Research Output 1977 2017

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2017
3 Citations

Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment

Vetreno, R. P., Yaxley, R., Paniagua, B., Johnson, G. A. & Crews, F. T. May 1 2017 In : Addiction Biology. 22, 3, p. 712-723 12 p.

Research output: Research - peer-reviewArticle

Ethanol
Therapeutics
Young Adult
Magnetic Resonance Imaging
Brain
4 Citations
Microglia
Innate Immunity
Lipopolysaccharides
Ethanol
Neurons
6 Citations

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7

Coleman, L. G., Zou, J. & Crews, F. T. Jan 25 2017 In : Journal of Neuroinflammation. 14, 1, 22

Research output: Research - peer-reviewArticle

MicroRNAs
Ethanol
Entorhinal Cortex
Toll-Like Receptors
Microglia
2016
15 Citations

A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood

Sakharkar, A. J., Vetreno, R. P., Zhang, H., Kokare, D. M., Crews, F. T. & Pandey, S. C. Mar 3 2016 (Accepted/In press) In : Brain Structure and Function. p. 1-13 13 p.

Research output: Research - peer-reviewArticle

Brain-Derived Neurotrophic Factor
Neurogenesis
Acetylation
Histones
Alcohols
8 Citations
Diffusion Tensor Imaging
Ethanol
Brain
Cerebellum
Neocortex
2 Citations

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis

Odena, G., Chen, J., Lozano, J. J., Altamirano, J., Rodrigo-Torres, D., Affo, S., Morales-Ibanez, O., Matsushita, H., Zou, J., Dumitru, R., Caballeria, J., Gines, P., Arroyo, V., You, M., Rautou, P. E., Valla, D., Crews, F., Seki, E., Sancho-Bru, P. & Bataller, R. Oct 18 2016 In : Scientific Reports. 6, 35610

Research output: Research - peer-reviewArticle

Alcoholic Hepatitis
Lipopolysaccharides
Keratins
Collagen
Liver
2015
6 Citations

Adolescent intermittent alcohol exposure: Deficits in object recognition memory and forebrain cholinergic markers

Swartzwelder, H. S., Acheson, S. K., Miller, K. M., Sexton, H. G., Liu, W., Crews, F. T. & Risher, M. L. Nov 3 2015 In : PLoS ONE. 10, 11, e0140042

Research output: Research - peer-reviewArticle

Prosencephalon
Cholinergic Agents
Alcohols
Recognition (Psychology)
cholinergic agents
12 Citations
Nucleus Accumbens
Prefrontal Cortex
Ethanol
Brain
Binge Drinking
13 Citations
Cholinergic Neurons
Dopaminergic Neurons
Ethanol
Choline O-Acetyltransferase
Reward
27 Citations
Neurogenesis
Hippocampus
Ethanol
Dentate Gyrus
Therapeutics
12 Citations

Brain pathways to recovery from alcohol dependence

Cui, C. , Noronha, A. , Warren, K. R. , Koob, G. F. , Sinha, R. , Thakkar, M. , Matochik, J. , Crews, F. T. , Chandler, L. J. , Pfefferbaum, A. , Becker, H. C. , Lovinger, D. , Everitt, B. J. , Egli, M. , Mandyam, C. D. , Fein, G. , Potenza, M. N. , Harris, R. A. , Grant, K. A. , Roberto, M. & 2 others Meyerhoff, D. J. & Sullivan, E. V. Jan 1 2015 In : Alcohol. 49, 5, p. 435-452 18 p.

Research output: Research - peer-reviewArticle

Alcoholism
Brain
Research
brain
alcohol
2014
20 Citations

Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain

Vetreno, R. P., Broadwater, M., Liu, W., Spear, L. P. & Crews, F. T. Nov 18 2014 In : PLoS One. 9, 11, e113421

Research output: Research - peer-reviewArticle

Choline O-Acetyltransferase
Ethanol
Neurons
Brain
choline acetyltransferase
31 Citations
Extracellular Matrix Proteins
Ethanol
Brain
Therapeutics
Imaging techniques
14 Citations

Current hypotheses on the mechanisms of alcoholism

Vetreno, R. P. & Crews, F. T. Jan 1 2014 In : Handbook of Clinical Neurology. 125, p. 477-497 21 p.

Research output: Research - peer-reviewArticle

Alcoholism
Executive Function
CREB-Binding Protein
Limbic System
Impulsive Behavior
12 Citations
Monocarboxylic Acid Transporters
Thiamine
Acetates
Ethanol
Genes
31 Citations

Neuroimmune basis of alcoholic brain damage

Crews, F. T. & Vetreno, R. P. Jan 1 2014 In : International Review of Neurobiology. 118, p. 315-357 43 p.

Research output: Research - peer-reviewArticle

Brain
Genes
HMGB1 Protein
Alcoholism
Oxidative Stress
25 Citations

Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure

Broadwater, M. A., Liu, W., Crews, F. T. & Spear, L. P. Jan 1 2014 In : Developmental Neuroscience. 36, 3-4, p. 297-305 9 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Cell Death
Ethanol
Dentate Gyrus
Lateral Ventricles
58 Citations

Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling

Zou, J. Y. & Crews, F. T. Feb 14 2014 In : PLoS One. 9, 2, e87915

Research output: Research - peer-reviewArticle

histones
ethanol
brain
Histone Deacetylases
Brain
2013
12 Citations

Comparison of Magnetic Resonance Imaging in Live vs. Post Mortem Rat Brains

Oguz, I., Yaxley, R., Budin, F., Hoogstoel, M., Lee, J., Maltbie, E., Liu, W. & Crews, F. T. Aug 13 2013 In : PLoS One. 8, 8, e71027

Research output: Research - peer-reviewArticle

Rats
Brain
Magnetic Resonance Imaging
magnetic resonance imaging
brain
81 Citations

High mobility group box 1/toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence

Crews, F. T., Qin, L., Sheedy, D., Vetreno, R. P. & Zou, J. Apr 1 2013 In : Biological Psychiatry. 73, 7, p. 602-612 11 p.

Research output: Research - peer-reviewArticle

Toll-Like Receptor 1
Alcoholism
Brain
Ethanol
Cytokines
47 Citations
Prefrontal Cortex
Advanced Glycosylation End Product-Specific Receptor
Underage Drinking
Ethanol
Alcoholism
87 Citations

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

Qin, L., Liu, Y., Hong, J. S. & Crews, F. T. Jun 2013 In : GLIA. 61, 6, p. 855-868 14 p.

Research output: Research - peer-reviewArticle

NADPH Oxidase
Oxidative Stress
Substantia Nigra
Reactive Oxygen Species
Microglia
23 Citations

Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood

Ehlers, C. L., Liu, W., Wills, D. N. & Crews, F. T. Aug 6 2013 In : Neuroscience. 244, p. 1-15 15 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Ethanol
Conflict (Psychology)
Locomotion
Uridine
14 Citations

Peri-adolescent ethanol vapor exposure produces reductions in hippocampal volume that are correlated with deficits in prepulse inhibition of the startle

Ehlers, C. L., Oguz, I., Budin, F., Wills, D. N. & Crews, F. T. Sep 2013 In : Alcoholism: Clinical and Experimental Research. 37, 9, p. 1466-1475 10 p.

Research output: Research - peer-reviewArticle

Ethanol
Prepulse Inhibition
Animals
Vapors
Diffusion Tensor Imaging
29 Citations
Corticotropin-Releasing Hormone
Brain
Ethanol
Cytokines
Messenger RNA
2012
58 Citations
Toll-Like Receptor 1
Binge Drinking
Prefrontal Cortex
Underage Drinking
Ethanol
32 Citations

ATP-P2X 7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation

Zou, J., Vetreno, R. P. & Crews, F. T. Apr 1 2012 In : GLIA. 60, 4, p. 661-673 13 p.

Research output: Research - peer-reviewArticle

Neuroglia
Adenosine Triphosphate
Cell Proliferation
Deoxyuridine
Aquaporin 4
63 Citations
Toll-Like Receptor 3
Ethanol
Brain
Poly I-C
Cytokines
51 Citations

Inflammasome-IL-1β signaling mediates ethanol inhibition of hippocampal neurogenesis

Zou, J. & Crews, F. T. Jun 18 2012 In : Frontiers in Neuroscience. MAY, Article 77

Research output: Research - peer-reviewArticle

Inflammasomes
Neurogenesis
Ethanol
Inhibition (Psychology)
Alcoholics
106 Citations
NADPH Oxidase
Reactive Oxygen Species
Ethanol
Alcohols
Brain
23 Citations

Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis

Coleman, L. G., Oguz, I., Lee, J., Styner, M. & Crews, F. T. Sep 1 2012 In : Alcohol. 46, 6, p. 603-612 10 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Ethanol
Neurons
Brain
Therapeutics
2011
75 Citations
Binge Drinking
Neurochemistry
Neurotransmitter Agents
Gene Expression
Brain
48 Citations

Associations Between Heavy Drinking and Changes in Impulsive Behavior Among Adolescent Boys

White, H. R., Marmorstein, N. R., Crews, F. T., Bates, M. E., Mun, E. Y. & Loeber, R. Feb 1 2011 In : Alcoholism: Clinical and Experimental Research. 35, 2, p. 295-303 9 p.

Research output: Research - peer-reviewArticle

Impulsive Behavior
Drinking
Trajectories
Alcohols
Blood Alcohol Content
18 Citations

Chronically implanted, nafion-coated Ag/AgCl reference electrodes for neurochemical applications

Hashemi, P., Walsh, P. L., Guillot, T. S., Gras-Najjar, J., Takmakov, P., Crews, F. T. & Wightman, R. M. Nov 16 2011 In : ACS Chemical Neuroscience. 2, 11, p. 658-666 9 p.

Research output: Research - peer-reviewArticle

Electrodes
perfluorosulfonic acid
Dopamine
Encapsulation
Neuroglia
18 Citations

Immune function genes, genetics, and the neurobiology of addiction

Crews, F. T. 2011 In : Alcohol Research and Health. 34, 3, p. 355-361 7 p.

Research output: Research - peer-reviewArticle

Neurobiology
Genes
Alcoholism
Innate Immunity
Immune System
24 Citations

Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: Correlation with behavioral pathology

Ehlers, C. L., Criado, J. R., Wills, D. N., Liu, W. & Crews, F. T. Dec 29 2011 In : Neuroscience. 199, p. 333-345 13 p.

Research output: Research - peer-reviewArticle

Choline O-Acetyltransferase
Prosencephalon
Ethanol
Alcohols
Pathology
17 Citations

Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation

Liu, Y., Lo, Y. C., Qian, L., Crews, F. T., Wilson, B., Chen, H. L., Wu, H. M., Chen, S. H., Wei, K., Lu, R. B., Ali, S. & Hong, J. S. Feb 1 2011 In : Neuropharmacology. 60, 2-3, p. 373-380 8 p.

Research output: Research - peer-reviewArticle

Dopaminergic Neurons
Verapamil
Anti-Inflammatory Agents
Calcium Channels
Neurons
2010
74 Citations
Ethanol
Cytokines
Gene Expression
Brain
Gene expression
40 Citations

Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats

Hansson, A. C., Nixon, K., Rimondini, R., Damadzic, R., Sommer, W. H., Eskay, R., Crews, F. T. & Heilig, M. Jun 2010 In : International Journal of Neuropsychopharmacology. 13, 5, p. 583-593 11 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Prosencephalon
Alcoholism
Stem Cells
Alcohols
2009
67 Citations

Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice

Stevenson, J. R., Schroeder, J. P., Nixon, K., Besheer, J., Crews, F. T. & Hodge, C. W. Apr 1 2009 In : Neuropsychopharmacology. 34, 5, p. 1209-1222 14 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Alcohol Drinking
Depression
Alcohol Abstinence
Antidepressive Agents
17 Citations
Alcohol Abstinence
Self Administration
Bromodeoxyuridine
Cell Differentiation
Stem Cells
2 Citations

Alcohol-related neurodegeneration and recovery

Crews, F. T. 2009 In : Alcohol Research and Health. 31, 4, p. 377-388 12 p.

Research output: Research - peer-reviewArticle

Alcohols
Brain
Neurogenesis
Alcoholics
Drinking
24 Citations
Prefrontal Cortex
Aspartic Acid
Neurons
Therapeutics
Dizocilpine Maleate
2008
35 Citations

1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in rats

Nicholas, P. C., Kim, D., Crews, F. T. & Macdonald, J. M. Feb 2008 In : Chemical Research in Toxicology. 21, 2, p. 408-420 13 p.

Research output: Research - peer-reviewArticle

Liver
Rats
Brain
Ethanol
Nuclear magnetic resonance
62 Citations

Distinct cell proliferation events during abstinence after alcohol dependence: Microglia proliferation precedes neurogenesis

Nixon, K., Kim, D. H., Potts, E. N., He, J. & Crews, F. T. Aug 1 2008 In : Neurobiology of Disease. 31, 2, p. 218-229 12 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Microglia
Alcoholism
Alcohols
Cell Proliferation
33 Citations

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

Liu, Y., Qin, L., Wilson, B., Wu, X., Qian, L., Granholm, A. C., Crews, F. T. & Hong, J. S. Sep 1 2008 In : NeuroToxicology. 29, 5, p. 864-870 7 p.

Research output: Research - peer-reviewArticle

Substantia Nigra
Endotoxins
Neurons
Injections
Sex Characteristics
209 Citations

Increased MCP-1 and microglia in various regions of the human alcoholic brain

He, J. & Crews, F. T. Apr 1 2008 In : Experimental Neurology. 210, 2, p. 349-358 10 p.

Research output: Research - peer-reviewArticle

Microglia
Brain
Cytokines
Calcium-Binding Proteins
Alcohols
228 Citations

Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

Qin, L., He, J., Hanes, R. N., Pluzarev, O., Hong, J. S. & Crews, F. T. Mar 18 2008 In : Journal of Neuroinflammation. 5, 10

Research output: Research - peer-reviewArticle

Endotoxins
Ethanol
Cytokines
Brain
Therapeutics
2007
88 Citations

Neurogenesis decreases during brain maturation from adolescence to adulthood

He, J. & Crews, F. T. Feb 1 2007 In : Pharmacology Biochemistry and Behavior. 86, 2, p. 327-333 7 p.

Research output: Research - peer-reviewArticle

Somatomedins
Bromodeoxyuridine
Brain
Neurogenesis
Insulin-Like Growth Factor Binding Protein 1
860 Citations

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J. S., Knapp, D. J. & Crews, F. T. Apr 1 2007 In : GLIA. 55, 5, p. 453-462 10 p.

Research output: Research - peer-reviewArticle

Brain
Inflammation
Receptors, Tumor Necrosis Factor, Type II
Microglia
Substantia Nigra