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  • 7 Similar Profiles
Protein-Tyrosine Kinases Medicine & Life Sciences
Epidermal Growth Factor Receptor Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Tyrosine Medicine & Life Sciences
Epidermal Growth Factor Medicine & Life Sciences
Receptor Protein-Tyrosine Kinases Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences

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Projects 1981 2018

Melanoma
Immunotherapy
Neoplasms
Immune System
axl receptor tyrosine kinase
Breast Neoplasms
Epidemiology
Population
Neoplasms
Receptor Protein-Tyrosine Kinases
Breast Neoplasms
Epidermal Growth Factor Receptor
Neoplasms
Genes

Research Output 1970 2018

1 Citations

MerTK as a therapeutic target in glioblastoma: Neuro Oncol

Wu, J., Frady, L. N., Bash, R. E., Cohen, S. M., Schorzman, A. N., Su, Y. T., Irvin, D. M., Zamboni, W. C., Wang, X., Frye, S. V., Ewend, M. G., Sulman, E. P., Gilbert, M. R., Earp, H. S. & Miller, C. R. Jun 13 2018 In : Neuro-Oncology. 20, 1, p. 92-102 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Macrophages
Neoplasms
Therapeutics
UNC2025
2 Citations

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors

McIver, A. L., Zhang, W., Liu, Q., Jiang, X., Stashko, M. A., Nichols, J., Miley, M. J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D. K., Earp, H. S., Kireev, D., Frye, S. V. & Wang, X. Jan 1 2017 In : ChemMedChem. 12, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

Pyrimidines
Protein-Tyrosine Kinases
Assays
Immunosorbents
Enzyme-Linked Immunosorbent Assay
17 Citations

Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex

Zawistowski, J. S. , Bevill, S. M. , Goulet, D. R. , Stuhlmiller, T. J. , Beltran, A. S. , Olivares-Quintero, J. F. , Singh, D. , Sciaky, N. , Parker, J. S. , Rashid, N. U. , Chen, X. , Duncan, J. S. , Whittle, M. C. , Angus, S. P. , Velarde, S. H. , Golitz, B. T. , He, X. , Santos, C. , Darr, D. B. , Gallagher, K. & 5 others Graves, L. M., Perou, C. M., Carey, L. A., Shelton Earp, H. & Johnson, G. L. Mar 1 2017 In : Cancer Discovery. 7, 3, p. 302-321 20 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Mitogen-Activated Protein Kinase Kinases
Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Neoplasms
6 Citations

UNC2025, a MERTK small-molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models

DeRyckere, D., Lee-Sherick, A. B., Huey, M. G., Hill, A. A., Tyner, J. W., Jacobsen, K. M., Page, L. S., Kirkpatrick, G. G., Eryildiz, F., Montgomery, S. A., Zhang, W., Wang, X., Frye, S. V., Earp, H. S. & Graham, D. K. Mar 15 2017 In : Clinical Cancer Research. 23, 6, p. 1481-1492 12 p.

Research output: Contribution to journalArticle

Methotrexate
Leukemia
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Heterografts
8 Citations

Germline analysis from tumor-germline sequencing dyads to identify clinically actionable secondary findings

Seifert, B. A., O'Daniel, J. M., Amin, K., Marchuk, D. S., Patel, N. M., Parker, J. S., Hoyle, A. P., Mose, L. E., Marron, A., Hayward, M. C., Bizon, C., Wilhelmsen, K. C., Evans, J. P., Earp, H. S., Sharpless, N. E., Hayes, D. N. & Berg, J. S. Aug 15 2016 In : Clinical Cancer Research. 22, 16, p. 4087-4094 8 p.

Research output: Contribution to journalArticle

Neoplasms
Neoplasm Genes
Genes
Research Design
Guidelines