Research Output 2001 2018

  • 1788 Citations
  • 20 h-Index
  • 32 Article
  • 2 Chapter
  • 1 Comment/debate
2018

Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth

Jin, Q., Qiao, C., Li, J., Li, J. & Xiao, X. Apr 4 2018 In : Molecular Therapy. 26, 4, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

Dependovirus
Viral Genes
Skeletal Muscle
Growth
Forelimb
2017

Adeno-Associated Virus–Mediated Mini-Agrin Delivery Is Unable to Rescue Disease Phenotype in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2I

Vannoy, C. H., Zhou, H., Qiao, C., Xiao, X., Bang, A. G. & Lu, Q. L. Feb 1 2017 In : American Journal of Pathology. 187, 2, p. 431-440 10 p.

Research output: Contribution to journalArticle

Agrin
Dependovirus
Phenotype
Dystroglycans
Laminin
1 Citations

Follistatin N terminus differentially regulates muscle size and fat in vivo

Zheng, H., Qiao, C., Tang, R., Li, J., Bulaklak, K., Huang, Z., Zhao, C., Dai, Y., Li, J. & Xiao, X. Sep 15 2017 In : Experimental & molecular medicine. 49, 9, p. e377

Research output: Contribution to journalArticle

Follistatin
Fats
Muscles
Myostatin
Activins
2015
5 Citations

Overcoming insulin insufficiency by forced follistatin expression in β-cells of db/db mice

Zhao, C., Qiao, C., Tang, R. H., Jiang, J., Li, J., Martin, C. B., Bulaklak, K., Li, J., Wang, D. W. & Xiao, X. Jan 1 2015 In : Molecular Therapy. 23, 5, p. 866-874 9 p.

Research output: Contribution to journalArticle

Follistatin
Insulin
Pancreas
Cell Proliferation
Myostatin
2014
4 Citations

K137R Mutation on adeno-associated viral capsids had minimal effect on enhancing gene delivery in vivo

Qiao, C., Li, C., Zhao, C., Li, J., Bian, T., Grieger, J., Li, J., Samulski, R. J. & Xiao, X. Feb 1 2014 In : Human gene therapy methods. 25, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Capsid
Mutation
Lac Operon
Luciferases
Transgenes
12 Citations

Muscle and heart function restoration in a limb girdle muscular dystrophy 2I (LGMD2I) mouse model by systemic FKRP gene delivery

Qiao, C., Wang, C. H., Zhao, C., Lu, P., Awano, H., Xiao, B., Li, J., Yuan, Z., Dai, Y., Martin, C. B., Li, J., Lu, Q. & Xiao, X. Jul 22 2014 In : Molecular Therapy. 22, 11, p. 1890-1899 10 p.

Research output: Contribution to journalArticle

Limb-Girdle Muscular Dystrophies
Myocardium
Walker-Warburg Syndrome
Dystroglycans
Genetic Therapy
2013
26 Citations

Adeno-associated Virus 9 mediated FKRP gene therapy restores functional glycosylation of α-dystroglycan and improves muscle functions

Xu, L., Lu, P. J., Wang, C. H., Keramaris, E., Qiao, C., Xiao, B., Blake, D. J., Xiao, X. & Lu, Q. L. Oct 1 2013 In : Molecular Therapy. 21, 10, p. 1832-1840 9 p.

Research output: Contribution to journalArticle

Walker-Warburg Syndrome
Dystroglycans
Dependovirus
Muscular Dystrophies
Glycosylation
5 Citations

Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints

Lee, H. H., O'Malley, M. J., Friel, N. A., Payne, K. A., Qiao, C., Xiao, X. & Chu, C. R. Apr 1 2013 In : Human Gene Therapy. 24, 4, p. 457-466 10 p.

Research output: Contribution to journalArticle

Dependovirus
Transgenes
Joints
Injections
Luciferases
5 Citations

Production and Characterization of Novel Recombinant Adeno-Associated Virus Replicative-Form Genomes: A Eukaryotic Source of DNA for Gene Transfer

Li, L., Dimitriadis, E. K., Yang, Y., Li, J., Yuan, Z., Qiao, C., Beley, C., Smith, R. H., Garcia, L. & Kotin, R. M. Aug 1 2013 In : PLoS ONE. 8, 8, e69879

Research output: Contribution to journalArticle

Dependovirus
Gene transfer
Viruses
gene transfer
Transgenes
2012
38 Citations

Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure inδ-sarcoglycan-deficient hamsters

He, B., Tang, R. H., Weisleder, N., Xiao, B., Yuan, Z., Cai, C., Zhu, H., Lin, P., Qiao, C., Li, J., Mayer, C., Li, J., Ma, J. & Xiao, X. Apr 1 2012 In : Molecular Therapy. 20, 4, p. 727-735 9 p.

Research output: Contribution to journalArticle

Sarcoglycans
Muscular Dystrophies
Cricetinae
Heart Failure
Muscles
14 Citations

Single tyrosine mutation in AAV8 and AAV9 capsids is insufficient to enhance gene delivery to skeletal muscle and heart

Qiao, C., Yuan, Z., Li, J., Tang, R., Li, J. & Xiao, X. Feb 1 2012 In : Human Gene Therapy Methods. 23, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Capsid
Tyrosine
Skeletal Muscle
Mutation
Genes
2011
11 Citations
Dependovirus
Cell Line
Product Packaging
Transfection
Plasmids
6 Citations

Gene therapy in skeletal muscle mediated by adeno-associated virus vectors

Qiao, C., Koo, T., Li, J., Xiao, X. & Dickson, J. G. Dec 19 2011 Adeno-Associated Virus: Methods and Protocols. Vol. 807, p. 119-140 22 p. (Methods in Molecular Biology; vol. 807)

Research output: Chapter in Book/Report/Conference proceedingChapter

Dependovirus
Genetic Therapy
Skeletal Muscle
Muscles
Transgenes
65 Citations

Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver

Qiao, C., Yuan, Z., Li, J., He, B., Zheng, H., Mayer, C., Li, J. & Xiao, X. Apr 1 2011 In : Gene Therapy. 18, 4, p. 403-410 8 p.

Research output: Contribution to journalArticle

Dependovirus
MicroRNAs
Transgenes
Liver
Luciferases
8 Citations

Post-natal knockdown of fukutin-related protein expression in muscle by long-term RNA interference induces dystrophic pathology

Wang, C. H., Chan, Y. M., Tang, R. H., Xiao, B., Lu, P., Keramaris-Vrantsis, E., Zheng, H., Qiao, C., Jiang, J., Li, J., Ma, H. I., Lu, Q. & Xiao, X. Jan 1 2011 In : American Journal of Pathology. 178, 1, p. 261-272 12 p.

Research output: Contribution to journalArticle

Limb-Girdle Muscular Dystrophies
RNA Interference
Small Interfering RNA
Pathology
Muscles
21 Citations

Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees

Payne, K. A., Lee, H. H., Haleem, A. M., Martins, C., Yuan, Z., Qiao, C., Xiao, X. & Chu, C. R. Aug 1 2011 In : Osteoarthritis and Cartilage. 19, 8, p. 1058-1065 8 p.

Research output: Contribution to journalArticle

Intra-Articular Injections
Dependovirus
Transgenes
Viruses
Tetracycline
2010
45 Citations

Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle

Qiao, C., Zhang, W., Yuan, Z., Shin, J. H., Li, J., Jayandharan, G. R., Zhong, L., Srivastava, A., Xiao, X. & Duan, D. Oct 1 2010 In : Human Gene Therapy. 21, 10, p. 1343-1348 6 p.

Research output: Contribution to journalArticle

Dependovirus
Capsid
Phenylalanine
Genetic Therapy
Tyrosine
26 Citations

Efficient retrograde transport of adeno-associated virus type 8 to spinal cord and dorsal root ganglion after vector delivery in muscle

Zheng, H., Qiao, C., Wang, C. H., Li, J., Li, J., Yuan, Z., Zhang, C. & Xiao, X. Jan 1 2010 In : Human Gene Therapy. 21, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

Dependovirus
Spinal Nerve Roots
Spinal Ganglia
Spinal Cord
Muscles

Muscular dystrophy gene therapy in small animal models

Qiao, C. & Xiao, X. 2010 Muscle Gene Therapy. Springer New York, p. 55-68 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene therapy
Muscular Dystrophies
Genetic Therapy
Dystrophin
Animals
79 Citations

Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs

Kornegay, J. N., Li, J., Bogan, J. R., Bogan, D. J., Chen, C., Zheng, H., Wang, B., Qiao, C., Howard, J. F. & Xiao, X. Aug 1 2010 In : Molecular Therapy. 18, 8, p. 1501-1508 8 p.

Research output: Contribution to journalArticle

Dystrophin
Intravenous Injections
Dogs
Muscles
Extremities
2009
37 Citations

A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery

Yu, C. Y., Yuan, Z., Cao, Z., Wang, B., Qiao, C., Li, J. & Xiao, X. Jun 5 2009 In : Gene Therapy. 16, 8, p. 953-962 10 p.

Research output: Contribution to journalArticle

Tropism
Dependovirus
Muscles
Peptides
Heparin
111 Citations

A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection

Yang, L., Jiang, J., Drouin, L. M., Agbandje-Mckenna, M., Chen, C., Qiao, C., Pu, D., Hu, X., Wang, D. Z., Li, J. & Xiao, X. Mar 10 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3946-3951 6 p.

Research output: Contribution to journalArticle

DNA Shuffling
Dependovirus
Capsid
Myocardium
Muscles
61 Citations

Hydrodynamic limb vein injection of adeno-associated virus serotype 8 vector carrying canine myostatin propeptide gene into normal dogs enhances muscle growth

Qiao, C., Li, J., Zheng, H., Bogan, J., Li, J., Yuan, Z., Zhang, C., Bogan, D., Kornegay, J. & Xiao, X. Jan 1 2009 In : Human Gene Therapy. 20, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Myostatin
Dependovirus
Hydrodynamics
Canidae
Veins
2008
28 Citations

A canine minidystrophin is functional and therapeutic in mdx mice

Wang, B., Li, J., Qiao, C., Chen, C., Hu, P., Zhu, X., Zhou, L., Bogan, J., Kornegay, J. & Xiao, X. Aug 1 2008 In : Gene Therapy. 15, 15, p. 1099-1106 8 p.

Research output: Contribution to journalArticle

Inbred mdx Mouse
Canidae
Dependovirus
Muscular Dystrophies
Dogs
105 Citations

Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice

Qiao, C., Li, J., Jiang, J., Zhu, X., Wang, B., Li, J. & Xiao, X. Mar 1 2008 In : Human Gene Therapy. 19, 3, p. 241-253 13 p.

Research output: Contribution to journalArticle

Myostatin
Inbred mdx Mouse
Dependovirus
Phenotype
Muscles
2007
152 Citations

Relationships between transforming growth factor-β1, myostatin, and decorin: Implications for skeletal muscle fibrosis

Zhu, J., Li, Y., Shen, W., Qiao, C., Ambrosio, F., Lavasani, M., Nozaki, M., Branca, M. F. & Huard, J. Aug 31 2007 In : Journal of Biological Chemistry. 282, 35, p. 25852-25863 12 p.

Research output: Contribution to journalArticle

Myostatin
Decorin
Transforming Growth Factors
Muscle
Skeletal Muscle
2005
410 Citations

Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart

Wang, Z., Zhu, T., Qiao, C., Zhou, L., Wang, B., Zhang, J., Chen, C., Li, J. & Xiao, X. Mar 1 2005 In : Nature biotechnology. 23, 3, p. 321-328 8 p.

Research output: Contribution to journalArticle

Dependovirus
Viruses
Blood Vessels
Muscle
Myocardium
69 Citations

Amelioration of laminin-α2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin

Qiao, C., Li, J., Zhu, T., Draviam, R., Watkins, S., Ye, X., Chen, C., Li, J. & Xiao, X. Aug 23 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 11999-12004 6 p.

Research output: Contribution to journalArticle

Muscular Dystrophies
Laminin
Muscles
Genes
Agrin
15 Citations

Induction of tumor immunity and cytotoxic t lymphocyte responses using dendritic cells transduced by adenoviral vectors encoding HBsAg: Comparison to protein immunization

Qiu, S. J., Lu, L., Qiao, C., Wang, L. F., Wang, Z., Xiao, X., Qian, S., Fung, J. J., Ye, S. L. & Bonham, C. A. Jul 1 2005 In : Journal of Cancer Research and Clinical Oncology. 131, 7, p. 429-438 10 p.

Research output: Contribution to journalArticle

Hepatitis B Surface Antigens
Dendritic Cells
Immunity
Immunization
Lymphocytes
73 Citations

Sustained whole-body functional rescue in congestive heart failure and muscular dystrophy hamsters by systemic gene transfer

Zhu, T., Zhou, L., Mori, S., Wang, Z., McTiernan, C. F., Qiao, C., Chen, C., Wang, D. W., Li, J. & Xiao, X. Oct 25 2005 In : Circulation. 112, 17, p. 2650-2659 10 p.

Research output: Contribution to journalArticle

Muscular Dystrophies
Sarcoglycans
Cricetinae
Heart Failure
Dependovirus
2003
81 Citations

Increased atherosclerotic lesions in ApoE mice with plasma phospholipid transfer protein overexpression

Yang, X. P., Yan, D., Qiao, C., Liu, R. J., Chen, J. G., Li, J., Schneider, M., Lagrost, L., Xiao, X. & Jiang, X. C. Sep 1 2003 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 23, 9, p. 1601-1607 7 p.

Research output: Contribution to journalArticle

Phospholipid Transfer Proteins
Apolipoproteins E
Blood Proteins
Satellite Viruses
Lipoproteins
2002
40 Citations

A novel gene expression control system and its use in stable, high-titer 293 cell-based adeno-associated virus packaging cell lines

Qiao, C., Wang, B., Zhu, X., Li, J. & Xiao, X. Dec 2002 In : Journal of Virology. 76, 24, p. 13015-13027 13 p.

Research output: Contribution to journalArticle

Dependovirus
Virus Assembly
cell lines
Gene Expression
Cell Line
30 Citations

Feasibility of generating adeno-associated virus packaging cell lines containing inducible adenovirus helper genes

Qiao, C., Li, J., Skold, A., Zhang, X. & Xiao, X. 2002 In : Journal of Virology. 76, 4, p. 1904-1913 10 p.

Research output: Contribution to journalArticle

Dependovirus
Virus Assembly
Adenoviridae
cell lines
Cell Line
2001
205 Citations

Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency

Jiang, X. C., Qin, S., Qiao, C., Kawano, K., Lin, M., Skold, A., Xiao, X. & Tall, A. R. Aug 9 2001 In : Nature Medicine. 7, 7, p. 847-852 6 p.

Research output: Contribution to journalArticle

Phospholipid Transfer Proteins
Protein Deficiency
Apolipoproteins B
Atherosclerosis
Apolipoproteins E

Erratum: Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency (Nature Medicine (2001) 7 (847-852))

Jiang, X. C., Qin, S., Qiao, C., Kawano, K., Lin, M., Skold, A., Xiao, X. & Tall, A. R. Aug 29 2001 In : Nature Medicine. 7, 8, 1 p.

Research output: Contribution to journalComment/debate

Protein Deficiency
Bioethanol
Apolipoproteins B
Atherosclerosis
Medicine