• 7962 Citations
  • 43 h-Index
1990 …2018
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  • 14 Similar Profiles
Chemical activation Chemical Compounds
rho GTP-Binding Proteins Medicine & Life Sciences
Type C Phospholipases Medicine & Life Sciences
Guanine Nucleotide Exchange Factors Medicine & Life Sciences
GTP Phosphohydrolases Chemical Compounds
Proteins Medicine & Life Sciences
Isoenzymes Medicine & Life Sciences
Guanine Nucleotides Medicine & Life Sciences

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Projects 1995 2018

Research Output 1990 2018

A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes

Huang, W., Wang, X., Endo-Streeter, S., Barrett, M., Waybright, J., Wohlfeld, C., Hajicek, N., Harden, T. K., Sondek, J. & Zhang, Q. Jan 1 2018 In : Journal of Biological Chemistry. 293, 5, p. 1728-1735 8 p.

Research output: Contribution to journalArticle

Isoenzymes
Disease control
Mammals
Type C Phospholipases
Cell membranes

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI

Cook, A. A., Deng, W., Ren, J., Li, R., Sondek, J. & Bergmeier, W. Jan 1 2018 In : Journal of Biological Chemistry. 293, 22, p. 8521-8529 9 p.

Research output: Contribution to journalArticle

EF Hand Motifs
Calcium
Platelets
Telegraph systems
Blood Platelets
13 Citations

TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis

Nishimura, M. T., Anderson, R. G., Cherkis, K. A., Law, T. F., Liu, Q. L., Machius, M., Nimchuk, Z. L., Yang, L., Chung, E. H., El Kasmi, F., Hyunh, M., Nishimura, E. O., Sondek, J. E. & Dangl, J. L. Mar 7 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 10, p. E2053-E2062

Research output: Contribution to journalArticle

Interleukin Receptors
Arabidopsis
Cell Death
Nucleotides
Plant Immunity
2 Citations

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

Ren, J., Cook, A. A., Bergmeier, W. & Sondek, J. May 20 2016 In : Biochemical and Biophysical Research Communications. 474, 1, p. 193-198 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Chemical activation
Feedback
Guanine Nucleotide Exchange Factors
Signal transduction
17 Citations

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

Lozano, M. L., Cook, A., Bastida, J. M., Paul, D. S., Iruin, G., Cid, A. R., Adan-Pedroso, R., González-Porras, J. R., Hernández-Rivas, J. M., Fletcher, S. J., Johnson, B., Morgan, N., Ferrer-Marin, F., Vicente, V., Sondek, J., Watson, S. P., Bergmeier, W. & Rivera, J. Sep 1 2016 In : Blood. 128, 9, p. 1282-1289 8 p.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
Blood Platelets
Chemical activation
Integrins