• 12957 Citations
  • 62 h-Index
1977 …2020
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Research Output 1977 2018

2018
1 Citations

Acute Ethanol Inhibition of Adult Hippocampal Neurogenesis Involves CB1 Cannabinoid Receptor Signaling

Khatri, D., Laroche, G., Grant, M. L., Jones, V. M., Vetreno, R. P., Crews, F. T. & Mukhopadhyay, S., Apr 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 4, p. 718-726 9 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Cannabinoid Receptors
Cannabinoids
Ethanol
Alcohols
3 Citations

Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood

Broadwater, M. A., Lee, S. H., Yu, Y., Zhu, H., Crews, F. T., Robinson, D. L. & Shih, Y-Y. I., Mar 1 2018, In : Addiction Biology. 23, 2, p. 810-823 14 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Alcohols
Nucleus Accumbens
Ethanol
Putamen
Cholinergic Neurons
indomethacin
cholinergic agents
Indomethacin
Cholinergic Agents

HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury

Coleman, L. G., Maile, R., Jones, S. W., Cairns, B. A. & Crews, F. T., Mar 1 2018, In : PloS one. 13, 3, e0195335.

Research output: Contribution to journalArticle

burns (injuries)
HMGB1 Protein
immune response
Wounds and Injuries
mice
2 Citations

HMGB1/IL-1β complexes regulate neuroimmune responses in alcoholism

Coleman, L. G., Zou, J., Qin, L. & Crews, F. T., Aug 1 2018, In : Brain, Behavior, and Immunity. 72, p. 61-77 17 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Alcoholism
Ethanol
Brain
Pathology

Innate Immune Signaling and Alcohol Use Disorders

Coleman, L. G. & Crews, F. T., Jan 1 2018, In : Handbook of experimental pharmacology. 248, p. 369-396 28 p.

Research output: Contribution to journalArticle

Pathology
Alcohols
Chemical activation
Rodentia
Brain
2 Citations
Neurogenesis
Indomethacin
Anti-Inflammatory Agents
Ethanol
Exercise

Stress and Alcohol Priming of Brain Toll-Like Receptor Signaling in Alcohol Use Disorder

Crews, F. T. & Vetreno, R. P., Nov 1 2018, In : Alcohol and alcoholism (Oxford, Oxfordshire). 53, 6, p. 639-641 3 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Brain
Alcohols

TLR7-let-7 Signaling Contributes to Ethanol-Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis

Massey, V. L., Qin, L., Cabezas, J., Caballeria, J., Sancho-Bru, P., Bataller, R. & Crews, F. T., Nov 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 11, p. 2107-2122 16 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Alcoholic Hepatitis
MicroRNAs
Ethanol
Liver
2017
4 Citations

Adolescent intermittent ethanol reduces serotonin expression in the adult raphe nucleus and upregulates innate immune expression that is prevented by exercise

Vetreno, R. P., Patel, Y., Patel, U., Walter, T. J. & Crews, F. T., Feb 1 2017, In : Brain, Behavior, and Immunity. 60, p. 333-345 13 p.

Research output: Contribution to journalArticle

Raphe Nuclei
Serotonin
Ethanol
Up-Regulation
Exercise
14 Citations

Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment

Vetreno, R. P., Yaxley, R., Paniagua, B., Johnson, G. A. & Crews, F. T., May 1 2017, In : Addiction Biology. 22, 3, p. 712-723 12 p.

Research output: Contribution to journalArticle

Ethanol
Young Adult
Magnetic Resonance Imaging
Prefrontal Cortex
Histology
1 Citations

Alcohol and Stress Activation of Microglia and Neurons: Brain Regional Effects

Walter, T. J., Vetreno, R. P. & Crews, F. T., Dec 1 2017, In : Alcoholism: Clinical and Experimental Research. 41, 12, p. 2066-2081 16 p.

Research output: Contribution to journalArticle

Microglia
Endotoxins
Neurons
Brain
Chemical activation
9 Citations
Microglia
Innate Immunity
Neurons
Lipopolysaccharides
Poly I-C
16 Citations

Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal

Walter, T. J. & Crews, F. T., Apr 20 2017, In : Journal of Neuroinflammation. 14, 1, 86.

Research output: Contribution to journalArticle

Ethanol
Brain
Microglia
Gene Expression
Genes
14 Citations

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7

Coleman, L. G., Zou, J. & Crews, F. T., Jan 25 2017, In : Journal of Neuroinflammation. 14, 1, 22.

Research output: Contribution to journalArticle

MicroRNAs
Ethanol
Entorhinal Cortex
Toll-Like Receptors
Microglia
5 Citations
Neurogenesis
Ethanol
Dentate Gyrus
Lateral Ventricles
Bromodeoxyuridine
2016
40 Citations

Adolescent alcohol exposure persistently impacts adult neurobiology and behavior

Crews, F. T., Vetreno, R. P., Broadwater, M. A. & Robinson, D. L., Oct 1 2016, In : Pharmacological reviews. 68, 4, p. 1074-1109 36 p.

Research output: Contribution to journalReview article

Neurobiology
Alcohols
Binge Drinking
Ethanol
Adolescent Behavior
29 Citations

A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood

Sakharkar, A. J., Vetreno, R. P., Zhang, H., Kokare, D. M., Crews, F. T. & Pandey, S. C., Dec 1 2016, In : Brain Structure and Function. 221, 9, p. 4691-4703 13 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Neurogenesis
Acetylation
Histones
Alcohols
17 Citations
Diffusion Tensor Imaging
Ethanol
Cerebellum
Neocortex
Corpus Callosum
6 Citations

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis

Odena, G., Chen, J., Lozano, J. J., Altamirano, J., Rodrigo-Torres, D., Affo, S., Morales-Ibanez, O., Matsushita, H., Zou, J., Dumitru, R., Caballeria, J., Gines, P., Arroyo, V., You, M., Rautou, P. E., Valla, D., Crews, F., Seki, E., Sancho-Bru, P. & Bataller, R., Oct 18 2016, In : Scientific Reports. 6, 35610.

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Lipopolysaccharides
Keratins
Collagen
Alcoholic Liver Diseases
50 Citations

Mechanisms of neuroimmune gene induction in alcoholism

Crews, F. T. & Vetreno, R. P., May 1 2016, In : Psychopharmacology. 233, 9, p. 1543-1557 15 p.

Research output: Contribution to journalReview article

Neuroimmunomodulation
Alcoholism
Brain
Alcohols
Genes
2015
11 Citations

Adolescent intermittent alcohol exposure: Deficits in object recognition memory and forebrain cholinergic markers

Swartzwelder, H. S., Acheson, S. K., Miller, K. M., Sexton, H. G., Liu, W., Crews, F. T. & Risher, M. L., Nov 3 2015, In : PloS one. 10, 11, e0140042.

Research output: Contribution to journalArticle

cholinergic agents
Object recognition
Prosencephalon
Cholinergic Agents
alcohols
19 Citations
Nucleus Accumbens
Prefrontal Cortex
Binge Drinking
Ethanol
Brain
28 Citations
Cholinergic Neurons
Dopaminergic Neurons
Ethanol
Choline O-Acetyltransferase
Reward
43 Citations
Neurogenesis
Hippocampus
Ethanol
Dentate Gyrus
Parahippocampal Gyrus
16 Citations

Brain pathways to recovery from alcohol dependence

Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M., Matochik, J., Crews, F. T., Chandler, L. J., Pfefferbaum, A., Becker, H. C., Lovinger, D., Everitt, B. J., Egli, M., Mandyam, C. D., Fein, G., Potenza, M. N., Harris, R. A., Grant, K. A., Roberto, M. & 2 othersMeyerhoff, D. J. & Sullivan, E. V., Jan 1 2015, In : Alcohol. 49, 5, p. 435-452 18 p.

Research output: Contribution to journalArticle

Alcoholism
Brain
brain
alcohol
Alcohols
36 Citations

Neuroimmune function and the consequences of alcohol exposure

Crews, F. T., Sarkar, D. K., Qin, L., Zou, J., Boyadjieva, N. & Vetreno, R. P., Jun 27 2015, In : Alcohol Research: Current Reviews. 37, 2

Research output: Contribution to journalReview article

Alcohols
Ethanol
Alcoholism
Cytokines
Genes
2014
29 Citations

Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain

Vetreno, R. P., Broadwater, M., Liu, W., Spear, L. P. & Crews, F. T., Nov 18 2014, In : PloS one. 9, 11, e113421.

Research output: Contribution to journalArticle

choline acetyltransferase
Choline O-Acetyltransferase
Neurons
Brain
Ethanol
44 Citations
Extracellular Matrix Proteins
Brain
Ethanol
Therapeutics
Reversal Learning
20 Citations

Current hypotheses on the mechanisms of alcoholism

Vetreno, R. P. & Crews, F. T., Jan 1 2014, In : Handbook of Clinical Neurology. 125, p. 477-497 21 p.

Research output: Contribution to journalArticle

Alcoholism
Executive Function
CREB-Binding Protein
Limbic System
Impulsive Behavior
16 Citations
Monocarboxylic Acid Transporters
Thiamine Deficiency
Thiamine
Thalamus
Acetate-CoA Ligase
40 Citations

Neuroimmune basis of alcoholic brain damage

Crews, F. T. & Vetreno, R. P., Jan 1 2014, In : International Review of Neurobiology. 118, p. 315-357 43 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Brain
Alcoholism
Oxidative Stress
Ethanol
37 Citations

Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure

Broadwater, M. A., Liu, W., Crews, F. T. & Spear, L. P., Jan 1 2014, In : Developmental Neuroscience. 36, 3-4, p. 297-305 9 p.

Research output: Contribution to journalArticle

Neurogenesis
Cell Death
Ethanol
Dentate Gyrus
Lateral Ventricles
77 Citations

Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling

Zou, J. Y. & Crews, F. T., Feb 14 2014, In : PloS one. 9, 2, e87915.

Research output: Contribution to journalArticle

Histone Deacetylases
histones
Brain
Ethanol
ethanol
2013
13 Citations

Comparison of Magnetic Resonance Imaging in Live vs. Post Mortem Rat Brains

Oguz, I., Yaxley, R., Budin, F., Hoogstoel, M., Lee, J., Maltbie, E., Liu, W. & Crews, F. T., Aug 13 2013, In : PloS one. 8, 8, e71027.

Research output: Contribution to journalArticle

magnetic resonance imaging
Rats
Brain
Magnetic Resonance Imaging
brain
99 Citations

High mobility group box 1/toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence

Crews, F. T., Qin, L., Sheedy, D., Vetreno, R. P. & Zou, J., Apr 1 2013, In : Biological psychiatry. 73, 7, p. 602-612 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 1
Alcoholism
Ethanol
Brain
Cytokines
60 Citations

Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking

Vetreno, R. P., Qin, L. & Crews, F. T., Nov 1 2013, In : Neurobiology of Disease. 59, p. 52-62 11 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Ethanol
Alcoholism
Drinking
Age of Onset
1 Citations

Innate immune signaling and alcoholism

Vetreno, R. P. & Crews, F. T., Oct 1 2013, Neural-Immune Interactions in Brain Function and Alcohol Related Disorders. Springer US, p. 251-278 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alcoholism
Immune System
Adaptive Immunity
Cytokines
Lipopolysaccharides
102 Citations

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

Qin, L., Liu, Y., Hong, J. S. & Crews, F. T., Jun 2013, In : GLIA. 61, 6, p. 855-868 14 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Substantia Nigra
Reactive Oxygen Species
Microglia
32 Citations

Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood

Ehlers, C. L., Liu, W., Wills, D. N. & Crews, F. T., Aug 6 2013, In : Neuroscience. 244, p. 1-15 15 p.

Research output: Contribution to journalArticle

Neurogenesis
Ethanol
Locomotion
Uridine
Caspase 3
17 Citations

Peri-adolescent ethanol vapor exposure produces reductions in hippocampal volume that are correlated with deficits in prepulse inhibition of the startle

Ehlers, C. L., Oguz, I., Budin, F., Wills, D. N. & Crews, F. T., Sep 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, 9, p. 1466-1475 10 p.

Research output: Contribution to journalArticle

Animals
Ethanol
Vapors
Diffusion tensor imaging
Diffusion Tensor Imaging
37 Citations
Corticotropin-Releasing Hormone
Brain
Ethanol
Cytokines
Messenger RNA
2012
68 Citations
Toll-Like Receptor 1
Binge Drinking
Prefrontal Cortex
Reversal Learning
Ethanol
37 Citations

ATP-P2X 7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation

Zou, J., Vetreno, R. P. & Crews, F. T., Apr 1 2012, In : GLIA. 60, 4, p. 661-673 13 p.

Research output: Contribution to journalArticle

Neuroglia
Adenosine Triphosphate
Cell Proliferation
Deoxyuridine
Aquaporin 4
73 Citations

Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration

Qin, L. & Crews, F. T., Jun 18 2012, In : Journal of Neuroinflammation. 9, 1, 130.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Poly I-C
Ethanol
Brain
Cytokines
6 Citations

Immune function genes, genetics, and the neurobiology of addiction

Crews, F. T., 2012, In : Alcohol research : current reviews. 34, 3, p. 355-361 7 p.

Research output: Contribution to journalEditorial

Neurobiology
Alcoholism
Genes
Innate Immunity
Immune System
59 Citations

Inflammasome-IL-1β signaling mediates ethanol inhibition of hippocampal neurogenesis

Zou, J. & Crews, F. T., Jun 18 2012, In : Frontiers in Neuroscience. MAY, Article 77.

Research output: Contribution to journalArticle

Inflammasomes
Neurogenesis
Ethanol
Alcoholics
Astrocytes
121 Citations
NADPH Oxidase
Reactive Oxygen Species
Ethanol
Alcohols
Prefrontal Cortex
27 Citations

Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis

Coleman, L. G., Oguz, I., Lee, J., Styner, M. & Crews, F. T., Sep 1 2012, In : Alcohol. 46, 6, p. 603-612 10 p.

Research output: Contribution to journalArticle

Neurogenesis
Neurons
Brain
brain
Ethanol
2011
25 Citations

Addiction, adolescence, and innate immune gene induction

Crews, F. T. & Vetreno, R. P., Dec 1 2011, In : Frontiers in Psychiatry. 2, APR, Article 19.

Research output: Contribution to journalReview article

Gene Expression
Substance-Related Disorders
Opiate Alkaloids
Genes
Neurogenesis