Darin J Knapp – Publications — University of North Carolina at Chapel Hill

2017

2 Citations

Age-related differences in anxiety-like behavior and amygdalar CCL2 responsiveness to stress following alcohol withdrawal in male Wistar rats

Harper, K. M., Knapp, D. J., Park, M. A. & Breese, G. R. Jan 1 2017 In : Psychopharmacology. 234, 1, p. 79-88 10 p.

Research output: Contribution to journal › Article

Wistar Rats

Anxiety

Alcohols

Behavior Control

A mouse model for chronic pain-induced increase in ethanol consumption

Butler, R. K., Knapp, D. J., Ulici, V., Longobardi, L., Loeser, R. F. & Breese, G. R. Jan 1 2017 In : Pain. 158, 3, p. 457-462 6 p.

Research output: Contribution to journal › Article

Chronic Pain

Tibial Meniscus

Ethanol

Alcoholism

Osteoarthritis

2016

3 Citations

Persistent adaptation by chronic alcohol is facilitated by neuroimmune activation linked to stress and CRF

Breese, G. R. & Knapp, D. J. May 1 2016 In : Alcohol. 52, p. 9-23 15 p.

Research output: Contribution to journal › Article

activation

Chemical activation

alcohol

Alcohols

withdrawal

2015

12 Citations

Withdrawal from Chronic Alcohol Induces a Unique CCL2 mRNA Increase in Adolescent But Not Adult Brain-Relationship to Blood Alcohol Levels and Seizures

Harper, K. M., Knapp, D. J. & Breese, G. R. Dec 1 2015 In : Alcoholism: Clinical and Experimental Research. 39, 12, p. 2375-2385 11 p.

Research output: Contribution to journal › Article

Brain

Seizures

Blood

Alcohols

Ligands

2013

20 Citations

Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J mice

Moy, S. S., Nonneman, R. J., Shafer, G. O., Nikolova, V. D., Riddick, N. V., Agster, K. L., Baker, L. K. & Knapp, D. J. Mar 2013 In : Neurotoxicology and Teratology. 36, p. 36-46 11 p.

Research output: Contribution to journal › Article

Dizocilpine Maleate

Fluoxetine

Amphetamine

Inbred C57BL Mouse

N-Methyl-D-Aspartate Receptors

31 Citations

The Cytokine mRNA Increase Induced by Withdrawal from Chronic Ethanol in the Sterile Environment of Brain is Mediated by CRF and HMGB1 Release

Whitman, B. A., Knapp, D. J., Werner, D. F., Crews, F. T. & Breese, G. R. 2013 In : Alcoholism: Clinical and Experimental Research. 37, 12, p. 2086-2097 12 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone

Brain

Ethanol

Cytokines

Messenger RNA

2012

12 Citations

Neuropeptide y signaling modulates the expression of ethanol-induced behavioral sensitization in mice

Hayes, D. M., Fee, J. R., McCown, T. J., Knapp, D. J., Breese, G. R., Cubero, I., Carvajal, F., Lerma-Cabrera, J. M., Navarro, M. & Thiele, T. E. Mar 2012 In : Addiction Biology. 17, 2, p. 338-350 13 p.

Research output: Contribution to journal › Article

Neuropeptides

Neuropeptide Y

Ethanol

Nucleus Accumbens

Dependovirus

2011

25 Citations

Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety

Knapp, D. J., Whitman, B. A., Wills, T. A., Angel, R. A., Overstreet, D. H., Criswell, H. E., Ming, Z. & Breese, G. R. Jun 1 2011 In : Brain, Behavior, and Immunity. 25, SUPPL. 1

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone

Ethanol

Anxiety

Cytokines

Neuroglia

13 Citations

Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P rats

Knapp, D. J., Overstreet, D. H., Huang, M., Wills, T. A., Whitman, B. A., Angel, R. A., Sinnett, S. E. & Breese, G. R. Nov 2011 In : Psychopharmacology. 218, 1, p. 179-189 11 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone

Ethanol

Anxiety

Alcohols

Drinking

2010

62 Citations

Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: Relation to stress-induced sensitization

Huang, M. M., Overstreet, D. H., Knapp, D. J., Angel, R., Wills, T. A., Navarro, M., Rivier, J., Vale, W. & Breese, G. R. Jan 2010 In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 298-307 10 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone

Ethanol

Anxiety

Brain

Microinjections

23 Citations

Interactions of stress and CRF in ethanol-withdrawal induced anxiety in adolescent and adult rats

Wills, T. A., Knapp, D. J., Overstreet, D. H. & Breese, G. R. Sep 2010 In : Alcoholism: Clinical and Experimental Research. 34, 9, p. 1603-1612 10 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone

Rats

Ethanol

Anxiety

Nutrition

18 Citations

Nerve growth factor (NGF) has novel antidepressant-like properties in rats

Overstreet, D. H., Fredericks, K., Knapp, D., Breese, G. & McMichael, J. Feb 1 2010 In : Pharmacology Biochemistry and Behavior. 94, 4, p. 553-560 8 p.

Research output: Contribution to journal › Article

Nerve Growth Factor

Antidepressive Agents

Rats

Fluoxetine

Serotonin

2009

10 Citations

A selective ALDH-2 inhibitor reduces anxiety in rats

Overstreet, D. H., Knapp, D. J., Breese, G. R. & Diamond, I. Dec 1 2009 In : Pharmacology Biochemistry and Behavior. 94, 2, p. 255-261 7 p.

Research output: Contribution to journal › Article

Rats

Anxiety

Anti-Anxiety Agents

Alcohols

GABA-A Receptors

37 Citations

Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats

Wills, T. A., Knapp, D. J., Overstreet, D. H. & Breese, G. R. Mar 2009 In : Alcoholism: Clinical and Experimental Research. 33, 3, p. 455-463 9 p.

Research output: Contribution to journal › Article

Rats

Ethanol

Anxiety

Pharmacology

Nutrition

31 Citations

The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling

Sparta, D. R., Ferraro, F. M., Fee, J. R., Knapp, D. J., Breese, G. R. & Thiele, T. E. Jan 2009 In : Alcoholism: Clinical and Experimental Research. 33, 1, p. 31-42 12 p.

Research output: Contribution to journal › Article

Self Administration

Inbred C57BL Mouse

Alcohols

Ethanol

Intraperitoneal Injections

2008

65 Citations

Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark procedures

Sparta, D. R., Sparrow, A. M., Lowery, E. G., Fee, J. R., Knapp, D. J. & Thiele, T. E. Feb 2008 In : Alcoholism: Clinical and Experimental Research. 32, 2, p. 259-265 7 p.

Research output: Contribution to journal › Article

Drinking

Ethanol

Blood

Bottles

Inbred C57BL Mouse

23 Citations

Decreased immunoreactivity of the melanocortin neuropeptide α-melanocyte-stimulating hormone (α-MSH) after chronic ethanol exposure in Sprague-Dawley rats

Navarro, M., Cubero, I., Knapp, D. J., Breese, G. R. & Thiele, T. E. Feb 2008 In : Alcoholism: Clinical and Experimental Research. 32, 2, p. 266-276 11 p.

Research output: Contribution to journal › Article

Melanocortins

alpha-MSH

Neuropeptides

Sprague Dawley Rats

Rats

24 Citations

Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: Effects on anxiety-like behavior and seizure thresholds

Wills, T. A., Knapp, D. J., Overstreet, D. H. & Breese, G. R. Aug 2008 In : Alcoholism: Clinical and Experimental Research. 32, 8, p. 1350-1360 11 p.

Research output: Contribution to journal › Article

Rats

Seizures

Blood

Ethanol

Anxiety

109 Citations

Distinct patterns of ΔFosB induction in brain by drugs of abuse

Perrotti, L. I., Weaver, R. R., Robison, B., Renthal, W., Maze, I., Yazdani, S., Elmore, R. G., Knapp, D. J., Selley, D. E., Martin, B. R., Sim-Selley, L., Bachtell, R. K., Self, D. W. & Nestler, E. J. May 2008 In : Synapse. 62, 5, p. 358-369 12 p.

Research output: Contribution to journal › Article

Street Drugs

Nucleus Accumbens

Brain

Pharmaceutical Preparations

Dronabinol

53 Citations

Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior

Breese, G. R., Knapp, D. J., Overstreet, D. H., Navarro, M., Wills, T. A. & Angel, R. A. Mar 1 2008 In : Neuropsychopharmacology. 33, 4, p. 867-876 10 p.

Research output: Contribution to journal › Article

Lipopolysaccharides

Ethanol

Anxiety

Cytokines

Diet

42 Citations

The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice

Lowery, E. G., Sparrow, A. M., Breese, G. R., Knapp, D. J. & Thiele, T. E. Feb 2008 In : Alcoholism: Clinical and Experimental Research. 32, 2, p. 240-248 9 p.

Research output: Contribution to journal › Article

Ethanol

Corticotropin-Releasing Hormone

Inbred C57BL Mouse

Drinking

Sucrose

2007

59 Citations

Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal

Knapp, D. J., Overstreet, D. H. & Breese, G. R. Apr 2007 In : Alcoholism: Clinical and Experimental Research. 31, 4, p. 582-595 14 p.

Research output: Contribution to journal › Article

Baclofen

Animals

Ethanol

Anxiety

Animal Models

43 Citations

Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats

Overstreet, D. H., Knapp, D. J. & Breese, G. R. Sep 2007 In : Alcoholism: Clinical and Experimental Research. 31, 9, p. 1473-1481 9 p.

Research output: Contribution to journal › Article

Alcohol Drinking

Rats

Anxiety

Alcohols

olanzapine

10 Citations

Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY)

Sparta, D. R., Fee, J. R., Knapp, D. J., Breese, G. R. & Thiele, T. E. Oct 8 2007 In : Drug and Alcohol Dependence. 90, 2-3, p. 297-300 4 p.

Research output: Contribution to journal › Article

Neuropeptide Y

Ethanol

Anxiety

anxiety

Nutrition

904 Citations

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J. S., Knapp, D. J. & Crews, F. T. Apr 1 2007 In : GLIA. 55, 5, p. 453-462 10 p.

Research output: Contribution to journal › Article

Receptors, Tumor Necrosis Factor, Type II

Brain

Microglia

Substantia Nigra

Inflammation

13 Citations

The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress

Knapp, D. J., Overstreet, D. H., Angel, R. A., Navarro, M. & Breese, G. R. Nov 2007 In : Alcoholism: Clinical and Experimental Research. 31, 11, p. 1872-1882 11 p.

Research output: Contribution to journal › Article

Flumazenil

Anti-Anxiety Agents

Amygdala

Ethanol

Anxiety

2006

13 Citations

Increased consumption but not operant self-administration of ethanol in mice lacking the RIIβ subunit of protein kinase A

Ferraro, F. M., Sparta, D. R., Knapp, D. J., Breese, G. R. & Thiele, T. E. May 2006 In : Alcoholism: Clinical and Experimental Research. 30, 5, p. 825-835 11 p.

Research output: Contribution to journal › Article

Self Administration

Cyclic AMP-Dependent Protein Kinases

Ethanol

Bottles

Consummatory Behavior

8 Citations

Involvement of protein kinase A in ethanol-induced locomotor activity and sensitization

Fee, J. R., Knapp, D. J., Sparta, D. R., Breese, G. R., Picker, M. J. & Thiele, T. E. May 11 2006 In : Neuroscience. 140, 1, p. 21-31 11 p.

Research output: Contribution to journal › Article

Locomotion

Cyclic AMP-Dependent Protein Kinases

Ethanol

Injections

Genetic Testing

39 Citations

Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands

Overstreet, D. H., Knapp, D. J., Angel, R. A., Navarro, M. & Breese, G. R. Jul 2006 In : Psychopharmacology. 187, 1, p. 1-12 12 p.

Research output: Contribution to journal › Article

Serotonin

Ethanol

Anxiety

Ligands

Injections

2005

33 Citations

Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains

Hayes, D. M., Knapp, D. J., Breese, G. R. & Thiele, T. E. May 2005 In : Alcoholism: Clinical and Experimental Research. 29, 5, p. 721-729 9 p.

Research output: Contribution to journal › Article

Inbred Strains Mice

Neuropeptide Y

Corticotropin-Releasing Hormone

Drinking

Inbred DBA Mouse

112 Citations

Conceptual framework for the etiology of alcoholism: A "kindling" /stress hypothesis

Breese, G. R., Overstreet, D. H. & Knapp, D. J. Apr 2005 In : Psychopharmacology. 178, 4, p. 367-380 14 p.

Research output: Contribution to journal › Article

Alcoholism

Anxiety

Alcohols

Recurrence

Substance Withdrawal Syndrome

42 Citations

Effects of melanocortin receptor activation and blockade on ethanol intake: A possible role for the melanocortin-4 receptor

Navarro, M., Cubero, I., Chen, A. S., Chen, H. Y., Knapp, D. J., Breese, G. R., Marsh, D. J. & Thiele, T. E. Jun 2005 In : Alcoholism: Clinical and Experimental Research. 29, 6, p. 949-957 9 p.

Research output: Contribution to journal › Article

Melanocortin Receptors

Receptor, Melanocortin, Type 4

Ethanol

Chemical activation

Melanocortins

2 Citations

Factors mediating alcohol craving and relapse: Stress, compulsivity, and genetics

Rodd, Z. A., Anstrom, K. K., Knapp, D. J., Racz, I., Zimmer, A., Serra, S., Bell, R. L., Woodward, D. J., Breese, G. R. & Colombo, G. Jul 2005 In : Alcoholism: Clinical and Experimental Research. 29, 7, p. 1325-1333 9 p.

Research output: Contribution to journal › Article

Alcohols

Rats

Recurrence

Drinking

Ethanol

32 Citations

Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/γ- aminobutyric acid ligands

Knapp, D. J., Overstreet, D. H. & Breese, G. R. Apr 2005 In : Alcoholism: Clinical and Experimental Research. 29, 4, p. 553-563 11 p.

Research output: Contribution to journal › Article

Benzodiazepines

gamma-Aminobutyric Acid

Ethanol

Anxiety

Modulation

20 Citations

Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats

Overstreet, D. H., Knapp, D. J. & Breese, G. R. May 1 2005 In : Pharmacology Biochemistry and Behavior. 81, 1, p. 122-130 9 p.

Research output: Contribution to journal › Article

Sprague Dawley Rats

Rats

Ethanol

Anxiety

Alcohols

94 Citations

Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: Inhibition by CRF₁- and benzodiazepine-receptor antagonists and a 5-HT_1a-receptor agonist

Breese, G. R., Overstreet, D. H., Knapp, D. J. & Navarro, M. Sep 1 2005 In : Neuropsychopharmacology. 30, 9, p. 1662-1669 8 p.

Research output: Contribution to journal › Article

Serotonin Antagonists

GABA-A Receptors

Ethanol

Anxiety

Interpersonal Relations

152 Citations

Stress enhancement of craving during sobriety: A risk for relapse

Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Lê, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R. & Weiss, F. Feb 2005 In : Alcoholism: Clinical and Experimental Research. 29, 2, p. 185-195 11 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone

Anxiety

Alcohols

Recurrence

Alcoholics

2004

17 Citations

Integrative Neurobiology of the Alcohol Withdrawal Syndrome - From Anxiety to Seizures

Faingold, C. L., Knapp, D. J., Chester, J. A. & Gonzalez, L. P. Feb 2004 In : Alcoholism: Clinical and Experimental Research. 28, 2, p. 268-278 11 p.

Research output: Contribution to journal › Article

Neurobiology

Seizures

Anxiety

Alcohols

Alcohol Withdrawal Seizures

117 Citations

Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF₁ receptors

Overstreet, D. H., Knapp, D. J. & Breese, G. R. Jan 1 2004 In : Pharmacology Biochemistry and Behavior. 77, 2, p. 405-413 9 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone

Ethanol

Anxiety

Modulation

Rats

25 Citations

Peripheral and central administration of a selective neuropeptide Y Y1 receptor antagonist suppresses ethanol intake by C57BL/6J mice

Sparta, D. R., Fee, J. R., Hayes, D. M., Knapp, D. J., MacNeil, D. J. & Thiele, T. E. Sep 2004 In : Alcoholism: Clinical and Experimental Research. 28, 9, p. 1324-1330 7 p.

Research output: Contribution to journal › Article

Inbred C57BL Mouse

Ethanol

Neuropeptide Y

Intraventricular Infusions

Locomotion

31 Citations

Predictors of high ethanol consumption in RIIβ knock-out mice: Assessment of anxiety and ethanol-induced sedation

Fee, J. R., Sparta, D. R., Knapp, D. J., Breese, G. R., Picker, M. J. & Thiele, T. E. Oct 2004 In : Alcoholism: Clinical and Experimental Research. 28, 10, p. 1459-1468 10 p.

Research output: Contribution to journal › Article

Knockout Mice

Ethanol

Anxiety

Hypnotics and Sedatives

Cyclic AMP-Dependent Protein Kinases

105 Citations

SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats

Knapp, D. J., Overstreet, D. H., Moy, S. S. & Breese, G. R. Feb 1 2004 In : Alcohol. 32, 2, p. 101-111 11 p.

Research output: Contribution to journal › Article

Flumazenil

Interpersonal Relations

withdrawal

Rats

Serotonin

33 Citations

Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol

Overstreet, D. H., Knapp, D. J. & Breese, G. R. Jul 1 2004 In : Pharmacology Biochemistry and Behavior. 78, 3, p. 459-464 6 p.

Research output: Contribution to journal › Article

Rats

Ethanol

Anxiety

Interpersonal Relations

Nutrition

86 Citations

Stress sensitization of ethanol withdrawal-induced reduction in social interaction: Inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT_1A-receptor agonist

Breese, G. R., Knapp, D. J. & Overstreet, D. H. Mar 1 2004 In : Neuropsychopharmacology. 29, 3, p. 470-482 13 p.

Research output: Contribution to journal › Article

Corticotropin-Releasing Hormone Receptors

Serotonin Antagonists

GABA-A Receptors

Interpersonal Relations

Ethanol

36 Citations

Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: Implications for NMDA receptor involvement

Papadeas, S. T., Blake, B. L., Knapp, D. J. & Breese, G. R. Jun 30 2004 In : Journal of Neuroscience. 24, 26, p. 5863-5876 14 p.

Research output: Contribution to journal › Article

Mitogen-Activated Protein Kinase 3

Oxidopamine

Mitogen-Activated Protein Kinase 1

Dopamine Agonists

Extracellular Signal-Regulated MAP Kinases

2003

70 Citations

A 5-HT_1A agonist and a 5-HT_2C antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats

Overstreet, D. H., Knapp, D. J., Moy, S. S. & Breese, G. R. Jan 1 2003 In : Psychopharmacology. 167, 4, p. 344-352 9 p.

Research output: Contribution to journal › Article

Serotonin Receptor Agonists

Interpersonal Relations

Ethanol

Serotonin

Buspirone

81 Citations

Involvement of 5-HT1A receptors in animal tests of anxiety and depression: Evidence from genetic models

Overstreet, D. H., Commissaris, R. C., De la Garza, R., File, S. E., Knapp, D. J. & Seiden, L. S. Jun 2003 In : Stress. 6, 2, p. 101-110 10 p.

Research output: Contribution to journal › Article

Receptor, Serotonin, 5-HT1A

Genetic Models

Serotonin

Anxiety

Depression

37 Citations

MTII-induced reduction of voluntary ethanol drinking is blocked by pretreatment with AgRP-(83-132)

Navarro, M., Cubero, I., Knapp, D. J. & Thiele, T. E. Jan 1 2003 In : Neuropeptides. 37, 6, p. 338-344 7 p.

Research output: Contribution to journal › Article

Drinking

Ethanol

Intraperitoneal Injections

agouti-related protein-(83-132)

melanotan-II

2002

121 Citations

Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawals

Overstreet, D. H., Knapp, D. J. & Breese, G. R. Aug 2002 In : Alcoholism: Clinical and Experimental Research. 26, 8, p. 1259-1268 10 p.

Research output: Contribution to journal › Article

Interpersonal Relations

Rats

Ethanol

Nutrition

Diet

2001

38 Citations

Differential modulation of GABA- and NMDA-gated currents by ethanol and isoflurane in cultured rat cerebral cortical neurons

Ming, Z., Knapp, D. J., Mueller, R. A., Breese, G. R. & Criswell, H. E. Nov 30 2001 In : Brain Research. 920, 1-2, p. 117-124 8 p.

Research output: Contribution to journal › Article

Isoflurane

N-Methylaspartate

gamma-Aminobutyric Acid

Ethanol

Neurons