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  • 12 Similar Profiles
Serotonin Medicine & Life Sciences
Serotonin Receptors Medicine & Life Sciences
Ligands Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Receptor, Serotonin, 5-HT2A Medicine & Life Sciences
salvinorin A Medicine & Life Sciences
Antipsychotic Agents Medicine & Life Sciences
kappa Opioid Receptor Medicine & Life Sciences

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Projects 1994 2019

Research Output 1980 2017

31 Citations

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Wacker, D., Wang, S., McCorvy, J. D., Betz, R. M., Venkatakrishnan, A. J., Levit, A., Lansu, K., Schools, Z. L., Che, T., Nichols, D. E., Shoichet, B. K., Dror, R. O. & Roth, B. L. Jan 26 2017 In : Cell. 168, 3, p. 377-389.e12

Research output: Contribution to journalArticle

Lysergic Acid Diethylamide
Serotonin Receptors
Crystal structure
Serotonin
Kinetics
17 Citations

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, K., Karpiak, J., Liu, J., Huang, X. P., McCorvy, J. D., Kroeze, W. K., Che, T., Nagase, H., Carroll, F. I., Jin, J., Shoichet, B. K. & Roth, B. L. May 1 2017 In : Nature Chemical Biology. 13, 5, p. 529-536 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Mast Cells
Computer Simulation
Hydrocodone
Dextromethorphan
6 Citations

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

Chan, J. D., McCorvy, J. D., Acharya, S., Johns, M. E., Day, T. A., Roth, B. L. & Marchant, J. S. May 1 2016 In : PLoS Pathogens. 12, 5, e1005651

Research output: Contribution to journalArticle

Schistosoma mansoni
G-Protein-Coupled Receptors
Parasites
Anthelmintics
Platyhelminths
1 Citations

An alerting structure: Human orexin receptor 1

Wacker, D. & Roth, B. L. Apr 5 2016 In : Nature Structural and Molecular Biology. 23, 4, p. 265-266 2 p.

Research output: Contribution to journalShort survey

Intracellular Signaling Peptides and Proteins
Orexin Receptors
G-Protein-Coupled Receptors
Orexin Receptor Antagonists
23 Citations

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Marchant, N. J., Whitaker, L. R., Bossert, J. M., Harvey, B. K., Hope, B. T., Kaganovsky, K., Adhikary, S., Prisinzano, T. E., Vardy, E., Roth, B. L. & Shaham, Y. Jan 1 2016 In : Neuropsychopharmacology. 41, 2, p. 402-409 8 p.

Research output: Contribution to journalArticle

Designer Drugs
kappa Opioid Receptor
Mesencephalon
Brain
Ventral Tegmental Area