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  • 12 Similar Profiles
Phosphorylation Medicine & Life Sciences
Protein-Tyrosine Kinases Medicine & Life Sciences
Epidermal Growth Factor Receptor Medicine & Life Sciences
Tyrosine Medicine & Life Sciences
Epidermal Growth Factor Medicine & Life Sciences
Liver Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences

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Projects 1981 2018

Neoplasms
axl receptor tyrosine kinase
Melanoma
Immunotherapy
Immune System
Breast Neoplasms
Epidemiology
Population
Neoplasms
Receptor Protein-Tyrosine Kinases
Breast Neoplasms
Neoplasms
Genes
Epidermal Growth Factor Receptor

Research Output 1970 2017

1 Citations

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors

McIver, A. L., Zhang, W., Liu, Q., Jiang, X., Stashko, M. A., Nichols, J., Miley, M. J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D. K., Earp, H. S., Kireev, D., Frye, S. V. & Wang, X. 2017 In : ChemMedChem. 12, 3, p. 207-213 7 p.

Research output: Research - peer-reviewArticle

Pyrimidines
Protein-Tyrosine Kinases
Assays
Immunosorbents
Enzymes
9 Citations

Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex

Zawistowski, J. S. , Bevill, S. M. , Goulet, D. R. , Stuhlmiller, T. J. , Beltran, A. S. , Olivares-Quintero, J. F. , Singh, D. , Sciaky, N. , Parker, J. S. , Rashid, N. U. , Chen, X. , Duncan, J. S. , Whittle, M. C. , Angus, S. P. , Velarde, S. H. , Golitz, B. T. , He, X. , Santos, C. , Darr, D. B. , Gallagher, K. & 5 others Graves, L. M., Perou, C. M., Carey, L. A., Shelton Earp, H. & Johnson, G. L. Mar 1 2017 In : Cancer Discovery. 7, 3, p. 302-321 20 p.

Research output: Research - peer-reviewArticle

Positive Transcriptional Elongation Factor B
Mitogen-Activated Protein Kinase Kinases
Neoplasms
Triple Negative Breast Neoplasms
trametinib
3 Citations

UNC2025, a MERTK small-molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models

DeRyckere, D., Lee-Sherick, A. B., Huey, M. G., Hill, A. A., Tyner, J. W., Jacobsen, K. M., Page, L. S., Kirkpatrick, G. G., Eryildiz, F., Montgomery, S. A., Zhang, W., Wang, X., Frye, S. V., Earp, H. S. & Graham, D. K. Mar 15 2017 In : Clinical Cancer Research. 23, 6, p. 1481-1492 12 p.

Research output: Research - peer-reviewArticle

Methotrexate
Leukemia
UNC2025
Acute Myeloid Leukemia
Therapeutics
6 Citations

Germline analysis from tumor-germline sequencing dyads to identify clinically actionable secondary findings

Seifert, B. A., O'Daniel, J. M., Amin, K., Marchuk, D. S., Patel, N. M., Parker, J. S., Hoyle, A. P., Mose, L. E., Marron, A., Hayward, M. C., Bizon, C., Wilhelmsen, K. C., Evans, J. P., Earp, H. S., Sharpless, N. E., Hayes, D. N. & Berg, J. S. Aug 15 2016 In : Clinical Cancer Research. 22, 16, p. 4087-4094 8 p.

Research output: Research - peer-reviewArticle

Neoplasms
Neoplasm Genes
Genes
Research Design
Guidelines
12 Citations

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

Lee-Sherick, A. B., Zhang, W., Menachof, K. K., Hill, A. A., Rinella, S., Kirkpatrick, G., Page, L. S., Stashko, M. A., Jordan, C. T., Wei, Q., Liu, J., Zhang, D., DeRyckere, D., Wang, X., Frye, S., Shelton Earp, H. & Graham, D. K. Jan 1 2015 In : Oncotarget. 6, 9, p. 6722-6736 15 p.

Research output: Research - peer-reviewArticle

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Therapeutics
UNC1666
Phosphorylation