• 32799 Citations
  • 93 h-Index
1980 …2019
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  • 10 Similar Profiles
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salvinorin A Medicine & Life Sciences
Antipsychotic Agents Medicine & Life Sciences
kappa Opioid Receptor Medicine & Life Sciences

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Projects 1994 2019

Research Output 1980 2018

Activation mechanisms for a universal signalling protein news-and-views

Krumm, B. & Roth, B. L. May 17 2018 In : Nature. 557, 7705, p. 318-319 2 p.

Research output: Contribution to journalArticle

Arrestin
Drug Discovery
G-Protein-Coupled Receptors
Proteins
1 Citations

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines

Pera, T., Deshpande, D. A., Ippolito, M., Wang, B., Gavrila, A., Michael, J. V., Nayak, A. P., Tompkins, E., Farrell, E., Kroeze, W. K., Roth, B. L., Panettieri, R. A., Benovic, J. L., An, S. S., Dulin, N. O. & Penn, R. B. Feb 1 2018 In : FASEB Journal. 32, 2, p. 862-874 13 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Protons
Asthma
GTP-Binding Proteins
Ligands
1 Citations

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

Qin, S., Meng, M., Yang, D., Bai, W., Lu, Y., Peng, Y., Song, G., Wu, Y., Zhou, Q., Zhao, S., Huang, X., McCorvy, J. D., Cai, X., Dai, A., Roth, B. L., Hanson, M. A., Liu, Z. J., Wang, M. W., Stevens, R. C. & Shui, W. Jan 1 2018 In : Chemical Science. 9, 12, p. 3192-3199 8 p.

Research output: Contribution to journalArticle

Modulators
Mass spectrometry
Screening
Throughput
Proteins
3 Citations

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Baumann, M. H., Majumdar, S., Le Rouzic, V., Hunkele, A., Uprety, R., Huang, X. P., Xu, J., Roth, B. L., Pan, Y. X. & Pasternak, G. W. May 15 2018 In : Neuropharmacology. 134, p. 101-107 7 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Street Drugs
Analgesia
Opioid Analgesics
Pharmacology
3 Citations

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

McCorvy, J. D., Butler, K. V., Kelly, B., Rechsteiner, K., Karpiak, J., Betz, R. M., Kormos, B. L., Shoichet, B. K., Dror, R. O., Jin, J. & Roth, B. L. Feb 1 2018 In : Nature Chemical Biology. 14, 2, p. 126-134 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Ligands
Arrestin
beta-Arrestins
Drug Design