Research Output 1965 2018

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2018

Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives

Chen, Z., Duan, H., Tong, X., Hsu, P., Han, L., Morris-Natschke, S. L., Yang, S., Liu, W. & Lee, K. H. Mar 23 2018 In : Journal of Natural Products. 81, 3, p. 465-474 10 p.

Research output: Contribution to journalArticle

Apoptosis
Lung Neoplasms
Gasohol
Structure-Activity Relationship
Antineoplastic Agents

Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities

Ling, Y., Yang, Q. X., Teng, Y. N., Chen, S., Gao, W. J., Guo, J., Hsu, P. L., Liu, Y., Morris-Natschke, S. L., Hung, C. C. & Lee, K. H. Jun 25 2018 In : European Journal of Medicinal Chemistry. 154, p. 199-209 11 p.

Research output: Contribution to journalArticle

Slip forming
KB Cells
NAD
Oxidoreductases
Pharmaceutical Preparations

Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study

Chang, L. C., Hsieh, M. T., Yang, J. S., Lu, C. C., Tsai, F. J., Tsao, J. W., Chiu, Y. J., Kuo, S. C. & Lee, K. H. Jan 1 2018 In : International journal of oncology. 52, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Autophagy
Cell Cycle Checkpoints
Adenocarcinoma
Breast
Apoptosis

Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor

Huang, L., Lai, W. H., Zhu, L., Li, W., Wei, L., Lee, K. H., Xie, L. & Chen, C. H. Mar 8 2018 In : ACS Medicinal Chemistry Letters. 9, 3, p. 268-273 6 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
HIV-1
Trickling filtration
Blood Cells
gnidimacrin

Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi

Hu, X. F., Zhang, Q., Zhang, P. P., Sun, L. J., Liang, J. C., Morris-Natschke, S. L., Chen, Y. & Lee, K. H. Jun 1 2018 In : Fitoterapia. 127, p. 129-137 9 p.

Research output: Contribution to journalArticle

Physalis
Cytochrome P-450 CYP2E1
Insulin Resistance
Antioxidants
Flavonoids

Four new C19-diterpenoid alkaloids from Delphinium elatum

Yamashita, H., Katoh, M., Kokubun, A., Uchimura, A., Mikami, S., Takeuchi, A., Kaneda, K., Suzuki, Y., Mizukami, M., Goto, M., Lee, K. H. & Wada, K. Apr 1 2018 In : Phytochemistry Letters. 24, p. 6-9 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
Computer operating procedures
diterpenoid alkaloids
Applicators

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

Yamashita, H., Takeda, K., Haraguchi, M., Abe, Y., Kuwahara, N., Suzuki, S., Terui, A., Masaka, T., Munakata, N., Uchida, M., Nunokawa, M., Kaneda, K., Goto, M., Lee, K. H. & Wada, K. Jan 1 2018 In : Journal of Natural Medicines. 72, 1, p. 230-237 8 p.

Research output: Contribution to journalArticle

Aconitum
Computer operating procedures
Applicators
Diterpenes
Alkaloids

Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris

Teng, Y. N., Wang, Y., Hsu, P. L., Xin, G., Zhang, Y., Morris-Natschke, S. L., Goto, M. & Lee, K. H. Mar 1 2018 In : Phytomedicine. 41, p. 62-66 5 p.

Research output: Contribution to journalArticle

Euphorbia
Multiple Drug Resistance
Diterpenes
Seeds
lissamine rhodamine B

SAR study on: N 2, N 4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents

Jing, L., Tang, Y., Goto, M., Lee, K. H. & Xiao, Z. Jan 1 2018 In : RSC Advances. 8, 22, p. 11871-11885 15 p.

Research output: Contribution to journalArticle

Cold rolling
Cells
Transcription
Tumors
Assays

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata

Tsurumi, F., Miura, Y., Saito, Y., Miyake, K., Fujie, T., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K. Apr 20 2018 In : Organic Letters. 20, 8, p. 2282-2286 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Subjective testing
Polyketides
nonanes
Monoterpenes

Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents

Wang, Y., Chen, S. R., Yang, X., Lee, K. H. & Cheng, Y. C. Feb 1 2018 In : Bioorganic and Medicinal Chemistry. 26, 3, p. 630-636 7 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Structure-Activity Relationship
Hepacivirus
Natural gas well logging
Virus Replication
1 Citations

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Zhang, Y., Yuan, Y. X., Goto, M., Guo, L. L., Li, X. N., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J. Mar 23 2018 In : Journal of Natural Products. 81, 3, p. 562-571 10 p.

Research output: Contribution to journalArticle

Tabernaemontana
Applicators
Alkaloids
KB Cells
P-Glycoprotein
2017
1 Citations

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K. Jan 27 2017 In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Double-Stranded DNA Breaks
Alkaloids
Tumor Cell Line
Tumors
1 Citations

Bioactive chemical constituents from the root bark of Morus australis

Liao, Y. R., Kuo, P. C., Tsai, W. J., Huang, G. J., Lee, K. H. & Wu, T. S. Jan 15 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

Morus
Platelets
Platelet Aggregation
Arachidonic Acid
Adenosine Diphosphate
3 Citations

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O’Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K. Apr 28 2017 In : Journal of Natural Products. 80, 4, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Antitumor Drug Screening Assays
Salicaceae
Clerodane Diterpenes
Plant Bark

Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives

Yang, C. J., Song, Z. L., Goto, M., Hsu, P. L., Zhang, X. S., Yang, Q. R., Liu, Y. Q., Wang, M. J., Morris-Natschke, S. L., Shang, X. F. & Lee, K. H. Jan 1 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 20, p. 4694-4697 4 p.

Research output: Contribution to journalArticle

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties

Yang, C. J., Song, Z. L., Goto, M., Liu, Y. Q., Hsieh, K. Y., Morris-Natschke, S. L., Zhao, Y. L., Zhang, J. X. & Lee, K. H. Jan 1 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 3959-3962 4 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Antitumor Drug Screening Assays
irinotecan
Piperazines
Amidines
2 Citations

Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds

Zhou, A., Yan, L., Lai, F., Chen, X., Goto, M., Lee, K. H. & Xiao, Z. Jan 1 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 15, p. 3326-3331 6 p.

Research output: Contribution to journalArticle

Slip forming
Gasohol
Triple Negative Breast Neoplasms
HCT116 Cells
Cell Line
2 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxicity
Derivatives
irinotecan
lissamine rhodamine B

Design, synthesis and structure-activity relationships of (±)-isochaihulactone derivatives

Zhao, Y., Liu, P. Y., Hsieh, K. Y., Hsu, P. L., Goto, M., Morris-Natschke, S. L., Harn, H. J. & Lee, K. H. Jan 1 2017 In : MedChemComm. 8, 11, p. 2040-2049 10 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
KB Cells
G2 Phase
P-Glycoprotein
Cell Cycle Checkpoints
Rilpivirine
Drug Dose Response Relationship
Slip forming
Aniline Compounds
Viral Drug Resistance
2 Citations

In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents

Cui, M. T., Jiang, L., Goto, M., Hsu, P. L., Li, L., Zhang, Q., Wei, L., Yuan, S. J., Hamel, E., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Jul 13 2017 In : Journal of Medicinal Chemistry. 60, 13, p. 5586-5598 13 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Molecular Docking Simulation
Quinazolines
Angiogenesis Inhibitors
Tubulin
2 Citations

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Hsieh, M. T., Chang, L. C., Hung, H. Y., Lin, H. Y., Shih, M. H., Tsai, C. H., Kuo, S. C. & Lee, K. H. May 5 2017 In : European Journal of Medicinal Chemistry. 131, p. 141-151 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Curcumin
Derivatives
Breast Neoplasms
Heterografts
1 Citations

Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions

Shiau, J. Y., Chang, Y. Q., Nakagawa-Goto, K., Lee, K. H. & Shyur, L. F. Jun 29 2017 In : Frontiers in Pharmacology. 8, JUN, 398

Research output: Contribution to journalArticle

DEET
Triple Negative Breast Neoplasms
Exosomes
Reactive Oxygen Species
Oxidative Stress
3 Citations

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Li, Q., Qu, F. L., Gao, Y., Jiang, Y. P., Rahman, K., Lee, K. H., Han, T. & Qin, L. P. Mar 6 2017 In : Journal of Ethnopharmacology. 199, p. 9-19 11 p.

Research output: Contribution to journalArticle

Piper
MAP Kinase Signaling System
Brain-Derived Neurotrophic Factor
Antidepressive Agents
Rodentia
6 Citations

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Vijaya Bhaskar Reddy, M., Hung, H. Y., Kuo, P. C., Huang, G. J., Chan, Y. Y., Huang, S. C., Wu, S. J., Morris-Natschke, S. L., Lee, K. H. & Wu, T. S. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1547-1550 4 p.

Research output: Contribution to journalArticle

Chalcones
Lead compounds
Chalcone
Macrophages
Peritoneal Macrophages
3 Citations

Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Yuan, Y. X., Zhang, Y., Guo, L. L., Wang, Y. H., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J. Sep 15 2017 In : Organic Letters. 19, 18, p. 4964-4967 4 p.

Research output: Contribution to journalArticle

Tabernaemontana
Applicators
alkaloids
Alkaloids
Vincristine

Total Synthesis of (+)-Medicarpin

Yang, X., Zhao, Y., Hsieh, M. T., Xin, G., Wu, R. T., Hsu, P. L., Horng, L. Y., Sung, H. C., Cheng, C. H. & Lee, K. H. Dec 22 2017 In : Journal of Natural Products. 80, 12, p. 3284-3288 5 p.

Research output: Contribution to journalArticle

Erythropoietin
Crystallites
Oxazolidinones
Research
medicarpin
2 Citations

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

Wang, Y., Lee, S., Ha, Y., Lam, W., Chen, S. R., Dutschman, G. E., Gullen, E. A., Grill, S. P., Cheng, Y., Fürstner, A., Francis, S., Baker, D. C., Yang, X., Lee, K. H. & Cheng, Y. C. Dec 1 2017 In : Scientific Reports. 7, 1, 10037

Research output: Contribution to journalArticle

1 Citations

Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia

Luo, P., Xia, W., Morris-Natschke, S. L., Lee, K. H., Zhao, Y., Gu, Q. & Xu, J. May 26 2017 In : Journal of Natural Products. 80, 5, p. 1558-1562 5 p.

Research output: Contribution to journalArticle

4 Citations

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

Xin, G., Wei, Z., Ji, C., Zheng, H., Gu, J., Ma, L., Huang, W., Morris-Natschke, S. L., Yeh, J. L., Zhang, R., Qin, C., Wen, L., Xing, Z., Cao, Y., Xia, Q., Li, K., Niu, H., Lee, K. H. & Huang, W. Jul 1 2017 In : Free Radical Biology and Medicine. 108, p. 247-257 11 p.

Research output: Contribution to journalArticle

Humulus
Platelet Activation
Platelets
Mitochondrial DNA
Thrombosis
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y. Mar 1 2016 In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
alkaloids
3 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K. Nov 23 2016 In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Contribution to journalArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Monomers
Cells
8 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H. Mar 1 2016 In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Contribution to journalArticle

Oxytropis
Alkaloids
Cells
Derivatives
Cell Line
11 Citations

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors

Dang, Z., Zhu, L., Lai, W., Bogerd, H., Lee, K. H., Huang, L. & Chen, C. H. Mar 10 2016 In : ACS Medicinal Chemistry Letters. 7, 3, p. 240-244 5 p.

Research output: Contribution to journalArticle

HIV Fusion Inhibitors
HIV-1
Derivatives
Cell Fusion
Fusion reactions
5 Citations

A novel plant sesquiterpene lactone derivative, DETD-35, Suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice

Feng, J. H., Nakagawa-Goto, K., Lee, K. H. & Shyur, L. F. Jun 1 2016 In : Molecular Cancer Therapeutics. 15, 6, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

Sesquiterpenes
Lactones
Melanoma
Growth
Mitogen-Activated Protein Kinase Kinases
2 Citations

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P. C., Wu, S. J., Hwang, T. L., Hung, H. Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E. J., Gu, Q., Lee, K. H. & Wu, T. S. Apr 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

Magnolia
Lignans
Anti-Inflammatory Agents
Derivatives
Pancreatic Elastase
8 Citations

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

Jiang, C., Luo, P., Zhao, Y., Hong, J., Morris-Natschke, S. L., Xu, J., Chen, C. H., Lee, K. H. & Gu, Q. Mar 25 2016 In : Journal of Natural Products. 79, 3, p. 578-583 6 p.

Research output: Contribution to journalArticle

Euphorbia
Lignans
Spectroscopic analysis
Enantiomers
Polyphenols
5 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H. Jun 10 2016 In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
irinotecan
Structure-Activity Relationship
7 Citations

Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii

Liu, S. N., Huang, D., Morris-Natschke, S. L., Ma, H., Liu, Z. H., Seeram, N. P., Xu, J., Lee, K. H. & Gu, Q. Dec 2 2016 In : Organic Letters. 18, 23, p. 6132-6135 4 p.

Research output: Contribution to journalArticle

Euphorbia
RANK Ligand
Diterpenes
Osteoclasts
Circular Dichroism
2 Citations

Four new diterpenoid alkaloids from Delphinium elatum

Wada, K., Asakawa, E., Tosho, Y., Nakata, A., Hasegawa, Y., Kaneda, K., Goto, M., Yamashita, H. & Lee, K. H. Sep 1 2016 In : Phytochemistry Letters. 17, p. 190-193 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
9 Citations

Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1

Zhao, Y., Gu, Q., Morris-Natschke, S. L., Chen, C. H. & Lee, K. H. Oct 13 2016 In : Journal of Medicinal Chemistry. 59, 19, p. 9262-9268 7 p.

Research output: Contribution to journalArticle

HIV-1
Biological Products
Skeleton
bevirimat
piperazine
8 Citations

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

Huang, W., Xin, G., Wei, Z., Ji, C., Zheng, H., Gu, J., Ma, L., Huang, W., Morris-Natschke, S. L., Yeh, J. L., Zhang, R., Qin, C., Wen, L., Xing, Z., Cao, Y., Xia, Q., Lu, Y., Li, K., Niu, H. & Lee, K. H. Nov 2 2016 In : Scientific Reports. 6, 36222

Research output: Contribution to journalArticle

Metformin
Platelet Activation
Mitochondrial DNA
Thrombosis
Diabetes Complications
5 Citations

Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus

Liu, N., Wei, L., Huang, L., Yu, F., Zheng, W., Qin, B., Zhu, D. Q., Morris-Natschke, S. L., Jiang, S., Chen, C. H., Lee, K. H. & Xie, L. Apr 28 2016 In : Journal of Medicinal Chemistry. 59, 8, p. 3689-3704 16 p.

Research output: Contribution to journalArticle

Rilpivirine
Reverse Transcriptase Inhibitors
HIV-1
Ligands
Viruses
8 Citations

Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

Nakagawa-Goto, K., Chen, J. Y., Cheng, Y. T., Lee, W. L., Takeya, M., Saito, Y., Lee, K. H. & Shyur, L. F. Jan 26 2016 (Accepted/In press) In : Molecular Oncology.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Sesquiterpenes
Lactones
Paclitaxel
Breast Neoplasms
2 Citations

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

Liu, L. N., Ran, J. Q., Li, L. J., Zhao, Y., Goto, M., Morris-Natschke, S. L., Lee, K. H., Zhao, B. Y. & Tan, C. J. Nov 16 2016 In : Tetrahedron Letters. 57, 46, p. 5047-5049 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
X-Ray Diffraction
15 Citations

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

Xiao, Z., Morris-Natschke, S. L. & Lee, K. H. Jan 1 2016 In : Medicinal Research Reviews. 36, 1, p. 32-91 60 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Biological Products
Computer-Aided Design
Pharmaceutical Chemistry
Drug Design
1 Citations

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

Wang, S. B., Cui, M. T., Wang, X. F., Ohkoshi, E., Goto, M., Yang, D. X., Li, L., Yuan, S., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Jul 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 13, p. 3083-3092 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Tumor Cell Line
Tumors
Cells
Quinazolines
4 Citations

Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells

Lin, Y. C., Chen, Y. F., Tseng, L. S., Lee, Y. H., Morris-Natschke, S. L., Kuo, S. C., Yang, N. S., Lee, K. H. & Huang, L. J. Mar 3 2016 In : European Journal of Medicinal Chemistry. 110, p. 98-114 17 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Colorectal Neoplasms
Cells
Derivatives
Indazoles
5 Citations

The application of NCTS (N-cyano-N-phenyl-p-toluenesulfonamide) in palladium-catalyzed cyanation of arenediazonium tetrafluoroborates and aryl halides

Li, J., Xu, W., Ding, J. & Lee, K. H. Mar 16 2016 In : Tetrahedron Letters. 57, 11, p. 1205-1209 5 p.

Research output: Contribution to journalArticle

Nitriles
Palladium
N-cyano-N-phenyl-p-methylbenzenesulfonamide