• 1922 Citations
  • 24 h-Index
1976 …2018
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  • 15 Similar Profiles
Cystic Fibrosis Transmembrane Conductance Regulator Medicine & Life Sciences
Nucleotides Medicine & Life Sciences
Cystic Fibrosis Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Genetic Transcription Medicine & Life Sciences
Ion Channel Gating Medicine & Life Sciences
Chloride Channels Medicine & Life Sciences
Phosphorylation Chemical Compounds

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Projects 1996 2017

Research Output 1976 2018

  • 1922 Citations
  • 24 h-Index
  • 62 Article
  • 2 Comment/debate
  • 2 Review article

Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel

Fay, J. F., Aleksandrov, L. A., Jensen, T. J., Cui, L. L., Kousouros, J. N., He, L., Aleksandrov, A. A., Gingerich, D. S., Riordan, J. R. & Chen, J. Z., Oct 30 2018, In : Biochemistry. 57, 43, p. 6234-6246 13 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Phosphorylation
Adenosinetriphosphate
Medical imaging
Diagnostic Imaging
1 Citations

Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1

Yang, Z., Hildebrandt, E., Jiang, F., Aleksandrov, A. A., Khazanov, N., Zhou, Q., An, J., Mezzell, A. T., Xavier, B. M., Ding, H., Riordan, J. R., Senderowitz, H., Kappes, J. C., Brouillette, C. G. & Urbatsch, I. L., May 1 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 5, p. 1193-1204 12 p.

Research output: Contribution to journalArticle

Protein Interaction Domains and Motifs
Cystic Fibrosis Transmembrane Conductance Regulator
ATP-Binding Cassette Transporters
Adenosine Triphosphatases
Animals
6 Citations

Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations

Vernon, R. M., Chong, P. A., Lin, H., Yang, Z., Zhou, Q., Aleksandrov, A. A., Dawson, J. E., Riordan, J. R., Brouillette, C. G., Thibodeau, P. H. & Forman-Kay, J. D., Aug 25 2017, In : Journal of Biological Chemistry. 292, 34, p. 14147-14164 18 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Stabilization
Mutation
Substitution reactions
5 Citations

Transmembrane helical interactions in the CFTR channel pore

Das, J., Aleksandrov, A. A., Cui, L., He, L., Riordan, J. R. & Dokholyan, N. V., Jun 1 2017, In : PLoS Computational Biology. 13, 6, e1005594.

Research output: Contribution to journalArticle

Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
cystic fibrosis
Conductance
Regulator
10 Citations

A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface

Hildebrandt, E., Ding, H., Mulky, A., Dai, Q., Aleksandrov, A. A., Bajrami, B., Diego, P. A., Wu, X., Ray, M., Naren, A. P., Riordan, J. R., Yao, X., DeLucas, L. J., Urbatsch, I. L. & Kappes, J. C., May 1 2015, In : Molecular Biotechnology. 57, 5, p. 391-405 15 p.

Research output: Contribution to journalArticle

Recombinant proteins
Cystic Fibrosis Transmembrane Conductance Regulator
Recombinant Proteins
Cystic Fibrosis
Cell membranes