjuvants
8 Citations

Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis

Goodwin, T. J. & Huang, L., May 2 2017, In : Vaccine. 35, 19, p. 2550-2557 8 p.

Research output: Contribution to journalArticle

Liver Neoplasms
colorectal neoplasms
metastasis
adjuvants
Colorectal Neoplasms
5 Citations

Liver specific gene immunotherapies resolve immune suppressive ectopic lymphoid structures of liver metastases and prolong survival

Goodwin, T. J., Shen, L., Hu, M., Li, J., Feng, R., Dorosheva, O., Liu, R. & Huang, L., Oct 1 2017, In : Biomaterials. 141, p. 260-271 12 p.

Research output: Contribution to journalArticle

Liver
Immunotherapy
Genes
Neoplasm Metastasis
Survival
22 Citations

Quercetin Remodels the Tumor Microenvironment to Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles

Hu, K., Miao, L., Goodwin, T. J., Li, J., Liu, Q. & Huang, L., May 23 2017, In : ACS Nano. 11, 5, p. 4916-4925 10 p.

Research output: Contribution to journalArticle

Quercetin
Permeation
Tumors
tumors
Nanoparticles
24 Citations

Targeting tumor-associated fibroblasts for therapeutic delivery in desmoplastic tumors

Miao, L., Liu, Q., Lin, C. M., Luo, C., Wang, Y., Liu, L., Yin, W., Hu, S., Kim, W. Y. & Huang, L., Feb 1 2017, In : Cancer Research. 77, 3, p. 719-731 13 p.

Research output: Contribution to journalArticle

Nanoparticles
Neoplasms
Heterografts
Fibroblasts
Therapeutics
12 Citations

Transient and Local Expression of Chemokine and Immune Checkpoint Traps to Treat Pancreatic Cancer

Miao, L., Li, J., Liu, Q., Feng, R., Das, M., Lin, C. M., Goodwin, T. J., Dorosheva, O., Liu, R. & Huang, L., Sep 26 2017, In : ACS Nano. 11, 9, p. 8690-8706 17 p.

Research output: Contribution to journalArticle

Chemokines
Tumors
tumors
cancer
traps
22 Citations

Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment

Huo, M., Zhao, Y., Satterlee, A. B., Wang, Y., Xu, Y. & Huang, L., Jan 10 2017, In : Journal of Controlled Release. 245, p. 81-94 14 p.

Research output: Contribution to journalArticle

Active Immunotherapy
Tumor Microenvironment
Melanoma
Neoplasms
Vascular Tissue Neoplasms
2016
14 Citations

A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA

Luo, C., Miao, L., Zhao, Y., Musetti, S., Wang, Y., Shi, K. & Huang, L., Sep 1 2016, In : Biomaterials. 102, p. 239-248 10 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Gene therapy
Propane
Biguanides
Cell death
15 Citations

Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer

Xiong, Y., Zhao, Y., Miao, L., Lin, C. M. & Huang, L., Dec 28 2016, In : Journal of Controlled Release. 244, p. 63-73 11 p.

Research output: Contribution to journalArticle

Metformin
Non-Small Cell Lung Carcinoma
Nanoparticles
Cisplatin
Membranes
27 Citations

Curcumin micelles remodel tumor microenvironment and enhance vaccine activity in an advanced melanoma model

Lu, Y., Miao, L., Wang, Y., Xu, Z., Zhao, Y., Shen, Y., Xiang, G. & Huang, L., Feb 1 2016, In : Molecular Therapy. 24, 2, p. 364-374 11 p.

Research output: Contribution to journalArticle

Curcumin
Tumor Microenvironment
Micelles
Melanoma
Vaccines
9 Citations

Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approach

Lu, Y., Wang, Y., Miao, L., Haynes, M., Xiang, G. & Huang, L., Aug 28 2016, In : Cancer Letters. 379, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

Nanomedicine
Melanoma
Antigens
Drug Therapy
Neoplasms
15 Citations

Local and transient gene expression primes the liver to resist cancer metastasis

Goodwin, T. J., Zhou, Y., Musetti, S. N., Liu, R. & Huang, L., Nov 9 2016, In : Science Translational Medicine. 8, 364, 364ra153.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Gene Expression
Liver
Neoplasms
Immunosuppressive Agents
6 Citations
Liposomes
Phospholipids
Calcium phosphate
Chain length
Lipids
24 Citations

Nanoparticle delivered VEGF-A siRNA enhances photodynamic therapy for head and neck cancer treatment

Lecaros, R. L. G., Huang, L., Lee, T. C. & Hsu, Y. C., Feb 1 2016, In : Molecular Therapy. 24, 1, p. 106-116 11 p.

Research output: Contribution to journalArticle

Photochemotherapy
Head and Neck Neoplasms
Nanoparticles
Vascular Endothelial Growth Factor A
Small Interfering RNA
26 Citations

PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

Zhao, Y., Wang, W., Guo, S., Wang, Y., Miao, L., Xiong, Y. & Huang, L., Jun 6 2016, In : Nature Communications. 7, 11822.

Research output: Contribution to journalArticle

Metformin
Small Interfering RNA
lipids
delivery
Hyaluronic Acid
61 Citations

Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

Luo, C., Sun, J., Liu, D., Sun, B., Miao, L., Musetti, S., Li, J., Han, X., Du, Y., Li, L., Huang, L. & He, Z., Sep 14 2016, In : Nano Letters. 16, 9, p. 5401-5408 8 p.

Research output: Contribution to journalArticle

Nanosystems
Chemotherapy
Oleic acid
Prodrugs
Sulfides
17 Citations

Sigma receptor-mediated targeted delivery of anti-angiogenic multifunctional nanodrugs for combination tumor therapy

Li, Y., Wu, Y., Huang, L., Miao, L., Zhou, J., Satterlee, A. B. & Yao, J., Apr 28 2016, In : Journal of Controlled Release. 228, p. 107-119 13 p.

Research output: Contribution to journalArticle

sigma Receptors
Low Molecular Weight Heparin
Neoplasms
Anticoagulants
Therapeutics
29 Citations

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

Miao, L., Newby, J. M., Lin, C. M., Zhang, L., Xu, F., Kim, W. Y., Forest, M. G., Lai, S. K., Milowsky, M. I., Wobker, S. E. & Huang, L., Oct 25 2016, In : ACS Nano. 10, 10, p. 9243-9258 16 p.

Research output: Contribution to journalArticle

fibroblasts
Binding sites
Fibroblasts
vessels
Tumors
2015
18 Citations

A radio-theranostic nanoparticle with high specific drug loading for cancer therapy and imaging

Satterlee, A. B., Yuan, H. & Huang, L., Nov 10 2015, In : Journal of Controlled Release. 217, p. 170-182 13 p.

Research output: Contribution to journalArticle

Radio
Nanoparticles
Lipids
Radioisotopes
Pharmaceutical Preparations
33 Citations

Exploring the tumor microenvironment with nanoparticles

Miao, L. & Huang, L., Jan 1 2015, In : Cancer treatment and research. 166, p. 193-226 34 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Nanoparticles
Neoplasms
Nanotechnology
Therapeutic Uses
24 Citations

Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma

Zhao, Y., Huo, M., Xu, Z., Wang, Y. & Huang, L., Nov 1 2015, In : Biomaterials. 68, p. 54-66 13 p.

Research output: Contribution to journalArticle

Active Immunotherapy
Tumor Microenvironment
Vaccines
Nanoparticles
Tumors
37 Citations

Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment strategy for head-and-neck cancer

Chen, W. H., Lecaros, R. L. G., Tseng, Y. C., Huang, L. & Hsu, Y. C., Jan 1 2015, In : Cancer Letters. 359, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

Photochemotherapy
Head and Neck Neoplasms
Nanoparticles
Small Interfering RNA
Neoplasms
30 Citations

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

Miao, L., Wang, Y., Lin, C. M., Xiong, Y., Chen, N., Zhang, L., Kim, W. Y. & Huang, L., Nov 10 2015, In : Journal of Controlled Release. 217, p. 27-41 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Nanoparticles
Cisplatin
Therapeutics
Phenotype
21 Citations

Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells

Tang, J., Li, L., Howard, C. B., Mahler, S. M., Huang, L. & Xu, Z. P., Jul 29 2015, In : Journal of Materials Chemistry B. 3, 33, p. 6805-6812 8 p.

Research output: Contribution to journalArticle

Calcium phosphate
Lipids
Small Interfering RNA
Genes
Cells
45 Citations

Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors

Miao, L., Lin, C. M. & Huang, L., Dec 10 2015, In : Journal of Controlled Release. 219, p. 192-204 13 p.

Research output: Contribution to journalArticle

Nanomedicine
Nanoparticles
Neoplasms
Pharmaceutical Preparations
Extracellular Matrix
9 Citations

Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging

Srinivas, R., Satterlee, A., Wang, Y., Zhang, Y., Wang, Y. & Huang, L., Jan 1 2015, In : Nanoscale. 7, 44, p. 18542-18551 10 p.

Research output: Contribution to journalArticle

Indium
Phosphates
Nanoparticles
Imaging techniques
Cells
16 Citations

Tri-peptide cationic lipids for gene delivery

Zhao, Y., Zhang, S., Zhang, Y., Cui, S., Chen, H., Zhi, D., Zhen, Y., Zhang, S. & Huang, L., Jan 7 2015, In : Journal of Materials Chemistry B. 3, 1, p. 119-126 8 p.

Research output: Contribution to journalArticle

Lipids
Peptides
Genes
DNA
Small Interfering RNA
41 Citations

Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy

Sha, H., Zou, Z., Xin, K., Bian, X., Cai, X., Lu, W., Chen, J., Chen, G., Huang, L., Blair, A. M., Cao, P. & Liu, B., Feb 28 2015, In : Journal of Controlled Release. 200, p. 188-200 13 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Cellular Spheroids
Stomach Neoplasms
Peptides
Pharmaceutical Preparations
2014
80 Citations

Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation

Guo, S., Lin, C. M., Xu, Z., Miao, L., Wang, Y. & Huang, L., May 27 2014, In : ACS Nano. 8, 5, p. 4996-5009 14 p.

Research output: Contribution to journalArticle

Sirolimus
Cisplatin
Tumors
therapy
delivery
6 Citations

Composite Nanoparticles for Gene Delivery

Wang, Y. & Huang, L., Jan 1 2014, In : Advances in Genetics. 88, p. 111-137 27 p.

Research output: Contribution to journalArticle

Nanoparticles
Genes
Nanostructures
Inborn Genetic Diseases
Small Interfering RNA
46 Citations

Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles

Liu, Y., Hu, Y. & Huang, L., Mar 1 2014, In : Biomaterials. 35, 9, p. 3027-3034 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Calcium phosphate
Nanoparticles
Lipids
Polyethylene glycols
42 Citations

Lipid-calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT/CT imaging of lymph node metastases

Tseng, Y. C., Xu, Z., Guley, K., Yuan, H. & Huang, L., Jan 1 2014, In : Biomaterials. 35, 16, p. 4688-4698 11 p.

Research output: Contribution to journalArticle

Lymphatic System
Calcium phosphate
Nanoparticles
Lipids
Lymph Nodes
9 Citations

Lipid-Coated Calcium Phosphate Nanoparticles for Nonviral Gene Therapy

Haynes, M. T. & Huang, L., Jan 1 2014, In : Advances in Genetics. 88, p. 205-229 25 p.

Research output: Contribution to journalArticle

Genetic Therapy
Nanoparticles
Lipids
Transfection
Nanotechnology
20 Citations

Lipid nanoparticles for gene delivery

Zhao, Y. & Huang, L., Jan 1 2014, In : Advances in Genetics. 88, p. 13-36 24 p.

Research output: Contribution to journalArticle

Nanoparticles
Lipids
Poisons
Genetic Therapy
Genes
90 Citations

Nanoparticle-delivered transforming growth factor-β siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment

Xu, Z., Wang, Y., Zhang, L. & Huang, L., Apr 22 2014, In : ACS Nano. 8, 4, p. 3636-3645 10 p.

Research output: Contribution to journalArticle

beta factor
Transforming Growth Factor beta
Small Interfering RNA
Tumors
tumors
62 Citations

Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer

Miao, L., Guo, S., Zhang, J., Kim, W. Y. & Huang, L., Nov 1 2014, In : Advanced Functional Materials. 24, 42, p. 6601-6611 11 p.

Research output: Contribution to journalArticle

gemcitabine
bladder
Cisplatin
Tumors
delivery
16 Citations

Nonviral vectors. we have come a long way

Goodwin, T. & Huang, L., Jan 1 2014, In : Advances in Genetics. 88, p. 1-12 12 p.

Research output: Contribution to journalArticle

Genetic Therapy
Growth
Clinical Trials
Medicine
Gene Expression
20 Citations

Novel Gemini cationic lipids with carbamate groups for gene delivery

Zhao, Y. N., Qureshi, F., Zhang, S. B., Cui, S. H., Wang, B., Chen, H. Y., Lv, H. T., Zhang, S. F. & Huang, L., May 21 2014, In : Journal of Materials Chemistry B. 2, 19, p. 2920-2928 9 p.

Research output: Contribution to journalArticle

Carbamates
Lipids
Liposomes
Genes
Hydrocarbons