Research Output 1965 2017

2017

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K. Jan 27 2017 In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Double-Stranded DNA Breaks
Alkaloids
Tumor Cell Line
Tumors
1 Citations

Bioactive chemical constituents from the root bark of Morus australis

Liao, Y. R., Kuo, P. C., Tsai, W. J., Huang, G. J., Lee, K. H. & Wu, T. S. Jan 15 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

Morus
Platelets
Platelet Aggregation
Arachidonic Acid
Adenosine Diphosphate
2 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxicity
Derivatives
irinotecan
lissamine rhodamine B
Staurosporine
Pharmaceutical Chemistry
Protein-Tyrosine Kinases
Paclitaxel
Publications
2 Citations

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Hsieh, M. T., Chang, L. C., Hung, H. Y., Lin, H. Y., Shih, M. H., Tsai, C. H., Kuo, S. C. & Lee, K. H. May 5 2017 In : European Journal of Medicinal Chemistry. 131, p. 141-151 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Curcumin
Derivatives
Breast Neoplasms
Heterografts
3 Citations

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Li, Q., Qu, F. L., Gao, Y., Jiang, Y. P., Rahman, K., Lee, K. H., Han, T. & Qin, L. P. Mar 6 2017 In : Journal of Ethnopharmacology. 199, p. 9-19 11 p.

Research output: Contribution to journalArticle

Piper
MAP Kinase Signaling System
Brain-Derived Neurotrophic Factor
Antidepressive Agents
Rodentia
5 Citations

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Vijaya Bhaskar Reddy, M., Hung, H. Y., Kuo, P. C., Huang, G. J., Chan, Y. Y., Huang, S. C., Wu, S. J., Morris-Natschke, S. L., Lee, K. H. & Wu, T. S. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1547-1550 4 p.

Research output: Contribution to journalArticle

Chalcones
Lead compounds
Chalcone
Macrophages
Peritoneal Macrophages
4 Citations

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

Xin, G., Wei, Z., Ji, C., Zheng, H., Gu, J., Ma, L., Huang, W., Morris-Natschke, S. L., Yeh, J. L., Zhang, R., Qin, C., Wen, L., Xing, Z., Cao, Y., Xia, Q., Li, K., Niu, H., Lee, K. H. & Huang, W. Jul 1 2017 In : Free Radical Biology and Medicine. 108, p. 247-257 11 p.

Research output: Contribution to journalArticle

Humulus
Platelet Activation
Platelets
Mitochondrial DNA
Thrombosis
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y. Mar 1 2016 In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
alkaloids
1 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K. Nov 23 2016 In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Contribution to journalArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Monomers
Cells
7 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H. Mar 1 2016 In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Contribution to journalArticle

Oxytropis
Alkaloids
Cells
Derivatives
Cell Line
11 Citations

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors

Dang, Z., Zhu, L., Lai, W., Bogerd, H., Lee, K. H., Huang, L. & Chen, C. H. Mar 10 2016 In : ACS Medicinal Chemistry Letters. 7, 3, p. 240-244 5 p.

Research output: Contribution to journalArticle

HIV Fusion Inhibitors
HIV-1
Derivatives
Cell Fusion
Fusion reactions
5 Citations

A novel plant sesquiterpene lactone derivative, DETD-35, Suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice

Feng, J. H., Nakagawa-Goto, K., Lee, K. H. & Shyur, L. F. Jun 1 2016 In : Molecular Cancer Therapeutics. 15, 6, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

Sesquiterpenes
Lactones
Melanoma
Growth
Mitogen-Activated Protein Kinase Kinases
2 Citations

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P. C., Wu, S. J., Hwang, T. L., Hung, H. Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E. J., Gu, Q., Lee, K. H. & Wu, T. S. Apr 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

Magnolia
Lignans
Anti-Inflammatory Agents
Derivatives
Pancreatic Elastase
8 Citations

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

Jiang, C., Luo, P., Zhao, Y., Hong, J., Morris-Natschke, S. L., Xu, J., Chen, C. H., Lee, K. H. & Gu, Q. Mar 25 2016 In : Journal of Natural Products. 79, 3, p. 578-583 6 p.

Research output: Contribution to journalArticle

Euphorbia
Lignans
Spectroscopic analysis
Enantiomers
Polyphenols
24 Citations

Clerodane diterpenes: Sources, structures, and biological activities

Li, R., Morris-Natschke, S. L. & Lee, K. H. Oct 1 2016 In : Natural Product Reports. 33, 10, p. 1166-1226 61 p.

Research output: Contribution to journalReview article

Clerodane Diterpenes
Bioactivity
Opioid Receptors
Salvia
Diterpenes
5 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H. Jun 10 2016 In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
irinotecan
Structure-Activity Relationship
5 Citations

Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii

Liu, S. N., Huang, D., Morris-Natschke, S. L., Ma, H., Liu, Z. H., Seeram, N. P., Xu, J., Lee, K. H. & Gu, Q. Dec 2 2016 In : Organic Letters. 18, 23, p. 6132-6135 4 p.

Research output: Contribution to journalArticle

Euphorbia
RANK Ligand
Diterpenes
Osteoclasts
Circular Dichroism
2 Citations

Four new diterpenoid alkaloids from Delphinium elatum

Wada, K., Asakawa, E., Tosho, Y., Nakata, A., Hasegawa, Y., Kaneda, K., Goto, M., Yamashita, H. & Lee, K. H. Sep 1 2016 In : Phytochemistry Letters. 17, p. 190-193 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
7 Citations

Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1

Zhao, Y., Gu, Q., Morris-Natschke, S. L., Chen, C. H. & Lee, K. H. Oct 13 2016 In : Journal of Medicinal Chemistry. 59, 19, p. 9262-9268 7 p.

Research output: Contribution to journalArticle

HIV-1
Biological Products
Skeleton
bevirimat
piperazine
7 Citations

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

Huang, W., Xin, G., Wei, Z., Ji, C., Zheng, H., Gu, J., Ma, L., Huang, W., Morris-Natschke, S. L., Yeh, J. L., Zhang, R., Qin, C., Wen, L., Xing, Z., Cao, Y., Xia, Q., Lu, Y., Li, K., Niu, H. & Lee, K. H. Nov 2 2016 In : Scientific Reports. 6, 36222

Research output: Contribution to journalArticle

Metformin
Platelet Activation
Mitochondrial DNA
Thrombosis
Diabetes Complications
4 Citations

Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus

Liu, N., Wei, L., Huang, L., Yu, F., Zheng, W., Qin, B., Zhu, D. Q., Morris-Natschke, S. L., Jiang, S., Chen, C. H., Lee, K. H. & Xie, L. Apr 28 2016 In : Journal of Medicinal Chemistry. 59, 8, p. 3689-3704 16 p.

Research output: Contribution to journalArticle

Rilpivirine
Reverse Transcriptase Inhibitors
HIV-1
Ligands
Viruses
8 Citations

Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

Nakagawa-Goto, K., Chen, J. Y., Cheng, Y. T., Lee, W. L., Takeya, M., Saito, Y., Lee, K. H. & Shyur, L. F. Jan 26 2016 (Accepted/In press) In : Molecular Oncology.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Sesquiterpenes
Lactones
Paclitaxel
Breast Neoplasms
2 Citations

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

Liu, L. N., Ran, J. Q., Li, L. J., Zhao, Y., Goto, M., Morris-Natschke, S. L., Lee, K. H., Zhao, B. Y. & Tan, C. J. Nov 16 2016 In : Tetrahedron Letters. 57, 46, p. 5047-5049 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
X-Ray Diffraction
14 Citations

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

Xiao, Z., Morris-Natschke, S. L. & Lee, K. H. Jan 1 2016 In : Medicinal Research Reviews. 36, 1, p. 32-91 60 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Biological Products
Computer-Aided Design
Pharmaceutical Chemistry
Drug Design
1 Citations

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

Wang, S. B., Cui, M. T., Wang, X. F., Ohkoshi, E., Goto, M., Yang, D. X., Li, L., Yuan, S., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Jul 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 13, p. 3083-3092 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Tumor Cell Line
Tumors
Cells
Quinazolines
4 Citations

Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells

Lin, Y. C., Chen, Y. F., Tseng, L. S., Lee, Y. H., Morris-Natschke, S. L., Kuo, S. C., Yang, N. S., Lee, K. H. & Huang, L. J. Mar 3 2016 In : European Journal of Medicinal Chemistry. 110, p. 98-114 17 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Colorectal Neoplasms
Cells
Derivatives
Indazoles
5 Citations

The application of NCTS (N-cyano-N-phenyl-p-toluenesulfonamide) in palladium-catalyzed cyanation of arenediazonium tetrafluoroborates and aryl halides

Li, J., Xu, W., Ding, J. & Lee, K. H. Mar 16 2016 In : Tetrahedron Letters. 57, 11, p. 1205-1209 5 p.

Research output: Contribution to journalArticle

Nitriles
Palladium
N-cyano-N-phenyl-p-methylbenzenesulfonamide

Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata

Morita, C., Kobayashi, Y., Saito, Y., Miyake, K., Tokuda, H., Suzuki, N., Ichiishi, E., Lee, K. H. & Nakagawa-Goto, K. Nov 23 2016 In : Journal of Natural Products. 79, 11, p. 2890-2897 8 p.

Research output: Contribution to journalArticle

Rutaceae
Prenylation
Tumors
Monomers
Chemical activation
3 Citations

Triethylated chromones with substituted naphthalenes as tubulin inhibitors

Nakagawa-Goto, K., Taniguchi, Y., Watanabe, Y., Oda, A., Ohkoshi, E., Hamel, E., Lee, K. H. & Goto, M. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 22, p. 6048-6057 10 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Naphthalenes
Chromones
Tubulin
Colchicine
2015
15 Citations

3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease

Wu, T., Jiang, C., Wang, L., Morris-Natschke, S. L., Miao, H., Gu, L., Xu, J., Lee, K. H. & Gu, Q. Jul 24 2015 In : Journal of Natural Products. 78, 7, p. 1593-1599 7 p.

Research output: Contribution to journalArticle

Chrysanthemum
Flavonoids
Alzheimer Disease
Agglomeration
Cytotoxicity
10 Citations

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J. Jan 1 2015 In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Endoplasmic Reticulum Stress
Cyclin A2
Growth
Neoplasm Metastasis
1 Citations

Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines

Liu, C. Y., Cheng, Y. Y., Chang, L. C., Huang, L. J., Chou, L. C., Huang, C. H., Tsai, M. T., Liao, C. C., Hsu, M. H., Lin, H. Y., Wu, T. S., Wen, Y. F., Zhao, Y., Kuo, S. C. & Lee, K. H. Jan 27 2015 In : European Journal of Medicinal Chemistry. 90, p. 775-787 13 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Cells
Cell Line
Neoplasms
Prodrugs
14 Citations

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction

Song, Z. L., Chen, H. L., Wang, Y. H., Goto, M., Gao, W. J., Cheng, P. L., Morris-Natschke, S. L., Liu, Y. Q., Zhu, G. X., Wang, M. J. & Lee, K. H. May 30 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 13, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

irinotecan
Camptothecin
Tumor Cell Line
Polyethylene glycols
Cells
24 Citations

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

Nakagawa-Goto, K., Oda, A., Hamel, E., Ohkoshi, E., Lee, K. H. & Goto, M. Mar 12 2015 In : Journal of Medicinal Chemistry. 58, 5, p. 2378-2389 12 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Tubulin
Microtubules
Interphase
Hydrogen
1 Citations

Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9

Gao, J., Fang, C., Xiao, Z., Huang, L., Chen, C. H., Wang, L. T. & Lee, K. H. Mar 1 2015 In : MedChemComm. 6, 3, p. 444-454 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 9
Diamines
alvocidib
lissamine rhodamine B
Assays
3 Citations

Diterpenoids from the stems of Tripterygium hypoglaucum (Celastraceae) and cytotoxic evaluation

Li, X. L., Gao, L. H., Li, H. M., Wang, L. T., Lee, K. H. & Li, R. T. Jan 1 2015 In : Phytochemistry Letters. 12, p. 84-89 6 p.

Research output: Contribution to journalArticle

Tripterygium
Celastraceae
Trientine
glycols
Spectroscopic analysis
6 Citations

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

Chao, M. W., Wang, L. T., Lai, C. Y., Yang, X. M., Cheng, Y. W., Lee, K. H., Pan, S. L. & Teng, C. M. Jan 1 2015 In : Oncotarget. 6, 27, p. 24092-24104 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Carrier Proteins
Survival
Vascular Endothelial Growth Factor A
YXM110
8 Citations

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

Wada, K., Ohkoshi, E., Zhao, Y., Goto, M., Morris-Natschke, S. L. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 7, p. 1525-1531 7 p.

Research output: Contribution to journalArticle

Aconitum
Diterpenes
Alkaloids
Vincristine
Tumors
3 Citations

Flavonoids isolated from heat-processed Epimedium koreanum and their anti-HIV-1 activities

Li, H. M., Zhou, C., Chen, C. H., Li, R. T. & Lee, K. H. Aug 1 2015 In : Helvetica Chimica Acta. 98, 8, p. 1177-1187 11 p.

Research output: Contribution to journalArticle

Epimedium
Apigenin
Glycosides
Flavonoids
glucosides
1 Citations

Gnidimacrin, a potent anti-HIV diterpene, can eliminate latent HIV-1 ex vivo by activation of protein kinase Cβ

Lai, W., Huang, L., Zhu, L., Ferrari, G., Chan, C., Li, W., Lee, K. H. & Chen, C. H. Nov 12 2015 In : Journal of Medicinal Chemistry. 58, 21, p. 8638-8646 9 p.

Research output: Contribution to journalArticle

Diterpenes
Protein Kinases
HIV-1
HIV
Histone Deacetylase Inhibitors
16 Citations

Neo -clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication

Wu, T., Wang, Q., Jiang, C., Morris-Natschke, S. L., Cui, H., Wang, Y., Yan, Y., Xu, J., Lee, K. H. & Gu, Q. Mar 27 2015 In : Journal of Natural Products. 78, 3, p. 500-509 10 p.

Research output: Contribution to journalArticle

Scutellaria
Clerodane Diterpenes
Diterpenes
Virus Replication
Human Herpesvirus 4
10 Citations

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Pharmaceutical Preparations
Phosphorylation
9 Citations

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

Wang, S. B., Wang, X. F., Qin, B., Ohkoshi, E., Hsieh, K. Y., Hamel, E., Cui, M. T., Zhu, D. Q., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Apr 28 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5740-5747 8 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Colchicine
Tubulin
Antineoplastic Agents
Assays
47 Citations

Perspectives on Biologically Active Camptothecin Derivatives

Liu, Y. Q., Li, W. Q., Morris-Natschke, S. L., Qian, K., Yang, L., Zhu, G. X., Wu, X. B., Chen, A. L., Zhang, S. Y., Nan, X. & Lee, K. H. Jan 1 2015 In : Medicinal Research Reviews. 35, 4, p. 753-789 37 p.

Research output: Contribution to journalArticle

Camptothecin
irinotecan
Topotecan
Type I DNA Topoisomerase
Pharmaceutical Chemistry
5 Citations

Phenolic diterpenoid derivatives as anti-influenza a virus agents

Dang, Z., Jung, K., Zhu, L., Xie, H., Lee, K. H., Chen, C. H. & Huang, L. Mar 12 2015 In : ACS Medicinal Chemistry Letters. 6, 3, p. 355-358 4 p.

Research output: Contribution to journalArticle

Diterpenes
Influenza A virus
Orthomyxoviridae
Viruses
Derivatives
39 Citations

Recent Progress on C-4-Modified Podophyllotoxin Analogs as Potent Antitumor Agents

Liu, Y. Q., Tian, J., Qian, K., Zhao, X. B., Morris-Natschke, S. L., Yang, L., Nan, X., Tian, X. & Lee, K. H. Jan 1 2015 In : Medicinal Research Reviews. 35, 1, p. 1-62 62 p.

Research output: Contribution to journalArticle

Podophyllotoxin
Antineoplastic Agents
Etoposide
Structure-Activity Relationship
Clinical Trials
3 Citations

Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum

Yuan, W. H., Goto, M., Hsieh, K. Y., Yuan, B., Zhao, Y., Morris-Natschke, S. L. & Lee, K. H. Dec 2 2015 In : Journal of Asian Natural Products Research. 17, 12, p. 1239-1244 6 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Sesquiterpenes
Penicillium
Cytotoxicity
X-Ray Diffraction
3 Citations

Six new norditerpenoid alkaloids from Delphinium elatum

Wada, K., Chiba, R., Kanazawa, R., Matsuoka, K., Suzuki, M., Ikuta, M., Goto, M., Yamashita, H. & Lee, K. H. Jan 1 2015 In : Phytochemistry Letters. 12, p. 79-83 5 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
1 Citations

Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme

Yan, M., Lu, Y., Chen, C. H., Zhao, Y., Lee, K. H. & Chen, D. F. Nov 25 2015 In : Journal of Natural Products. 78, 11, p. 2712-2718 7 p.

Research output: Contribution to journalArticle

Diterpenes
HIV
Spectroscopic analysis
Bioassay
Fractionation