• 38196 Citations
  • 105 h-Index
1978 …2019
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  • 22 Similar Profiles
ras Proteins Medicine & Life Sciences
Proteins Medicine & Life Sciences
Monomeric GTP-Binding Proteins Medicine & Life Sciences
Guanine Nucleotide Exchange Factors Medicine & Life Sciences
Chemical activation Chemical Compounds
Growth Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
rho GTP-Binding Proteins Medicine & Life Sciences

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Projects 1986 2019

Research Output 1978 2018

Computational design of chemogenetic and optogenetic split proteins

Dagliyan, O., Krokhotin, A., Ozkan-Dagliyan, I., Deiters, A., Der, C. J., Hahn, K. M. & Dokholyan, N. V., Dec 1 2018, In : Nature Communications. 9, 1, 4042.

Research output: Contribution to journalArticle

protein
hypothesis testing
biological processes
ligand
prediction
1 Citations

Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers

Lawson, C. D. & Der, C. J., Jul 4 2018, In : Small GTPases. 9, 4, p. 290-296 7 p.

Research output: Contribution to journalComment/debate

Oncogenes
Breast Neoplasms
GTPase-Activating Proteins
GTP Phosphohydrolases
Neoplasms

KRAS: The critical driver and therapeutic target for pancreatic cancer

Waters, A. M. & Der, C. J., Sep 1 2018, In : Cold Spring Harbor Perspectives in Medicine. 8, 9, a031435.

Research output: Contribution to journalArticle

Ports and harbors
Protein Isoforms
Genes

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 othersDer, C. J., Jan 1 2018, (Accepted/In press) In : Cancer Cell.

Research output: Contribution to journalArticle

Adenocarcinoma
Ubiquitin-Protein Ligases
Protein Stability
Proteasome Endopeptidase Complex
Growth
1 Citations

A KRAS GTPase K104Q mutant retains downstream signaling by offsetting defects in regulation

Yin, G., Kistler, S., George, S. D., Kuhlmann, N., Garvey, L., Huynh, M., Bagni, R. K., Lammers, M., Der, C. J. & Campbell, S. L., Mar 17 2017, In : Journal of Biological Chemistry. 292, 11, p. 4446-4456 11 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
GTP Phosphohydrolases
GTPase-Activating Proteins
Defects
Acetylation