• 8775 Citations
  • 48 h-Index
1980 …2018
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  • 2 Similar Profiles
Hepatocytes Medicine & Life Sciences
Liver Medicine & Life Sciences
Rats Chemical Compounds
Pharmacokinetics Medicine & Life Sciences
Bile Acids and Salts Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Taurocholic Acid Medicine & Life Sciences
Bile Medicine & Life Sciences

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Projects 1991 2018

North Carolina Translational & Clinical Sciences Institute (NC TraCS)

Fraser, M. W., Sims, C. E., Mostafa, J., Wohl, D. A., Weber, D. J., Bangdiwala, S. I., Carey, T. S., Phillips, C. L., Miller, W. C., Jonsson-Funk, M. L., Jones, S. W., Beck, J. D., Mauriello, S. M., Retsch-Bogart, G. Z., Falk, R. J., Jordan, J. M., Ammerman, A. S., Carpenter, W. R., Edwards, L. J., Garrett, J. M., Coyne-Beasley, T., Henderson, G. E., Stewart, P. W., Davis, A. M., Evans, J. P., Gilmore, J. H., Gaynes, B. N., Brookhart, M. A., Sleath, B. L., Offenbacher, S., Marzluff, W. F., Topal, M. D., Orringer, E. P., Qaqish, B. F., Leigh, M. W., Peden, D. B., Buse, J. B., Tolleson-Rinehart, S., Ransohoff, D. F., Funkhouser, W. K., Egan, T. M., Cai, J., Truong, K. N., Brouwer, K. L. R., Boucher, R. C., Sen, P. K., Reuland, D. S., Donahue, K. E., Weiner, B. J., Watkins, P. B., Lin, W., Perrin, E. M., Magnuson, T. R., Corbie-Smith, G. M., Duncan, J. A., Weinberger, M., Zeng, D., Meshnick, S. R., Ibrahim, J. G., Dilworth-Anderson, P., Johnson, G. L., Walker, R. L., Viera, A. J., Glickman, S. W., Halladay, J. R., Rennie, S. M., Key, N. S., Rubin, J. E., Kosorok, M. R., Zhu, H., Bair, E., Henning, S. J., Mackman, N., Fine, J. P., Mayer-Davis, E. J., Stuermer, T. H. R., Davis, R. M., Park, S. I., Wu, M. C., Carpenter, D. M., Fang, G., Weaver, M. A., Lin, F., Davis, S. M., Shea, C. M., Carter-Edwards, L., Dennis, A. M., Fisher, J. A., Golightly, Y. M., Hingtgen, S. D., Smith, A. M., Tan, J. T., Asher, G. N., Barritt, A. S., Blouin, R., Buchbinder, M., Hurt, C., Juengst, E. T., Mendoza, L. C., Reeve, B., Roman Isler, M. D., Wood, W. A., Ahalt, S., Agans, R. P., Dave, G. J., Lightfoot, A. F., Zhou, H., Skinner, A. C., Wilhelmsen, K. C., Song, L., Fischer, W. A., Peery, A. F., Powers, K. A., Ryan, A. E., Otey, C. A., Donaldson, S. H., Leeman, J., Kashuba, A. D., Gomez, S. M., Chung, A. E., Meyer, A. M., Parrott, M. C., Toles, M. P., Schmitt, C., Nichols, H. B. & Moran, T. P.

NIH National Center for Advancing Translational Sciences (NCATS)

9/26/134/30/18

Project: Research project

Annual Reports

Research Output 1980 2018

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

Karageorgis, A., Lenhard, S. C., Yerby, B., Forsgren, M. F., Liachenko, S., Johansson, E., Pilling, M. A., Peterson, R. A., Yang, X., Williams, D. P., Ungersma, S. E., Morgan, R. E., Brouwer, K. L. R., Jucker, B. M. & Hockings, P. D., May 1 2018, In : PLoS One. 13, 5, e0197213

Research output: Contribution to journalArticle

Slip forming
Thallium alloys
rifampicin
Rifampin
magnetic resonance imaging

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

Zhu, P., Zhang, J., Chen, Y., Yin, S., Su, M., Xie, G., Brouwer, K. L. R., Liu, C., Lan, K. & Jia, W., Jun 16 2018, (Accepted/In press) In : Analytical and Bioanalytical Chemistry. p. 1-14 14 p.

Research output: Contribution to journalArticle

Metabolome
Bile Acids and Salts
Digestion
Quality of service
Enzymes

Bile Acids as Potential Biomarkers to Assess Liver Impairment in Polycystic Kidney Disease

Brock, W. J., Beaudoin, J. J., Slizgi, J. R., Su, M., Jia, W., Roth, S. E. & Brouwer, K. L. R., Mar 1 2018, In : International Journal of Toxicology. 37, 2, p. 144-154 11 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Bile Acids and Salts
Quality of service
Biomarkers
Liver

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Evers, R., Piquette-Miller, M., Polli, J. W., Russel, F. G. M., Sprowl, J. A., Tohyama, K., Ware, J. A., de Wildt, S. N., Xie, W. & Brouwer, K. L. R., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Physiological Effects of Drugs
Pharmacokinetics
Inborn Genetic Diseases
Acute Disease
Chenodeoxycholic Acid
Taurocholic Acid
Bile Acids and Salts
Hepatocytes
Proteins