• 1948 Citations
  • 24 h-Index
1976 …2018
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  • 14 Similar Profiles
Cystic Fibrosis Transmembrane Conductance Regulator Medicine & Life Sciences
Nucleotides Medicine & Life Sciences
Cystic Fibrosis Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Genetic Transcription Medicine & Life Sciences
Ion Channel Gating Medicine & Life Sciences
Mutation Medicine & Life Sciences
Chloride Channels Medicine & Life Sciences

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Projects 1996 2017

Research Output 1976 2018

  • 1948 Citations
  • 24 h-Index
  • 64 Article
  • 2 Comment/debate
  • 2 Review article
1 Citations

Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel

Fay, J. F., Aleksandrov, L. A., Jensen, T. J., Cui, L. L., Kousouros, J. N., He, L., Aleksandrov, A. A., Gingerich, D. S., Riordan, J. R. & Chen, J. Z., Oct 30 2018, In : Biochemistry. 57, 43, p. 6234-6246 13 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Anions
Visualization
Adenosine Triphosphate
Phosphorylation

Increases in cytosolic Ca2+ induce dynamin- and calcineurin-dependent internalisation of CFTR

Patel, W., Moore, P. J., Sassano, M. F., Lopes-Pacheco, M., Aleksandrov, A. A., Amaral, M. D., Tarran, R. & Gray, M. A., Jan 1 2018, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

Dynamins
Cystic Fibrosis Transmembrane Conductance Regulator
Calcineurin
Cell Membrane
Smoke

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator

Wang, C., Aleksandrov, A. A., Yang, Z., Forouhar, F., Proctor, E. A., Kota, P., An, J., Kaplan, A., Khazanov, N., Boël, G., Stockwell, B. R., Senderowitz, H., Dokholyan, N. V., Riordan, J. R., Brouillette, C. G. & Hunt, J. F., Jan 1 2018, In : Journal of Biological Chemistry. 293, 46, p. 17685-17704 20 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Ligands
Mutation
Nucleotides
Molecules
1 Citations

Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1

Yang, Z., Hildebrandt, E., Jiang, F., Aleksandrov, A. A., Khazanov, N., Zhou, Q., An, J., Mezzell, A. T., Xavier, B. M., Ding, H., Riordan, J. R., Senderowitz, H., Kappes, J. C., Brouillette, C. G. & Urbatsch, I. L., May 1 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 5, p. 1193-1204 12 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Mutation
Hot Temperature
Chloride Channels
6 Citations

Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations

Vernon, R. M., Chong, P. A., Lin, H., Yang, Z., Zhou, Q., Aleksandrov, A. A., Dawson, J. E., Riordan, J. R., Brouillette, C. G., Thibodeau, P. H. & Forman-Kay, J. D., Aug 25 2017, In : Journal of Biological Chemistry. 292, 34, p. 14147-14164 18 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Stabilization
Mutation
Substitution reactions