Research Output 1977 2017

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2017
7 Citations

Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment

Vetreno, R. P., Yaxley, R., Paniagua, B., Johnson, G. A. & Crews, F. T. May 1 2017 In : Addiction Biology. 22, 3, p. 712-723 12 p.

Research output: Contribution to journalArticle

Ethanol
Young Adult
Magnetic Resonance Imaging
Prefrontal Cortex
Histology
7 Citations
Microglia
Innate Immunity
Neurons
Lipopolysaccharides
Poly I-C
9 Citations

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7

Coleman, L. G., Zou, J. & Crews, F. T. Jan 25 2017 In : Journal of Neuroinflammation. 14, 1, 22

Research output: Contribution to journalArticle

MicroRNAs
Ethanol
Entorhinal Cortex
Toll-Like Receptors
Microglia
2016
20 Citations

A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood

Sakharkar, A. J., Vetreno, R. P., Zhang, H., Kokare, D. M., Crews, F. T. & Pandey, S. C. Dec 1 2016 In : Brain Structure and Function. 221, 9, p. 4691-4703 13 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Neurogenesis
Acetylation
Histones
Alcohols
12 Citations
Diffusion Tensor Imaging
Ethanol
Cerebellum
Neocortex
Corpus Callosum
2 Citations

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis

Odena, G., Chen, J., Lozano, J. J., Altamirano, J., Rodrigo-Torres, D., Affo, S., Morales-Ibanez, O., Matsushita, H., Zou, J., Dumitru, R., Caballeria, J., Gines, P., Arroyo, V., You, M., Rautou, P. E., Valla, D., Crews, F., Seki, E., Sancho-Bru, P. & Bataller, R. Oct 18 2016 In : Scientific Reports. 6, 35610

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Lipopolysaccharides
Keratins
Collagen
Alcoholic Liver Diseases
2015
8 Citations

Adolescent intermittent alcohol exposure: Deficits in object recognition memory and forebrain cholinergic markers

Swartzwelder, H. S., Acheson, S. K., Miller, K. M., Sexton, H. G., Liu, W., Crews, F. T. & Risher, M. L. Nov 3 2015 In : PLoS ONE. 10, 11, e0140042

Research output: Contribution to journalArticle

cholinergic agents
Object recognition
Prosencephalon
Cholinergic Agents
alcohols
17 Citations
Nucleus Accumbens
Prefrontal Cortex
Binge Drinking
Ethanol
Brain
17 Citations
Cholinergic Neurons
Dopaminergic Neurons
Ethanol
Choline O-Acetyltransferase
Reward
33 Citations
Neurogenesis
Hippocampus
Ethanol
Dentate Gyrus
Parahippocampal Gyrus
13 Citations

Brain pathways to recovery from alcohol dependence

Cui, C. , Noronha, A. , Warren, K. R. , Koob, G. F. , Sinha, R. , Thakkar, M. , Matochik, J. , Crews, F. T. , Chandler, L. J. , Pfefferbaum, A. , Becker, H. C. , Lovinger, D. , Everitt, B. J. , Egli, M. , Mandyam, C. D. , Fein, G. , Potenza, M. N. , Harris, R. A. , Grant, K. A. , Roberto, M. & 2 others Meyerhoff, D. J. & Sullivan, E. V. Jan 1 2015 In : Alcohol. 49, 5, p. 435-452 18 p.

Research output: Contribution to journalArticle

Alcoholism
Brain
brain
alcohol
Alcohols
2014
23 Citations

Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain

Vetreno, R. P., Broadwater, M., Liu, W., Spear, L. P. & Crews, F. T. Nov 18 2014 In : PLoS ONE. 9, 11, e113421

Research output: Contribution to journalArticle

choline acetyltransferase
Choline O-Acetyltransferase
Neurons
Brain
Ethanol
37 Citations
Extracellular Matrix Proteins
Brain
Ethanol
Therapeutics
Reversal Learning
14 Citations

Current hypotheses on the mechanisms of alcoholism

Vetreno, R. P. & Crews, F. T. Jan 1 2014 In : Handbook of Clinical Neurology. 125, p. 477-497 21 p.

Research output: Contribution to journalArticle

Alcoholism
Executive Function
CREB-Binding Protein
Limbic System
Impulsive Behavior
13 Citations
Monocarboxylic Acid Transporters
Thiamine Deficiency
Thiamine
Thalamus
Acetate-CoA Ligase
33 Citations

Neuroimmune basis of alcoholic brain damage

Crews, F. T. & Vetreno, R. P. Jan 1 2014 In : International Review of Neurobiology. 118, p. 315-357 43 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Brain
Alcoholism
Oxidative Stress
Ethanol
30 Citations

Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure

Broadwater, M. A., Liu, W., Crews, F. T. & Spear, L. P. Jan 1 2014 In : Developmental Neuroscience. 36, 3-4, p. 297-305 9 p.

Research output: Contribution to journalArticle

Neurogenesis
Cell Death
Ethanol
Dentate Gyrus
Lateral Ventricles
65 Citations

Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling

Zou, J. Y. & Crews, F. T. Feb 14 2014 In : PLoS ONE. 9, 2, e87915

Research output: Contribution to journalArticle

Histone Deacetylases
histones
Brain
Ethanol
ethanol
2013
12 Citations

Comparison of Magnetic Resonance Imaging in Live vs. Post Mortem Rat Brains

Oguz, I., Yaxley, R., Budin, F., Hoogstoel, M., Lee, J., Maltbie, E., Liu, W. & Crews, F. T. Aug 13 2013 In : PLoS ONE. 8, 8, e71027

Research output: Contribution to journalArticle

magnetic resonance imaging
Rats
Brain
Magnetic Resonance Imaging
brain
83 Citations

High mobility group box 1/toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence

Crews, F. T., Qin, L., Sheedy, D., Vetreno, R. P. & Zou, J. Apr 1 2013 In : Biological Psychiatry. 73, 7, p. 602-612 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 1
Alcoholism
Ethanol
Brain
Cytokines
52 Citations
Prefrontal Cortex
Ethanol
Alcoholism
Drinking
Age of Onset
91 Citations

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

Qin, L., Liu, Y., Hong, J. S. & Crews, F. T. Jun 2013 In : GLIA. 61, 6, p. 855-868 14 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Substantia Nigra
Reactive Oxygen Species
Microglia
27 Citations

Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood

Ehlers, C. L., Liu, W., Wills, D. N. & Crews, F. T. Aug 6 2013 In : Neuroscience. 244, p. 1-15 15 p.

Research output: Contribution to journalArticle

Neurogenesis
Ethanol
Locomotion
Uridine
Caspase 3
15 Citations

Peri-adolescent ethanol vapor exposure produces reductions in hippocampal volume that are correlated with deficits in prepulse inhibition of the startle

Ehlers, C. L., Oguz, I., Budin, F., Wills, D. N. & Crews, F. T. Sep 2013 In : Alcoholism: Clinical and Experimental Research. 37, 9, p. 1466-1475 10 p.

Research output: Contribution to journalArticle

Animals
Ethanol
Vapors
Diffusion tensor imaging
Diffusion Tensor Imaging
31 Citations
Corticotropin-Releasing Hormone
Brain
Ethanol
Cytokines
Messenger RNA
2012
61 Citations
Toll-Like Receptor 1
Binge Drinking
Prefrontal Cortex
Reversal Learning
Ethanol
34 Citations

ATP-P2X 7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation

Zou, J., Vetreno, R. P. & Crews, F. T. Apr 1 2012 In : GLIA. 60, 4, p. 661-673 13 p.

Research output: Contribution to journalArticle

Neuroglia
Adenosine Triphosphate
Cell Proliferation
Deoxyuridine
Aquaporin 4
67 Citations
Toll-Like Receptor 3
Poly I-C
Ethanol
Brain
Cytokines
54 Citations

Inflammasome-IL-1β signaling mediates ethanol inhibition of hippocampal neurogenesis

Zou, J. & Crews, F. T. Jun 18 2012 In : Frontiers in Neuroscience. MAY, Article 77

Research output: Contribution to journalArticle

Inflammasomes
Neurogenesis
Ethanol
Alcoholics
Astrocytes
111 Citations
NADPH Oxidase
Reactive Oxygen Species
Ethanol
Alcohols
Prefrontal Cortex
25 Citations

Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis

Coleman, L. G., Oguz, I., Lee, J., Styner, M. & Crews, F. T. Sep 1 2012 In : Alcohol. 46, 6, p. 603-612 10 p.

Research output: Contribution to journalArticle

Neurogenesis
Neurons
Brain
brain
Ethanol
2011
81 Citations
Binge Drinking
Neurochemistry
Gene expression
Neurotransmitter Agents
Brain
49 Citations

Associations Between Heavy Drinking and Changes in Impulsive Behavior Among Adolescent Boys

White, H. R., Marmorstein, N. R., Crews, F. T., Bates, M. E., Mun, E. Y. & Loeber, R. Feb 1 2011 In : Alcoholism: Clinical and Experimental Research. 35, 2, p. 295-303 9 p.

Research output: Contribution to journalArticle

Impulsive Behavior
Drinking
Trajectories
Alcohols
Brain
20 Citations

Chronically implanted, nafion-coated Ag/AgCl reference electrodes for neurochemical applications

Hashemi, P., Walsh, P. L., Guillot, T. S., Gras-Najjar, J., Takmakov, P., Crews, F. T. & Wightman, R. M. Nov 16 2011 In : ACS Chemical Neuroscience. 2, 11, p. 658-666 9 p.

Research output: Contribution to journalArticle

Electrodes
Dopamine
Encapsulation
Neuroglia
perfluorosulfonic acid
18 Citations

Immune function genes, genetics, and the neurobiology of addiction

Crews, F. T. 2011 In : Alcohol Research and Health. 34, 3, p. 355-361 7 p.

Research output: Contribution to journalArticle

Neurobiology
Alcoholism
Genes
Innate Immunity
Immune System
27 Citations

Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: Correlation with behavioral pathology

Ehlers, C. L., Criado, J. R., Wills, D. N., Liu, W. & Crews, F. T. Dec 29 2011 In : Neuroscience. 199, p. 333-345 13 p.

Research output: Contribution to journalArticle

Choline O-Acetyltransferase
Prosencephalon
Ethanol
Alcohols
Pathology
19 Citations

Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation

Liu, Y., Lo, Y. C., Qian, L., Crews, F. T., Wilson, B., Chen, H. L., Wu, H. M., Chen, S. H., Wei, K., Lu, R. B., Ali, S. & Hong, J. S. Feb 1 2011 In : Neuropharmacology. 60, 2-3, p. 373-380 8 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Verapamil
Anti-Inflammatory Agents
Calcium Channels
Neurons
2010
79 Citations
Gene expression
Brain
Ethanol
Cytokines
Gene Expression
42 Citations

Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats

Hansson, A. C., Nixon, K., Rimondini, R., Damadzic, R., Sommer, W. H., Eskay, R., Crews, F. T. & Heilig, M. Jun 2010 In : International Journal of Neuropsychopharmacology. 13, 5, p. 583-593 11 p.

Research output: Contribution to journalArticle

Neurogenesis
Prosencephalon
Alcoholism
Stem Cells
Lateral Ventricles
2009
69 Citations

Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice

Stevenson, J. R., Schroeder, J. P., Nixon, K., Besheer, J., Crews, F. T. & Hodge, C. W. Apr 1 2009 In : Neuropsychopharmacology. 34, 5, p. 1209-1222 14 p.

Research output: Contribution to journalArticle

Neurogenesis
Alcohol Drinking
Depression
Alcohol Abstinence
Antidepressive Agents
20 Citations
Alcohol Abstinence
Self Administration
Cell proliferation
Bromodeoxyuridine
Rats
2 Citations

Alcohol-related neurodegeneration and recovery

Crews, F. T. 2009 In : Alcohol Research and Health. 31, 4, p. 377-388 12 p.

Research output: Contribution to journalArticle

Alcohols
Neurogenesis
Brain
Alcoholics
Drinking
24 Citations
Dizocilpine Maleate
Prefrontal Cortex
Aspartic Acid
Neurons
Impulsive Behavior
2008
35 Citations

1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in rats

Nicholas, P. C., Kim, D., Crews, F. T. & Macdonald, J. M. Feb 2008 In : Chemical Research in Toxicology. 21, 2, p. 408-420 13 p.

Research output: Contribution to journalArticle

Metabolomics
Liver
Rats
Brain
Ethanol
65 Citations

Distinct cell proliferation events during abstinence after alcohol dependence: Microglia proliferation precedes neurogenesis

Nixon, K., Kim, D. H., Potts, E. N., He, J. & Crews, F. T. Aug 1 2008 In : Neurobiology of Disease. 31, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

Neurogenesis
Microglia
Alcoholism
Alcohols
Cell Proliferation
36 Citations

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

Liu, Y., Qin, L., Wilson, B., Wu, X., Qian, L., Granholm, A. C., Crews, F. T. & Hong, J. S. Sep 1 2008 In : NeuroToxicology. 29, 5, p. 864-870 7 p.

Research output: Contribution to journalArticle

Substantia Nigra
Endotoxins
Neurons
Injections
Sex Characteristics
218 Citations

Increased MCP-1 and microglia in various regions of the human alcoholic brain

He, J. & Crews, F. T. Apr 1 2008 In : Experimental Neurology. 210, 2, p. 349-358 10 p.

Research output: Contribution to journalArticle

Microglia
Brain
Calcium-Binding Proteins
Cytokines
Ventral Tegmental Area
241 Citations

Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

Qin, L., He, J., Hanes, R. N., Pluzarev, O., Hong, J. S. & Crews, F. T. Mar 18 2008 In : Journal of Neuroinflammation. 5, 10

Research output: Contribution to journalArticle

Endotoxins
Ethanol
Cytokines
Brain
Lipopolysaccharides
2007
91 Citations

Neurogenesis decreases during brain maturation from adolescence to adulthood

He, J. & Crews, F. T. Feb 1 2007 In : Pharmacology Biochemistry and Behavior. 86, 2, p. 327-333 7 p.

Research output: Contribution to journalArticle

Neurogenesis
Somatomedins
Bromodeoxyuridine
Insulin-Like Growth Factor Binding Protein 1
Brain
904 Citations

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J. S., Knapp, D. J. & Crews, F. T. Apr 1 2007 In : GLIA. 55, 5, p. 453-462 10 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type II
Brain
Microglia
Substantia Nigra
Inflammation