Research Output 1987 2017

  • 2559 Citations
  • 26 h-Index
  • 49 Article
  • 2 Comment/debate
2017
2 Citations

A dual pathogenic mechanism links tau acetylation to sporadic tauopathy

Trzeciakiewicz, H., Tseng, J. H., Wander, C. M., Madden, V., Tripathy, A., Yuan, C. X. & Cohen, T. J. Mar 13 2017 In : Scientific Reports. 7, 44102

Research output: Contribution to journalArticle

Tauopathies
Acetylation
Microtubules
Alzheimer Disease
Pathology
2016
5 Citations

Short palate, lung, and nasal epithelial clone 1 has antimicrobial and antibiofilm activities against the Burkholderia cepacia complex

Ahmad, S., Tyrrell, J., Walton, W. G., Tripathy, A., Redinbo, M. R. & Tarran, R. Oct 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 10, p. 6003-6012 10 p.

Research output: Contribution to journalArticle

Burkholderia cepacia complex
Palate
Nose
Clone Cells
Lung
2015
21 Citations

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation

Zhao, H. , Ghirlando, R. , Alfonso, C. , Arisaka, F. , Attali, I. , Bain, D. L. , Bakhtina, M. M. , Becker, D. F. , Bedwell, G. J. , Bekdemir, A. , Besong, T. M. D. , Birck, C. , Brautigam, C. A. , Brennerman, W. , Byron, O. , Bzowska, A. , Chaires, J. B. , Chaton, C. T. , Cölfen, H. , Connaghan, K. D. & 30 others Crowley, K. A., Curth, U., Daviter, T., Dean, W. L., Díez, A. I., Ebel, C., Eckert, D. M., Eisele, L. E., Eisenstein, E., England, P., Escalante, C., Fagan, J. A., Fairman, R., Finn, R. M., Fischle, W., García De La Torre, J., Gor, J., Gustafsson, H., Hall, D., Harding, S. E., Hernández Cifre, J. G., Herr, A. B., Howell, E. E., Isaac, R. S., Jao, S. C., Jose, D., Kim, S. J., Kokona, B., Kornblatt, J. A. & Kosek, D. May 21 2015 In : PloS one. 10, 5, e0126420

Research output: Contribution to journalArticle

ultracentrifugation
Ultracentrifugation
Calibration
bovine serum albumin
Bovine Serum Albumin
4 Citations

Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display

Guntas, G., Lewis, S. M., Mulvaney, K. M., Cloer, E. W., Tripathy, A., Lane, T. R., Major, M. B. & Kuhlman, B. Sep 25 2015 In : Protein Engineering, Design and Selection. 29, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Bacteriophages
Oxidation-Reduction
Cysteine
Display devices
Proteins
2014
28 Citations

Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8

Ma, A., Yu, W., Li, F., Bleich, R. M., Herold, J. M., Butler, K. V., Norris, J. L., Korboukh, V., Tripathy, A., Janzen, W. P., Arrowsmith, C. H., Frye, S. V., Vedadi, M., Brown, P. J. & Jin, J. Aug 14 2014 In : Journal of Medicinal Chemistry. 57, 15, p. 6822-6833 12 p.

Research output: Contribution to journalArticle

Methyltransferases
Lysine
Proliferating Cell Nuclear Antigen
Biological Phenomena
Calorimetry
14 Citations

The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration

Choudhury, R., Roy, S. G., Tsai, Y. S., Tripathy, A., Graves, L. M. & Wang, Z. Jan 23 2014 In : Nature Communications. 5, 3078

Research output: Contribution to journalArticle

splicing
Mitogen-Activated Protein Kinase Kinases
Cell proliferation
Cell Movement
Cell Proliferation
2013
85 Citations

An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting

Cai, L., Rothbart, S. B., Lu, R., Xu, B., Chen, W. Y., Tripathy, A., Rockowitz, S., Zheng, D., Patel, D. J., Allis, C. D., Strahl, B. D., Song, J. & Wang, G. G. Feb 7 2013 In : Molecular Cell. 49, 3, p. 571-582 12 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Methylation
Chromatin
Proteins
Histones
10 Citations

Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): Structural and thermodynamic basis of CIB1 promiscuity

Freeman, T. C., Black, J. L., Bray, H. G., Dagliyan, O., Wu, Y. I., Tripathy, A., Dokholyan, N. V., Leisner, T. M. & Parise, L. V. Oct 8 2013 In : Biochemistry. 52, 40, p. 7082-7090 9 p.

Research output: Contribution to journalArticle

Calcium-Binding Proteins
Thermodynamics
Integrins
Carrier Proteins
Calcium
66 Citations

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

Garland, A. L., Walton, W. G., Coakley, R. D., Tan, C. D., Gilmore, R. C., Hobbs, C. A., Tripathy, A., Clunes, L. A., Bencharit, S., Stutts, M. J., Betts, L., Redinbo, M. R. & Tarran, R. Oct 1 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 15973-15978 6 p.

Research output: Contribution to journalArticle

Dehydration
Cystic Fibrosis
Epithelial Sodium Channels
Palate
Nose
18 Citations

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

Chopra, S., Palencia, A., Virus, C., Tripathy, A., Temple, B. R., Velazquez-Campoy, A., Cusack, S. & Reader, J. S. 2013 In : Nature Communications. 4, 1417

Research output: Contribution to journalArticle

Plant Tumors
Biocontrol
Amino Acyl-tRNA Synthetases
antibiotics
Transfer RNA
13 Citations

The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: Structural and single-molecule characterization

Rao, L., Romes, E. M., Nicholas, M. P., Brenner, S., Tripathy, A., Gennerich, A. & Slep, K. C. Aug 1 2013 In : Molecular Biology of the Cell. 24, 15, p. 2362-2377 16 p.

Research output: Contribution to journalArticle

Dyneins
Dimerization
Yeasts
Motor Activity
Tail
2012
16 Citations

Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction

Romes, E. M., Tripathy, A. & Slep, K. C. May 4 2012 In : Journal of Biological Chemistry. 287, 19, p. 15862-15873 12 p.

Research output: Contribution to journalArticle

Nuclear Pore
Dyneins
Yeast
Yeasts
Peptides
2011
259 Citations

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Vedadi, M. , Barsyte-Lovejoy, D. , Liu, F. , Rival-Gervier, S. , Allali-Hassani, A. , Labrie, V. , Wigle, T. J. , Dimaggio, P. A. , Wasney, G. A. , Siarheyeva, A. , Dong, A. , Tempel, W. , Wang, S. C. , Chen, X. , Chau, I. , Mangano, T. J. , Huang, X. P. , Simpson, C. D. , Pattenden, S. G. , Norris, J. L. & 12 others Kireev, D. B., Tripathy, A., Edwards, A., Roth, B. L., Janzen, W. P., Garcia, B. A., Petronis, A., Ellis, J., Brown, P. J., Frye, S. V., Arrowsmith, C. H. & Jin, J. Jan 1 2011 In : Nature Chemical Biology. 7, 8, p. 566-574 9 p.

Research output: Contribution to journalArticle

Methyltransferases
Histone-Lysine N-Methyltransferase
Genes
MCF-7 Cells
MicroRNAs
47 Citations

Computational design of a symmetric homodimer using β-strand assembly

Stranges, P. B., Machius, M., Miley, M. J., Tripathy, A. & Kuhlman, B. Dec 20 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20562-20567 6 p.

Research output: Contribution to journalArticle

Proteins
beta-Strand Protein Conformation
9 Citations

Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex

Carroll, M. J., Gromova, A. V., Miller, K. R., Tang, H., Wang, X. S., Tripathy, A., Singleton, S. F., Collins, E. J. & Lee, A. L. Apr 27 2011 In : Journal of the American Chemical Society. 133, 16, p. 6422-6428 7 p.

Research output: Contribution to journalArticle

Ligands
Proteins
Drug Substitution
Benchmarking
Tetrahydrofolate Dehydrogenase
2 Citations

Erratum: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells (Nature Chemical Biology (2011) 7 (401-404))

Vedadi, M. , Barsyte-Lovejoy, D. , Liu, F. , Rival-Gervier, S. , Allali-Hassani, A. , Labrie, V. , Wigle, T. J. , Dimaggio, P. A. , Wasney, G. A. , Siarheyeva, A. , Dong, A. , Tempel, W. , Wang, S. C. , Chen, X. , Chau, I. , Mangano, T. J. , Huang, X. P. , Simpson, C. D. , Pattenden, S. G. , Norris, J. L. & 12 others Kireev, D. B., Tripathy, A., Edwards, A., Roth, B. L., Janzen, W. P., Garcia, B. A., Petronis, A., Ellis, J., Brown, P. J., Frye, S. V., Arrowsmith, C. H. & Jin, J. Jan 1 2011 In : Nature Chemical Biology. 7, 9, 1 p.

Research output: Contribution to journalComment/debate

Methyltransferases
77 Citations

Small-molecule ligands of methyl-lysine binding proteins

Herold, J. M., Wigle, T. J., Norris, J. L., Lam, R., Korboukh, V. K., Gao, C., Ingerman, L. A., Kireev, D. B., Senisterra, G., Vedadi, M., Tripathy, A., Brown, P. J., Arrowsmith, C. H., Jin, J., Janzen, W. P. & Frye, S. V. Apr 14 2011 In : Journal of Medicinal Chemistry. 54, 7, p. 2504-2511 8 p.

Research output: Contribution to journalArticle

Lysine
Carrier Proteins
Histones
Ligands
Peptides
6 Citations

Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization

Lomino, J. V., Tripathy, A. & Redinbo, M. R. May 2011 In : Journal of Bacteriology. 193, 9, p. 2089-2096 8 p.

Research output: Contribution to journalArticle

Dimerization
Mycobacterium tuberculosis
Heparitin Sulfate
Ultracentrifugation
Circular Dichroism
2010
25 Citations

Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes

Haque, M. E., Elmore, K. B., Tripathy, A., Koc, H., Koc, E. C. & Spremulli, L. L. Sep 3 2010 In : Journal of Biological Chemistry. 285, 36, p. 28353-28362 10 p.

Research output: Contribution to journalArticle

Ribosomal Proteins
Bacterial Large Ribosome Subunits
Tail
Membrane Proteins
Membranes
2009
7 Citations

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels

Meissner, G., Pasek, D. A., Yamaguchi, N., Ramachandran, S., Dokholyan, N. V. & Tripathy, A. Jan 2009 In : Proteins: Structure, Function and Bioinformatics. 74, 1, p. 207-211 5 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Calmodulin
Ion Channels
Thermodynamics
Muscle
2007
18 Citations

Role of 'B-b' knob-hole interactions in fibrin binding to adsorbed fibrinogen

Geer, C. B., Tripathy, A., Schoenfisch, M. H., Lord, S. T. & Gorkun, O. V. Dec 2007 In : Journal of Thrombosis and Haemostasis. 5, 12, p. 2344-2351 8 p.

Research output: Contribution to journalArticle

Fibrin
Fibrinogen
glycyl-histidyl-arginyl-proline
Polymerization
glycyl-prolyl-arginyl-proline
18 Citations

Solution structure of polymerase μ's BRCT domain reveals an element essential for its role in nonhomologous end joining

DeRose, E. F., Clarkson, M. W., Gilmore, S. A., Galban, C. J., Tripathy, A., Havener, J. M., Mueller, G. A., Ramsden, D. A., London, R. E. & Lee, A. L. Oct 30 2007 In : Biochemistry. 46, 43, p. 12100-12110 11 p.

Research output: Contribution to journalArticle

Joining
Chromosome Breakage
Proteins
DNA polymerase mu
Structural dynamics
46 Citations

The Structure of the Coiled-Coil Domain of Ndel1 and the Basis of Its Interaction with Lis1, the Causal Protein of Miller-Dieker Lissencephaly

Derewenda, U., Tarricone, C., Choi, W. C., Cooper, D. R., Lukasik, S., Perrina, F., Tripathy, A., Kim, M. H., Cafiso, D. S., Musacchio, A. & Derewenda, Z. S. Nov 13 2007 In : Structure. 15, 11, p. 1467-1481 15 p.

Research output: Contribution to journalArticle

Classical Lissencephalies and Subcortical Band Heterotopias
Physiological Phenomena
Dyneins
Microtubules
X-Ray Diffraction
2006
39 Citations

Human PXR forms a tryptophan zipper-mediated homodimer

Noble, S. M., Carnahan, V. E., Moore, L. B., Luntz, T., Wang, H., Ittoop, O. R., Stimmel, J. B., Davis-Searles, P. R., Watkins, R. E., Wisely, G. B., LeCluyse, E., Tripathy, A., McDonnell, D. P. & Redinbo, M. R. Jul 18 2006 In : Biochemistry. 45, 28, p. 8579-8589 11 p.

Research output: Contribution to journalArticle

Fasteners
Tryptophan
Cytoplasmic and Nuclear Receptors
Ligands
Xenobiotics
7 Citations

Pressure perturbation calorimetry of helical peptides

Barrett, D. G., Minder, C. M., Mian, M. U., Whittington, S. J., Cooper, W. J., Fuchs, K. M., Tripathy, A., Waters, M. L., Creamer, T. P. & Pielak, G. J. May 1 2006 In : Proteins: Structure, Function and Genetics. 63, 2, p. 322-326 5 p.

Research output: Contribution to journalArticle

Calorimetry
Pressure
Peptides
Dichroism
Circular Dichroism
37 Citations

Temperature-induced reversible conformational change in the first 100 residues of α-synuclein

Mcnulty, B. C., Tripathy, A., Young, G. B., Charlton, L. M., Orans, J. & Pielak, G. J. Mar 2006 In : Protein Science. 15, 3, p. 602-608 7 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Temperature
Proteins
Lewy Bodies
Springs (water)
2005

Erratum: Dictyostelium myosin bipolar thick filament formation: Importance of charge and specific domains of the myosin rod (Plos Biology (2005) 2:11 DOI: 10.1371/journal.pbio.0030119)

Hostetter, D., Rice, S., Dean, S., Altman, D., McMahon, P. M., Sutton, S., Tripathy, A. & Spudich, J. A. Mar 1 2005 In : PLoS Biology. 3, 3, 1 p.

Research output: Contribution to journalComment/debate

Nanoparticles
134 Citations

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

Ortlund, E. A., Lee, Y., Solomon, I. H., Hager, J. M., Safi, R., Choi, Y., Guan, Z., Tripathy, A., Raetz, C. R. H., McDonnell, D. P., Moore, D. D. & Redinbo, M. R. Dec 1 2005 In : Nature Structural and Molecular Biology. 12, 4, p. 357-363 7 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Phospholipids
Liver
Ligands
Furylfuramide
2004
21 Citations

Dictyostelium myosin bipolar thick filament formation: Importance of charge and specific domains of the myosin rod

Hostetter, D., Rice, S., Dean, S., Altman, D., McMahon, P. M., Sutton, S., Tripathy, A. & Spudich, J. A. Nov 1 2004 In : PLoS Biology. 2, 11

Research output: Contribution to journalArticle

Myosin Type II
Myosin Subfragments
Dictyostelium
Myosins
myosin
237 Citations

Impact of Protein Denaturants and Stabilizers on Water Structure

Batchelor, J. D., Olteanu, A., Tripathy, A. & Pielak, G. J. Feb 25 2004 In : Journal of the American Chemical Society. 126, 7, p. 1958-1961 4 p.

Research output: Contribution to journalArticle

Proteins
Water
Protein Stability
Calorimetry
Partial Pressure
15 Citations

Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3

Feeney, B., Pop, C., Tripathy, A. & Clark, A. C. Dec 15 2004 In : Biochemical Journal. 384, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

Caspase 3
Dimers
Catalytic Domain
Mutation
Caspases
2003
28 Citations

Mutations in the Procaspase-3 Dimer Interface Affect the Activity of the Zymogen

Pop, C., Feeney, B., Tripathy, A. & Clark, A. C. Oct 28 2003 In : Biochemistry. 42, 42, p. 12311-12320 10 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Caspase 3
Dimers
Mutation
Catalytic Domain
2002
32 Citations

Effects of molecular crowding by saccharides on α-chymotrypsin dimerization

Patel, C. N., Noble, S. M., Weatherly, G. T., Tripathy, A., Winzor, D. J. & Pielak, G. J. 2002 In : Protein Science. 11, 5, p. 997-1003 7 p.

Research output: Contribution to journalArticle

Crowding
Dimerization
Stabilization
Energy Transfer
Physical Chemistry
2001
25 Citations

A novel fluorescence assay to study propeptide interaction with γ-glutamyl carboxylase

Presnell, S. R., Tripathy, A., Lentz, B. R. & Stafford, D. W. Oct 2 2001 In : Biochemistry. 40, 39, p. 11723-11733 11 p.

Research output: Contribution to journalArticle

Assays
Fluorescence
Fluorescein
Carboxylation
Substrates
55 Citations

Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer

Pop, C., Chen, Y. R., Smith, B., Bose, K., Bobay, B., Tripathy, A., Franzen, S. & Clark, A. C. Nov 27 2001 In : Biochemistry. 40, 47, p. 14224-14235 12 p.

Research output: Contribution to journalArticle

Caspase 3
Dimers
Conformations
Peptides
Fluorescence Polarization
83 Citations

TgM2AP participates in toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2

Rabenau, K. E., Sohrabi, A., Tripathy, A., Reitter, C., Ajioka, J. W., Tomley, F. M. & Carruthers, V. B. 2001 In : Molecular Microbiology. 41, 3, p. 537-547 11 p.

Research output: Contribution to journalArticle

Toxoplasma
Adhesives
Parasites
Proteins
Eimeria tenella
32 Citations

Two domains in dihydropyridine receptor activate the skeletal muscle Ca2+ release channel

Stange, M., Tripathy, A. & Meissner, G. Jan 1 2001 In : Biophysical Journal. 81, 3, p. 1419-1429 11 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
Skeletal Muscle
Peptides
Excitation Contraction Coupling
Ryanodine
2000
108 Citations

Evidence for a role of the lumenal M3-M4 loop in skeletal muscle Ca2+ release channel (ryanodine receptor) activity and conductance

Gao, L., Balshaw, D., Xu, L., Tripathy, A., Xin, C. & Meissner, G. Jan 1 2000 In : Biophysical Journal. 79, 2, p. 828-840 13 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Ryanodine
Skeletal Muscle
Caffeine
Amino Acids
1999
21 Citations
Ryanodine Receptor Calcium Release Channel
Myocardium
Skeletal Muscle
Ryanodine
Sarcoplasmic Reticulum
80 Citations
Ruthenium Red
Ryanodine Receptor Calcium Release Channel
Muscle
Myocardium
Skeletal Muscle
56 Citations

Selectivity and permeation in calcium release channel of cardiac muscle: Alkali metal ions

Chen, D. P., Xu, L., Tripathy, A., Meissner, G. & Eisenberg, B. Jan 1 1999 In : Biophysical Journal. 76, 3, p. 1346-1366 21 p.

Research output: Contribution to journalArticle

Alkali Metals
Calcium Channels
Myocardium
Ions
Permeability
1998
5 Citations

A study of reconstituted anion channels using lipid bilayers

Tripathy, A., Tien, H. T. & Ottova, A. L. Jan 1 1998 In : Bioelectrochemistry and Bioenergetics. 44, 2, p. 183-199 17 p.

Research output: Contribution to journalArticle

Chloride Channels
Lipid bilayers
Lipid Bilayers
Sarcoplasmic Reticulum
Anions
69 Citations

Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle

Tripathy, A., Resch, W., Xu, L. E., Valdivia, H. H. & Meissner, G. May 1998 In : Journal of General Physiology. 111, 5, p. 679-690 12 p.

Research output: Contribution to journalArticle

Ryanodine
Ryanodine Receptor Calcium Release Channel
Myocardium
Skeletal Muscle
Binding Sites
88 Citations

Potential for pharmacology of ryanodine receptor/calcium release channels

Xu, L. E., Tripathy, A., Pasek, D. A. & Meissner, G. 1998 In : Annals of the New York Academy of Sciences. 853, p. 130-148 19 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Pharmacology
Muscle
Purinergic Antagonists
Purinergic Agonists
1997
48 Citations

Evidence for a role of C-terminal amino acid residues in skeletal muscle Ca2+ release channel (ryanodine receptor) function

Gao, L., Tripathy, A., Lu, X. & Meissner, G. Jul 21 1997 In : FEBS Letters. 412, 1, p. 223-226 4 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Muscle
Skeletal Muscle
Amino Acids
Ryanodine
51 Citations

Permeation through the calcium release channel of cardiac muscle

Chen, D., Xu, L., Tripathy, A., Meissner, G. & Eisenberg, B. Jan 1 1997 In : Biophysical Journal. 73, 3, p. 1337-1354 18 p.

Research output: Contribution to journalArticle

Calcium Channels
Myocardium
Sarcoplasmic Reticulum
Ions
117 Citations

Regulation of skeletal muscle Ca2+ release channel (ryanodine receptor) by Ca2+ and monovalent cations and anions

Meissner, G., Rios, E., Tripathy, A. & Pasek, D. A. 1997 In : Journal of Biological Chemistry. 272, 3, p. 1628-1638 11 p.

Research output: Contribution to journalArticle

Monovalent Cations
Ryanodine
Ryanodine Receptor Calcium Release Channel
Anions
Muscle
1996
144 Citations
Sarcoplasmic Reticulum
Skeletal Muscle
Adenosine Triphosphate
Ryanodine Receptor Calcium Release Channel
Divalent Cations
1995
227 Citations

Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor)

Tripathy, A., Xu, L., Mann, G. & Meissner, G. Jan 1 1995 In : Biophysical Journal. 69, 1, p. 106-119 14 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Calmodulin
Skeletal Muscle
Sarcoplasmic Reticulum
Ryanodine
1989
Optical losses