Research Output 1965 2017

Filter
Article
2017

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K. Jan 27 2017 In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Research - peer-reviewArticle

Alkaloids
DNA
Cryptocarya
Double-Stranded DNA Breaks
Tumors
1 Citations

Bioactive chemical constituents from the root bark of Morus australis

Liao, Y. R., Kuo, P. C., Tsai, W. J., Huang, G. J., Lee, K. H. & Wu, T. S. Jan 15 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 309-313 5 p.

Research output: Research - peer-reviewArticle

Morus
Platelet Aggregation
Arachidonic Acid
Adenosine Diphosphate
Platelets
1 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Research - peer-reviewArticle

Camptothecin
Derivatives
Cytotoxicity
Cells
irinotecan
1 Citations

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Hsieh, M. T., Chang, L. C., Hung, H. Y., Lin, H. Y., Shih, M. H., Tsai, C. H., Kuo, S. C. & Lee, K. H. May 5 2017 In : European Journal of Medicinal Chemistry. 131, p. 141-151 11 p.

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Curcumin
In Vitro Techniques
Derivatives
Breast Neoplasms
2 Citations

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Li, Q., Qu, F. L., Gao, Y., Jiang, Y. P., Rahman, K., Lee, K. H., Han, T. & Qin, L. P. Mar 6 2017 In : Journal of Ethnopharmacology. 199, p. 9-19 11 p.

Research output: Research - peer-reviewArticle

Piper
MAP Kinase Signaling System
Brain-Derived Neurotrophic Factor
Antidepressive Agents
Rodentia
3 Citations

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Vijaya Bhaskar Reddy, M., Hung, H. Y., Kuo, P. C., Huang, G. J., Chan, Y. Y., Huang, S. C., Wu, S. J., Morris-Natschke, S. L., Lee, K. H. & Wu, T. S. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1547-1550 4 p.

Research output: Research - peer-reviewArticle

Chalcones
Lead compounds
Chalcone
Macrophages
Condensation
2 Citations

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

Xin, G., Wei, Z., Ji, C., Zheng, H., Gu, J., Ma, L., Huang, W., Morris-Natschke, S. L., Yeh, J. L., Zhang, R., Qin, C., Wen, L., Xing, Z., Cao, Y., Xia, Q., Li, K., Niu, H., Lee, K. H. & Huang, W. Jul 1 2017 In : Free Radical Biology and Medicine. 108, p. 247-257 11 p.

Research output: Research - peer-reviewArticle

Humulus
Platelet Activation
Mitochondrial DNA
Thrombosis
Hemorrhage
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y. Mar 1 2016 In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Research - peer-reviewArticle

Quinolizidines
Alkaloids
Nuclear magnetic resonance
Derivatives
Experiments
1 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K. Nov 23 2016 In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Research - peer-reviewArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Cell Line
Neoplasms
6 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H. Mar 1 2016 In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Research - peer-reviewArticle

Oxytropis
Alkaloids
Cell Line
Neoplasms
matrine
8 Citations

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors

Dang, Z., Zhu, L., Lai, W., Bogerd, H., Lee, K. H., Huang, L. & Chen, C. H. Mar 10 2016 In : ACS Medicinal Chemistry Letters. 7, 3, p. 240-244 5 p.

Research output: Research - peer-reviewArticle

HIV Fusion Inhibitors
HIV-1
aloperine
Derivatives
Fusion reactions
5 Citations

A novel plant sesquiterpene lactone derivative, DETD-35, Suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice

Feng, J. H., Nakagawa-Goto, K., Lee, K. H. & Shyur, L. F. Jun 1 2016 In : Molecular Cancer Therapeutics. 15, 6, p. 1163-1176 14 p.

Research output: Research - peer-reviewArticle

Sesquiterpenes
Lactones
Melanoma
Growth
PLX4032
2 Citations

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P. C., Wu, S. J., Hwang, T. L., Hung, H. Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E. J., Gu, Q., Lee, K. H. & Wu, T. S. Apr 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Research - peer-reviewArticle

Magnolia
Lignans
Anti-Inflammatory Agents
Derivatives
Pancreatic Elastase
6 Citations

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

Jiang, C., Luo, P., Zhao, Y., Hong, J., Morris-Natschke, S. L., Xu, J., Chen, C. H., Lee, K. H. & Gu, Q. Mar 25 2016 In : Journal of Natural Products. 79, 3, p. 578-583 6 p.

Research output: Research - peer-reviewArticle

Lignans
Spectroscopic analysis
Enantiomers
Polyphenols
Antennas
4 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H. Jun 10 2016 In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Research - peer-reviewArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
Cells
Structure-Activity Relationship
4 Citations

Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii

Liu, S. N., Huang, D., Morris-Natschke, S. L., Ma, H., Liu, Z. H., Seeram, N. P., Xu, J., Lee, K. H. & Gu, Q. Dec 2 2016 In : Organic Letters. 18, 23, p. 6132-6135 4 p.

Research output: Research - peer-reviewArticle

Euphorbia
RANK Ligand
Diterpenes
Osteoclasts
Circular Dichroism
2 Citations

Four new diterpenoid alkaloids from Delphinium elatum

Wada, K., Asakawa, E., Tosho, Y., Nakata, A., Hasegawa, Y., Kaneda, K., Goto, M., Yamashita, H. & Lee, K. H. Sep 1 2016 In : Phytochemistry Letters. 17, p. 190-193 4 p.

Research output: Research - peer-reviewArticle

Delphinium elatum
diterpenoid alkaloids
Delphinium
Diterpenes
Alkaloids
6 Citations

Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1

Zhao, Y., Gu, Q., Morris-Natschke, S. L., Chen, C. H. & Lee, K. H. Oct 13 2016 In : Journal of Medicinal Chemistry. 59, 19, p. 9262-9268 7 p.

Research output: Research - peer-reviewArticle

HIV-1
bevirimat
Biological Products
Skeleton
piperazine
7 Citations

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

Huang, W., Xin, G., Wei, Z., Ji, C., Zheng, H., Gu, J., Ma, L., Huang, W., Morris-Natschke, S. L., Yeh, J. L., Zhang, R., Qin, C., Wen, L., Xing, Z., Cao, Y., Xia, Q., Lu, Y., Li, K., Niu, H. & Lee, K. H. Nov 2 2016 In : Scientific Reports. 6, 36222

Research output: Research - peer-reviewArticle

Metformin
Platelet Activation
Mitochondrial DNA
Thrombosis
Diabetes Complications
4 Citations

Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus

Liu, N., Wei, L., Huang, L., Yu, F., Zheng, W., Qin, B., Zhu, D. Q., Morris-Natschke, S. L., Jiang, S., Chen, C. H., Lee, K. H. & Xie, L. Apr 28 2016 In : Journal of Medicinal Chemistry. 59, 8, p. 3689-3704 16 p.

Research output: Research - peer-reviewArticle

Rilpivirine
Reverse Transcriptase Inhibitors
HIV-1
Ligands
Viruses
7 Citations

Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

Nakagawa-Goto, K., Chen, J. Y., Cheng, Y. T., Lee, W. L., Takeya, M., Saito, Y., Lee, K. H. & Shyur, L. F. Jan 26 2016 (Accepted/In press) In : Molecular Oncology.

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Sesquiterpenes
Lactones
Breast Neoplasms
deoxyelephantopin
2 Citations

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

Liu, L. N., Ran, J. Q., Li, L. J., Zhao, Y., Goto, M., Morris-Natschke, S. L., Lee, K. H., Zhao, B. Y. & Tan, C. J. Nov 16 2016 In : Tetrahedron Letters. 57, 46, p. 5047-5049 3 p.

Research output: Research - peer-reviewArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
X-Ray Diffraction
10 Citations

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

Xiao, Z., Morris-Natschke, S. L. & Lee, K. H. Jan 1 2016 In : Medicinal Research Reviews. 36, 1, p. 32-91 60 p.

Research output: Research - peer-reviewArticle

Pharmaceutical Preparations
Biological Products
Computer-Aided Design
Pharmaceutical Chemistry
Drug Design
1 Citations

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

Wang, S. B., Cui, M. T., Wang, X. F., Ohkoshi, E., Goto, M., Yang, D. X., Li, L., Yuan, S., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Jul 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 13, p. 3083-3092 10 p.

Research output: Research - peer-reviewArticle

Protein-Tyrosine Kinases
Tumors
Cells
Tumor Cell Line
Quinazolines
3 Citations

Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells

Lin, Y. C., Chen, Y. F., Tseng, L. S., Lee, Y. H., Morris-Natschke, S. L., Kuo, S. C., Yang, N. S., Lee, K. H. & Huang, L. J. Mar 3 2016 In : European Journal of Medicinal Chemistry. 110, p. 98-114 17 p.

Research output: Research - peer-reviewArticle

Structure-Activity Relationship
Colorectal Neoplasms
alpha-carboline
Cells
Derivatives
3 Citations

The application of NCTS (N-cyano-N-phenyl-p-toluenesulfonamide) in palladium-catalyzed cyanation of arenediazonium tetrafluoroborates and aryl halides

Li, J., Xu, W., Ding, J. & Lee, K. H. Mar 16 2016 In : Tetrahedron Letters. 57, 11, p. 1205-1209 5 p.

Research output: Research - peer-reviewArticle

Nitriles
Palladium
N-cyano-N-phenyl-p-methylbenzenesulfonamide

Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata

Morita, C., Kobayashi, Y., Saito, Y., Miyake, K., Tokuda, H., Suzuki, N., Ichiishi, E., Lee, K. H. & Nakagawa-Goto, K. Nov 23 2016 In : Journal of Natural Products. 79, 11, p. 2890-2897 8 p.

Research output: Research - peer-reviewArticle

Tumors
Monomers
Chemical activation
acetophenone
Epstein-Barr virus early antigen
2 Citations

Triethylated chromones with substituted naphthalenes as tubulin inhibitors

Nakagawa-Goto, K., Taniguchi, Y., Watanabe, Y., Oda, A., Ohkoshi, E., Hamel, E., Lee, K. H. & Goto, M. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 22, p. 6048-6057 10 p.

Research output: Research - peer-reviewArticle

Tubulin Modulators
Naphthalenes
Chromones
Tubulin
Tumors
2015
15 Citations

3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease

Wu, T., Jiang, C., Wang, L., Morris-Natschke, S. L., Miao, H., Gu, L., Xu, J., Lee, K. H. & Gu, Q. Jul 24 2015 In : Journal of Natural Products. 78, 7, p. 1593-1599 7 p.

Research output: Research - peer-reviewArticle

Flavonoids
Agglomeration
Derivatives
Chrysanthemum
Alzheimer Disease
8 Citations

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J. Jan 1 2015 In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Research - peer-reviewArticle

Lung Neoplasms
Growth
Neoplasms
betulinic acid
Endoplasmic Reticulum Stress
1 Citations

Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines

Liu, C. Y., Cheng, Y. Y., Chang, L. C., Huang, L. J., Chou, L. C., Huang, C. H., Tsai, M. T., Liao, C. C., Hsu, M. H., Lin, H. Y., Wu, T. S., Wen, Y. F., Zhao, Y., Kuo, S. C. & Lee, K. H. Jan 27 2015 In : European Journal of Medicinal Chemistry. 90, p. 775-787 13 p.

Research output: Research - peer-reviewArticle

Antineoplastic Agents
Cell Line
Neoplasms
Cells
Prodrugs
13 Citations

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction

Song, Z. L., Chen, H. L., Wang, Y. H., Goto, M., Gao, W. J., Cheng, P. L., Morris-Natschke, S. L., Liu, Y. Q., Zhu, G. X., Wang, M. J. & Lee, K. H. May 30 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 13, p. 2690-2693 4 p.

Research output: Research - peer-reviewArticle

Camptothecin
Polyethylene glycols
Cells
Derivatives
irinotecan
18 Citations

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

Nakagawa-Goto, K., Oda, A., Hamel, E., Ohkoshi, E., Lee, K. H. & Goto, M. Mar 12 2015 In : Journal of Medicinal Chemistry. 58, 5, p. 2378-2389 12 p.

Research output: Research - peer-reviewArticle

Tubulin Modulators
Tubulin
Microtubules
Interphase
Hydrogen
1 Citations

Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9

Gao, J., Fang, C., Xiao, Z., Huang, L., Chen, C. H., Wang, L. T. & Lee, K. H. Mar 1 2015 In : MedChemComm. 6, 3, p. 444-454 11 p.

Research output: Research - peer-reviewArticle

Cyclin-Dependent Kinase 9
Diamines
Assays
alvocidib
lissamine rhodamine B
3 Citations

Diterpenoids from the stems of Tripterygium hypoglaucum (Celastraceae) and cytotoxic evaluation

Li, X. L., Gao, L. H., Li, H. M., Wang, L. T., Lee, K. H. & Li, R. T. Jan 1 2015 In : Phytochemistry Letters. 12, p. 84-89 6 p.

Research output: Research - peer-reviewArticle

Celastraceae
Tripterygium
Trientine
Diterpenes
Cell Line
6 Citations

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

Chao, M. W., Wang, L. T., Lai, C. Y., Yang, X. M., Cheng, Y. W., Lee, K. H., Pan, S. L. & Teng, C. M. Jan 1 2015 In : Oncotarget. 6, 27, p. 24092-24104 13 p.

Research output: Research - peer-reviewArticle

Colorectal Neoplasms
Carrier Proteins
Survival
YXM110
Therapeutics
6 Citations

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

Wada, K., Ohkoshi, E., Zhao, Y., Goto, M., Morris-Natschke, S. L. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 7, p. 1525-1531 7 p.

Research output: Research - peer-reviewArticle

Aconitum
Diterpenes
Alkaloids
Vincristine
Tumors
3 Citations

Flavonoids isolated from heat-processed Epimedium koreanum and their anti-HIV-1 activities

Li, H. M., Zhou, C., Chen, C. H., Li, R. T. & Lee, K. H. Aug 1 2015 In : Helvetica Chimica Acta. 98, 8, p. 1177-1187 11 p.

Research output: Research - peer-reviewArticle

Epimedium
Apigenin
Phytochemicals
Glycosides
Flavonoids

Gnidimacrin, a potent anti-HIV diterpene, can eliminate latent HIV-1 ex vivo by activation of protein kinase Cβ

Lai, W., Huang, L., Zhu, L., Ferrari, G., Chan, C., Li, W., Lee, K. H. & Chen, C. H. Nov 12 2015 In : Journal of Medicinal Chemistry. 58, 21, p. 8638-8646 9 p.

Research output: Research - peer-reviewArticle

Diterpenes
Protein Kinases
HIV-1
HIV
gnidimacrin
16 Citations

Neo -clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication

Wu, T., Wang, Q., Jiang, C., Morris-Natschke, S. L., Cui, H., Wang, Y., Yan, Y., Xu, J., Lee, K. H. & Gu, Q. Mar 27 2015 In : Journal of Natural Products. 78, 3, p. 500-509 10 p.

Research output: Research - peer-reviewArticle

Scutellaria
Clerodane Diterpenes
Diterpenes
Virus Replication
Human Herpesvirus 4
8 Citations

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Research - peer-reviewArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Adenocarcinoma of lung
Pharmaceutical Preparations
9 Citations

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

Wang, S. B., Wang, X. F., Qin, B., Ohkoshi, E., Hsieh, K. Y., Hamel, E., Cui, M. T., Zhu, D. Q., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Apr 28 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5740-5747 8 p.

Research output: Research - peer-reviewArticle

Tubulin Modulators
Colchicine
Tubulin
Assays
Pharmaceutical Preparations
43 Citations

Perspectives on Biologically Active Camptothecin Derivatives

Liu, Y. Q., Li, W. Q., Morris-Natschke, S. L., Qian, K., Yang, L., Zhu, G. X., Wu, X. B., Chen, A. L., Zhang, S. Y., Nan, X. & Lee, K. H. Jan 1 2015 In : Medicinal Research Reviews. 35, 4, p. 753-789 37 p.

Research output: Research - peer-reviewArticle

Camptothecin
irinotecan
Topotecan
Type I DNA Topoisomerase
Pharmaceutical Chemistry
3 Citations

Phenolic diterpenoid derivatives as anti-influenza a virus agents

Dang, Z., Jung, K., Zhu, L., Xie, H., Lee, K. H., Chen, C. H. & Huang, L. Mar 12 2015 In : ACS Medicinal Chemistry Letters. 6, 3, p. 355-358 4 p.

Research output: Research - peer-reviewArticle

Diterpenes
Influenza A virus
Orthomyxoviridae
Pharmaceutical Preparations
podocarpic acid
35 Citations

Recent Progress on C-4-Modified Podophyllotoxin Analogs as Potent Antitumor Agents

Liu, Y. Q., Tian, J., Qian, K., Zhao, X. B., Morris-Natschke, S. L., Yang, L., Nan, X., Tian, X. & Lee, K. H. Jan 1 2015 In : Medicinal Research Reviews. 35, 1, p. 1-62 62 p.

Research output: Research - peer-reviewArticle

Podophyllotoxin
Antineoplastic Agents
Etoposide
Structure-Activity Relationship
Clinical Trials
3 Citations

Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum

Yuan, W. H., Goto, M., Hsieh, K. Y., Yuan, B., Zhao, Y., Morris-Natschke, S. L. & Lee, K. H. Dec 2 2015 In : Journal of Asian Natural Products Research. 17, 12, p. 1239-1244 6 p.

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Sesquiterpenes
Penicillium
X-Ray Diffraction
Radiation
3 Citations

Six new norditerpenoid alkaloids from Delphinium elatum

Wada, K., Chiba, R., Kanazawa, R., Matsuoka, K., Suzuki, M., Ikuta, M., Goto, M., Yamashita, H. & Lee, K. H. Jan 1 2015 In : Phytochemistry Letters. 12, p. 79-83 5 p.

Research output: Research - peer-reviewArticle

Delphinium
Diterpenes
Alkaloids
Delphinium elatum
diterpenoid alkaloids
1 Citations

Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme

Yan, M., Lu, Y., Chen, C. H., Zhao, Y., Lee, K. H. & Chen, D. F. Nov 25 2015 In : Journal of Natural Products. 78, 11, p. 2712-2718 7 p.

Research output: Research - peer-reviewArticle

Diterpenes
HIV
RHO(D) antibody
mezerein
Spectroscopic analysis
3 Citations

Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives

Fang, S., Chen, L., Yu, M., Cheng, B., Lin, Y., Morris-Natschke, S. L., Lee, K. H., Gu, Q. & Xu, J. Apr 28 2015 In : Organic and Biomolecular Chemistry. 13, 16, p. 4714-4726 13 p.

Research output: Research - peer-reviewArticle

HeLa Cells
Cell Line
6-acrylic phenethyl ester-2-pyranone
cultured cells
esters
4 Citations

Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

Chen, Y. F., Lin, Y. C., Morris-Natschke, S. L., Wei, C. F., Shen, T. C., Lin, H. Y., Hsu, M. H., Chou, L. C., Zhao, Y., Kuo, S. C., Lee, K. H. & Huang, L. J. Jan 1 2015 In : British Journal of Pharmacology. 172, 5, p. 1195-1221 27 p.

Research output: Research - peer-reviewArticle

Apoptosis
Neoplasms
Caspase 8
Microtubules
Caspase 3