Research Output 1974 2017

2017

A dosimetric model for the heterogeneous delivery of radioactive nanoparticles In vivo: A feasibility study

Satterlee, A. B., Attayek, P., Midkiff, B. & Huang, L. Mar 17 2017 In : Radiation Oncology. 12, 1, 54

Research output: Research - peer-reviewArticle

Feasibility Studies
Nanoparticles
Neoplasms
Anatomy
Radiotherapy
6 Citations

Enhancing nanoparticle accumulation and retention in desmoplastic tumors via vascular disruption for internal radiation therapy

Satterlee, A. B., Rojas, J. D., Dayton, P. A. & Huang, L. 2017 In : Theranostics. 7, 2, p. 253-269 17 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Blood Vessels
Radiotherapy
Neoplasms
Therapeutics
3 Citations
Liver Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Antigens
Peptides
9 Citations

Targeting tumor-associated fibroblasts for therapeutic delivery in desmoplastic tumors

Miao, L., Liu, Q., Lin, C. M., Luo, C., Wang, Y., Liu, L., Yin, W., Hu, S., Kim, W. Y. & Huang, L. Feb 1 2017 In : Cancer Research. 77, 3, p. 719-731 13 p.

Research output: Research - peer-reviewArticle

Neoplasms
Therapeutics
Cancer-Associated Fibroblasts
Nanoparticles
Heterografts
5 Citations

Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment

Huo, M., Zhao, Y., Satterlee, A. B., Wang, Y., Xu, Y. & Huang, L. Jan 10 2017 In : Journal of Controlled Release. 245, p. 81-94 14 p.

Research output: Research - peer-reviewArticle

Active Immunotherapy
Tumor Microenvironment
Melanoma
Neoplasms
sunitinib
2016
8 Citations

A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA

Luo, C., Miao, L., Zhao, Y., Musetti, S., Wang, Y., Shi, K. & Huang, L. Sep 1 2016 In : Biomaterials. 102, p. 239-248 10 p.

Research output: Research - peer-reviewArticle

TNF-Related Apoptosis-Inducing Ligand
Propane
Genetic Therapy
Lipids
DNA
9 Citations

Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer

Xiong, Y., Zhao, Y., Miao, L., Lin, C. M. & Huang, L. Dec 28 2016 In : Journal of Controlled Release. 244, p. 63-73 11 p.

Research output: Research - peer-reviewArticle

Metformin
Non-Small Cell Lung Carcinoma
Nanoparticles
Cisplatin
Membranes
15 Citations

Curcumin micelles remodel tumor microenvironment and enhance vaccine activity in an advanced melanoma model

Lu, Y., Miao, L., Wang, Y., Xu, Z., Zhao, Y., Shen, Y., Xiang, G. & Huang, L. Feb 1 2016 In : Molecular Therapy. 24, 2, p. 364-374 11 p.

Research output: Research - peer-reviewArticle

Curcumin
Tumor Microenvironment
Micelles
Melanoma
Vaccines
8 Citations

Current and future theranostic applications of the lipid-calcium-phosphate nanoparticle platform

Satterlee, A. B. & Huang, L. 2016 In : Theranostics. 6, 7, p. 918-929 12 p.

Research output: Research - peer-reviewReview article

Nanoparticles
Lipids
Theranostic Nanomedicine
calcium phosphate
Cytotoxins
5 Citations

Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approach

Lu, Y., Wang, Y., Miao, L., Haynes, M., Xiang, G. & Huang, L. Aug 28 2016 In : Cancer Letters. 379, 1, p. 32-38 7 p.

Research output: Research - peer-reviewArticle

Nanomedicine
Melanoma
Antigens
Drug Therapy
Neoplasms
5 Citations

Local and transient gene expression primes the liver to resist cancer metastasis

Goodwin, T. J., Zhou, Y., Musetti, S. N., Liu, R. & Huang, L. Nov 9 2016 In : Science Translational Medicine. 8, 364, 364ra153

Research output: Research - peer-reviewArticle

Neoplasm Metastasis
Gene Expression
Liver
Neoplasms
Breast Neoplasms
1 Citations
Liposomes
Phospholipids
Calcium phosphate
Chain length
Lipids
4 Citations

Multistage delivery technologies: Multifunctional, interdisciplinary approaches to nanomedicine

Haynes, M. T. & Huang, L. May 1 2016 In : Molecular Therapy. 24, 5, p. 849-851 3 p.

Research output: Research - peer-reviewComment/debate

15 Citations

Nanoparticle delivered VEGF-A siRNA enhances photodynamic therapy for head and neck cancer treatment

Lecaros, R. L. G., Huang, L., Lee, T. C. & Hsu, Y. C. Feb 1 2016 In : Molecular Therapy. 24, 1, p. 106-116 11 p.

Research output: Research - peer-reviewArticle

Photochemotherapy
Head and Neck Neoplasms
Nanoparticles
Vascular Endothelial Growth Factor A
Small Interfering RNA

Pieter Cullis: an outstanding lipid biophysicist, drug delivery scientist, educator, and entrepreneur

Huang, L. & Miao, L. Oct 20 2016 In : Journal of Drug Targeting. 24, 9, p. 762-764 3 p.

Research output: Research - peer-reviewComment/debate

Mentors
Membrane Fusion
Nanoparticles
Lipids
Pharmaceutical Preparations
11 Citations

PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

Zhao, Y., Wang, W., Guo, S., Wang, Y., Miao, L., Xiong, Y. & Huang, L. Jun 6 2016 In : Nature Communications. 7, 11822

Research output: Research - peer-reviewArticle

Metformin
Small Interfering RNA
lipids
delivery
nanoparticles
22 Citations

Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

Luo, C., Sun, J., Liu, D., Sun, B., Miao, L., Musetti, S., Li, J., Han, X., Du, Y., Li, L., Huang, L. & He, Z. Sep 14 2016 In : Nano Letters. 16, 9, p. 5401-5408 8 p.

Research output: Research - peer-reviewArticle

Nanosystems
Chemotherapy
Prodrugs
Sulfides
Paclitaxel
8 Citations

Sigma receptor-mediated targeted delivery of anti-angiogenic multifunctional nanodrugs for combination tumor therapy

Li, Y., Wu, Y., Huang, L., Miao, L., Zhou, J., Satterlee, A. B. & Yao, J. Apr 28 2016 In : Journal of Controlled Release. 228, p. 107-119 13 p.

Research output: Research - peer-reviewArticle

sigma Receptors
Low Molecular Weight Heparin
Neoplasms
Therapeutics
Anticoagulants
15 Citations

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

Miao, L., Newby, J. M., Lin, C. M., Zhang, L., Xu, F., Kim, W. Y., Forest, M. G., Lai, S. K., Milowsky, M. I., Wobker, S. E. & Huang, L. Oct 25 2016 In : ACS Nano. 10, 10, p. 9243-9258 16 p.

Research output: Research - peer-reviewArticle

fibroblasts
vessels
tumors
nanoparticles
Fibroblasts
2015
10 Citations

A radio-theranostic nanoparticle with high specific drug loading for cancer therapy and imaging

Satterlee, A. B., Yuan, H. & Huang, L. Nov 10 2015 In : Journal of Controlled Release. 217, p. 170-182 13 p.

Research output: Research - peer-reviewArticle

Radio
Nanoparticles
Lipids
Pharmaceutical Preparations
Neoplasms
36 Citations

Delivery of oligonucleotides with lipid nanoparticles

Wang, Y., Miao, L., Satterlee, A. & Huang, L. Jan 1 2015 In : Advanced Drug Delivery Reviews. 87, p. 68-80 13 p.

Research output: Research - peer-reviewReview article

Oligonucleotides
Nanoparticles
Lipids
Therapeutics
Drug Delivery Systems
23 Citations

Exploring the tumor microenvironment with nanoparticles

Miao, L. & Huang, L. 2015 In : Cancer Treatment and Research. 166, p. 193-226 34 p.

Research output: Research - peer-reviewArticle

Tumor Microenvironment
Nanoparticles
Neoplasms
Nanotechnology
Therapeutic Uses
104 Citations

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

Chen, Y., Gao, D. Y. & Huang, L. Jan 1 2015 In : Advanced Drug Delivery Reviews. 81, p. 128-141 14 p.

Research output: Research - peer-reviewReview article

MicroRNAs
Neoplasms
Therapeutics
Gene Expression
Small Untranslated RNA
19 Citations

Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma

Zhao, Y., Huo, M., Xu, Z., Wang, Y. & Huang, L. Nov 1 2015 In : Biomaterials. 68, p. 54-66 13 p.

Research output: Research - peer-reviewArticle

Active Immunotherapy
Tumor Microenvironment
Nanoparticles
Melanoma
methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
30 Citations

Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment strategy for head-and-neck cancer

Chen, W. H., Lecaros, R. L. G., Tseng, Y. C., Huang, L. & Hsu, Y. C. Jan 1 2015 In : Cancer Letters. 359, 1, p. 65-74 10 p.

Research output: Research - peer-reviewArticle

Photochemotherapy
Head and Neck Neoplasms
Nanoparticles
Small Interfering RNA
Therapeutics
22 Citations

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

Miao, L., Wang, Y., Lin, C. M., Xiong, Y., Chen, N., Zhang, L., Kim, W. Y. & Huang, L. Nov 10 2015 In : Journal of Controlled Release. 217, p. 27-41 15 p.

Research output: Research - peer-reviewArticle

Tumor Microenvironment
Nanoparticles
Cisplatin
Therapeutics
Cancer-Associated Fibroblasts
10 Citations

Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells

Tang, J., Li, L., Howard, C. B., Mahler, S. M., Huang, L. & Xu, Z. P. Jul 29 2015 In : Journal of Materials Chemistry B. 3, 33, p. 6805-6812 8 p.

Research output: Research - peer-reviewArticle

Small Interfering RNA
Genes
Cells
Nanoparticles
Lipids
32 Citations

Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors

Miao, L., Lin, C. M. & Huang, L. Dec 10 2015 In : Journal of Controlled Release. 219, p. 192-204 13 p.

Research output: Research - peer-reviewArticle

Nanomedicine
Neoplasms
Pharmaceutical Preparations
Nanoparticles
Therapeutics
7 Citations

Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging

Srinivas, R., Satterlee, A., Wang, Y., Zhang, Y., Wang, Y. & Huang, L. Jan 1 2015 In : Nanoscale. 7, 44, p. 18542-18551 10 p.

Research output: Research - peer-reviewArticle

Indium
Nanoparticles
Imaging techniques
etoposide phosphate
Phosphates
10 Citations

Tri-peptide cationic lipids for gene delivery

Zhao, Y., Zhang, S., Zhang, Y., Cui, S., Chen, H., Zhi, D., Zhen, Y., Zhang, S. & Huang, L. Jan 7 2015 In : Journal of Materials Chemistry B. 3, 1, p. 119-126 8 p.

Research output: Research - peer-reviewArticle

Genes
Lipids
Peptides
DNA
Small Interfering RNA
25 Citations

Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy

Sha, H., Zou, Z., Xin, K., Bian, X., Cai, X., Lu, W., Chen, J., Chen, G., Huang, L., Blair, A. M., Cao, P. & Liu, B. Feb 28 2015 In : Journal of Controlled Release. 200, p. 188-200 13 p.

Research output: Research - peer-reviewArticle

Single-Domain Antibodies
Cellular Spheroids
Stomach Neoplasms
Peptides
Pharmaceutical Preparations
2014
1 Citations

Cancer Therapy with RNAi Delivered by Non-viral Membrane/Core Nanoparticles

Satterlee, A. B. & Huang, L. Mar 17 2014 Cancer Gene Therapy by Viral and Non-viral Vectors. Wiley Blackwell, p. 61-78 18 p.

Research output: ResearchChapter

RNA Interference
Nanoparticles
Membranes
Neoplasms
Therapeutics
63 Citations

Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation

Guo, S., Lin, C. M., Xu, Z., Miao, L., Wang, Y. & Huang, L. May 27 2014 In : ACS Nano. 8, 5, p. 4996-5009 14 p.

Research output: Research - peer-reviewArticle

therapy
delivery
tumors
modulation
acids
2 Citations

Composite Nanoparticles for Gene Delivery

Wang, Y. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 111-137 27 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Genes
Nanostructures
Inborn Genetic Diseases
Small Interfering RNA
7 Citations

Hepatic RNA interference: Delivery by synthetic vectors

Haynes, M. T. & Huang, L. Feb 2014 In : Drug Delivery and Translational Research. 4, 1, p. 61-73 13 p.

Research output: Research - peer-reviewReview article

RNA Interference
Liver
Therapeutics
RNA
Technology
34 Citations

Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles

Liu, Y., Hu, Y. & Huang, L. Mar 1 2014 In : Biomaterials. 35, 9, p. 3027-3034 8 p.

Research output: Research - peer-reviewArticle

Pharmacokinetics
Calcium phosphate
Lipids
Polyethylene glycols
Nanoparticles
1 Citations

In vitro therapeutic effect of PDT combined with VEGF-A gene therapy

Lecaros, R. L. G., Huang, L. & Hsu, Y. C. 2014 Biophotonics and Immune Responses IX. SPIE, Vol. 8944, 894405

Research output: ResearchConference contribution

Photochemotherapy
Therapeutic Uses
Genetic Therapy
Vascular Endothelial Growth Factor A
Neoplasms
30 Citations

Lipid-calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT/CT imaging of lymph node metastases

Tseng, Y. C., Xu, Z., Guley, K., Yuan, H. & Huang, L. Jan 1 2014 In : Biomaterials. 35, 16, p. 4688-4698 11 p.

Research output: Research - peer-reviewArticle

Lymphatic System
Nanoparticles
Lymph Nodes
Neoplasm Metastasis
Lipids
7 Citations

Lipid-Coated Calcium Phosphate Nanoparticles for Nonviral Gene Therapy

Haynes, M. T. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 205-229 25 p.

Research output: Research - peer-reviewArticle

Genetic Therapy
Nanoparticles
Lipids
calcium phosphate
Transfection
8 Citations

Lipid nanoparticles for gene delivery

Zhao, Y. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 13-36 24 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Lipids
Genes
Poisons
Genetic Therapy
68 Citations

Nanoparticle-delivered transforming growth factor-β siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment

Xu, Z., Wang, Y., Zhang, L. & Huang, L. Apr 22 2014 In : ACS Nano. 8, 4, p. 3636-3645 10 p.

Research output: Research - peer-reviewArticle

Transforming Growth Factor beta
Small Interfering RNA
Tumors
Nanoparticles
Intercellular Signaling Peptides and Proteins
45 Citations

Nanoparticles containing insoluble drug for cancer therapy

Guo, S. & Huang, L. Jan 1 2014 In : Biotechnology Advances. 32, 4, p. 778-788 11 p.

Research output: Research - peer-reviewReview article

Nanoparticles
Drug Therapy
Neoplasms
Pharmaceutical Preparations
Drug Compounding
32 Citations

Non-viral nanocarriers for siRNA delivery in breast cancer

Zhang, J., Li, X. & Huang, L. Sep 28 2014 In : Journal of Controlled Release. 190, p. 440-450 11 p.

Research output: Research - peer-reviewReview article

Small Interfering RNA
Breast Neoplasms
Gene Silencing
Carcinogenesis
Therapeutics
12 Citations

Nonviral vectors. we have come a long way

Goodwin, T. & Huang, L. Jan 1 2014 In : Advances in Genetics. 88, p. 1-12 12 p.

Research output: Research - peer-reviewArticle

Genetic Therapy
Growth
Clinical Trials
Medicine
Gene Expression
15 Citations

Novel Gemini cationic lipids with carbamate groups for gene delivery

Zhao, Y. N., Qureshi, F., Zhang, S. B., Cui, S. H., Wang, B., Chen, H. Y., Lv, H. T., Zhang, S. F. & Huang, L. May 21 2014 In : Journal of Materials Chemistry B. 2, 19, p. 2920-2928 9 p.

Research output: Research - peer-reviewArticle

Carbamates
Lipids
Genes
Liposomes
Transfection
42 Citations

Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model

Zhang, J., Miao, L., Guo, S., Zhang, Y., Zhang, L., Satterlee, A., Kim, W. Y. & Huang, L. May 28 2014 In : Journal of Controlled Release. 182, 1, p. 90-96 7 p.

Research output: Research - peer-reviewArticle

gemcitabine
Nanoparticles
Cisplatin
Urinary Bladder
Carcinoma
22 Citations

The cytochrome p450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease

Schuck, R. N., Zha, W., Edin, M. L., Gruzdev, A., Vendrov, K. C., Miller, T. M., Xu, Z., Lih, F. B., DeGraff, L. M., Tomer, K. B., Jones, H. M., Makowski, L., Huang, L., Poloyac, S. M., Zeldin, D. C. & Lee, C. R. Oct 13 2014 In : PLoS ONE. 9, 10, e110162

Research output: Research - peer-reviewArticle

fatty liver
liver diseases
cytochrome P-450
inflammation
liver
9 Citations

Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy

Guo, S., Wang, Y., Miao, L., Xu, Z., Lin, C. H. M. & Huang, L. Jan 1 2014 In : Biomaterials. 35, 26, p. 7647-7653 7 p.

Research output: Research - peer-reviewArticle

Cisplatin
Oils
Nanoparticles
Derivatives
Water
31 Citations

Unmodified drug used as a material to construct nanoparticles: Delivery of cisplatin for enhanced anti-cancer therapy

Guo, S., Miao, L., Wang, Y. & Huang, L. Jan 28 2014 In : Journal of Controlled Release. 174, 1, p. 137-142 6 p.

Research output: Research - peer-reviewArticle

Nanoparticles
Cisplatin
Pharmaceutical Preparations
Neoplasms
Therapeutics