• 37552 Citations
  • 104 h-Index
1978 …2019
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  • 27 Similar Profiles
ras Proteins Medicine & Life Sciences
Monomeric GTP-Binding Proteins Medicine & Life Sciences
Proteins Medicine & Life Sciences
Guanine Nucleotide Exchange Factors Medicine & Life Sciences
Growth Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Guanosine Triphosphate Medicine & Life Sciences
Chemical activation Chemical Compounds

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Projects 1986 2019

Research Output 1978 2018

1 Citations

Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers

Lawson, C. D. & Der, C. J. Jul 4 2018 In : Small GTPases. 9, 4, p. 290-296 7 p.

Research output: Contribution to journalComment/debate

Oncogenes
Breast Neoplasms
GTPase-Activating Proteins
GTP Phosphohydrolases
Neoplasms
1 Citations

A KRAS GTPase K104Q mutant retains downstream signaling by offsetting defects in regulation

Yin, G., Kistler, S., George, S. D., Kuhlmann, N., Garvey, L., Huynh, M., Bagni, R. K., Lammers, M., Der, C. J. & Campbell, S. L. Mar 17 2017 In : Journal of Biological Chemistry. 292, 11, p. 4446-4456 11 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
GTP Phosphohydrolases
GTPase-Activating Proteins
Defects
Acetylation
2 Citations

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

Anderson, G. R. , Winter, P. S. , Lin, K. H. , Nussbaum, D. P. , Cakir, M. , Stein, E. M. , Soderquist, R. S. , Crawford, L. , Leeds, J. C. , Newcomb, R. , Stepp, P. , Yip, C. , Wardell, S. E. , Tingley, J. P. , Ali, M. , Xu, M. , Ryan, M. , McCall, S. J. , McRee, A. J. , Counter, C. M. & 2 others Der, C. J. & Wood, K. C. Jul 25 2017 In : Cell Reports. 20, 4, p. 999-1015 17 p.

Research output: Contribution to journalArticle

23 Citations

Drugging RAS: Know the enemy

Papke, B. & Der, C. J. Mar 17 2017 In : Science. 355, 6330, p. 1158-1163 6 p.

Research output: Contribution to journalReview article

Neoplasms
Growth and Development
Oncogenes
Genes
Technology
17 Citations

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P. Feb 13 2017 In : Cancer Cell. 31, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

Epithelial Cells
Ribosomal DNA
Guanine Nucleotide Exchange Factors
Carcinogenesis
EphA2 Receptor