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  • 19 Similar Profiles
Proteins Medicine & Life Sciences
Chemical activation Chemical Compounds
Pleckstrin Homology Domains Medicine & Life Sciences
Type C Phospholipases Medicine & Life Sciences
rho GTP-Binding Proteins Medicine & Life Sciences
Isoenzymes Medicine & Life Sciences
GTP Phosphohydrolases Chemical Compounds
Guanine Nucleotide Exchange Factors Medicine & Life Sciences

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Projects 1995 2018

Research Output 1990 2017

10 Citations

TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis

Nishimura, M. T., Anderson, R. G., Cherkis, K. A., Law, T. F., Liu, Q. L., Machius, M., Nimchuk, Z. L., Yang, L., Chung, E. H., El Kasmi, F., Hyunh, M., Nishimura, E. O., Sondek, J. E. & Dangl, J. L. Mar 7 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 10, p. E2053-E2062

Research output: Research - peer-reviewArticle

Interleukin Receptors
Arabidopsis
Cell Death
Nucleotides
Proteins
1 Citations

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

Ren, J., Cook, A. A., Bergmeier, W. & Sondek, J. May 20 2016 In : Biochemical and Biophysical Research Communications. 474, 1, p. 193-198 6 p.

Research output: Research - peer-reviewArticle

Phosphorylation
Chemical activation
Feedback
Guanine Nucleotide Exchange Factors
Signal transduction
13 Citations

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

Lozano, M. L., Cook, A., Bastida, J. M., Paul, D. S., Iruin, G., Cid, A. R., Adan-Pedroso, R., González-Porras, J. R., Hernández-Rivas, J. M., Fletcher, S. J., Johnson, B., Morgan, N., Ferrer-Marin, F., Vicente, V., Sondek, J., Watson, S. P., Bergmeier, W. & Rivera, J. Sep 1 2016 In : Blood. 128, 9, p. 1282-1289 8 p.

Research output: Research - peer-reviewArticle

Platelet Activation
Blood Platelets
Mutation
Platelets
Chemical activation
6 Citations

The phospholipase C isozymes and their regulation

Gresset, A., Sondek, J. & Harden, T. K. 2015 In : Sub-Cellular Biochemistry. 58, p. 61-94 34 p.

Research output: Research - peer-reviewArticle

Type C Phospholipases
Isoenzymes
Chemical activation
Phospholipase C delta
Phospholipase C beta
7 Citations

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation

Schmitz, A. L. , Schrage, R. , Gaffal, E. , Charpentier, T. H. , Wiest, J. , Hiltensperger, G. , Morschel, J. , Hennen, S. , Häußler, D. , Horn, V. , Wenzel, D. , Grundmann, M. , Büllesbach, K. M. , Schröder, R. , Brewitz, H. H. , Schmidt, J. , Gomeza, J. , Galés, C. , Fleischmann, B. K. , Tüting, T. & 8 others Imhof, D., Tietze, D., Gütschow, M., Holzgrabe, U., Sondek, J., Harden, T. K., Mohr, K. & Kostenis, E. Jul 17 2014 In : Chemistry and Biology. 21, 7, p. 890-902 13 p.

Research output: Research - peer-reviewArticle

Conformations
Molecules
Proteins
Heterotrimeric GTP-Binding Proteins
G-Protein-Coupled Receptors