Research Output 1978 2018

2018

Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence

Bohnsack, J. P., Hughes, B. A., O'Buckley, T. K., Edokpolor, K., Besheer, J. & Morrow, A. L. Jun 1 2018 In : Neuropsychopharmacology. 43, 7, p. 1518-1529 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Alcoholism
Ethanol
trichostatin A
Substance Withdrawal Syndrome
Pregnanolone
Absorption refrigeration
Macaca fascicularis
Chemokine CCL2
Adders
2017
3 Citations
Desoxycorticosterone
Self Administration
Macaca fascicularis
Ethanol
Appointments and Schedules
1 Citations
Ventral Tegmental Area
Brain
Steroids
Alcohols
Substantia Nigra
3 Citations

Ethanol exposure regulates Gabra1 Expression via histone deacetylation at the promoter in cultured cortical neurons

Bohnsack, J. P., Patel, V. K. & Morrow, A. L. Jan 1 2017 In : Journal of Pharmacology and Experimental Therapeutics. 363, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Gene Knockdown Techniques
Histone Deacetylase Inhibitors
Gene Expression Regulation
GABA-A Receptors

Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains

Porcu, P., O'Buckley, T. K., Lopez, M. F., Becker, H. C., Miles, M. F., Williams, R. W. & Morrow, A. L. Feb 1 2017 In : Alcohol. 58, p. 107-125 19 p.

Research output: Contribution to journalArticle

Dissection
Ethanol
Steroids
air
anxiety
3 Citations

Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) in the amygdala of the cynomolgus monkey

Beattie, M. C., Maldonado-Devincci, A. M., Porcu, P., O'Buckley, T. K., Daunais, J. B., Grant, K. A. & Morrow, A. L. Mar 1 2017 In : Addiction Biology. 22, 2, p. 318-330 13 p.

Research output: Contribution to journalArticle

Pregnanolone
Macaca fascicularis
Amygdala
Ethanol
Steroids
2016
12 Citations

5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

Martinez, P. E., Rubinow, D. R., Nieman, L. K., Koziol, D. E., Morrow, A. L., Schiller, C. E., Cintron, D., Thompson, K. D., Khine, K. K. & Schmidt, P. J. Mar 1 2016 In : Neuropsychopharmacology. 41, 4, p. 1093-1102 10 p.

Research output: Contribution to journalArticle

Pregnanolone
Luteal Phase
Oxidoreductases
Neurotransmitter Agents
Placebos
7 Citations

Blunted neuroactive steroid and HPA axis responses to stress are associated with reduced sleep quality and negative affect in pregnancy: A pilot study

Crowley, S. K., O'Buckley, T. K., Schiller, C. E., Stuebe, A., Morrow, A. L. & Girdler, S. S. Apr 1 2016 In : Psychopharmacology. 233, 7, p. 1299-1310 12 p.

Research output: Contribution to journalArticle

Pregnanolone
Hydrocortisone
Sleep
Steroids
Progesterone
1 Citations

Chronic intermittent ethanol exposure alters stress effects on (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) immunolabeling of Amygdala neurons in C57BL/6J mice

Maldonado-Devincci, A. M., Kampov-Polevoi, A., McKinley, R. E., Morrow, D. H., O’Buckley, T. K. & Morrow, A. L. Mar 4 2016 In : Frontiers in Cellular Neuroscience. 10, MAR2016, 40

Research output: Contribution to journalArticle

Amygdala
Inbred C57BL Mouse
Ethanol
Neurons
Brain
10 Citations
GABA-A Receptors
Cyclic AMP-Dependent Protein Kinases
gamma-Aminobutyric Acid
Protein Kinase C
Neurons
2 Citations

Editorial: Reporting guidelines for psychopharmacology

Steckler, T., Curran, H. V., De Wit, H., Howes, O., Hoyer, D., Lucki, I., Miczek, K. A., Morrow, A. L., Price, L. H. & Robbins, T. W. Apr 1 2016 In : Psychopharmacology. 233, 7, p. 1131-1134 4 p.

Research output: Contribution to journalReview article

5 Citations

Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids

Werner, D. F., Porcu, P., Boyd, K. N., O'Buckley, T. K., Carter, J. M., Kumar, S. & Morrow, A. L. Apr 1 2016 In : Molecular and Cellular Neuroscience. 72, p. 1-8 8 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Ethanol
Steroids
Phosphorylation
Finasteride
8 Citations

Ethanol regulation of synaptic GABAA α4 receptors is prevented by protein kinase A activation

Carlson, S. L., Bohnsack, J. P. & Morrow, A. L. Apr 1 2016 In : Journal of Pharmacology and Experimental Therapeutics. 357, 1, p. 10-16 7 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
gamma-Aminobutyric Acid
Ethanol
Protein Kinase C
Rolipram
26 Citations

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

Porcu, P., Barron, A. M., Frye, C. A., Walf, A. A., Yang, S. Y., He, X. Y., Morrow, A. L., Panzica, G. C. & Melcangi, R. C. Feb 1 2016 In : Journal of neuroendocrinology. 28, 2, p. 1-19 19 p.

Research output: Contribution to journalReview article

Translational Medical Research
Steroids
Neurodegenerative Diseases
Pregnanes
Steroid Receptors
11 Citations
Enzyme Activators
GABA Antagonists
Phorbol 12,13-Dibutyrate
Isoxazoles
Enzyme Activation

The Effects of Acute and Chronic Ethanol Exposure on GABAergic Neuroactive Steroid Immunohistochemistry: Relationship to Ethanol Drinking

Beattie, M. C., Maldonado-Devincci, A., Cook, J. B. & Leslie Morrow, A. Mar 23 2016 Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Elsevier Inc., Vol. 1, p. 433-444 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drinking
Ethanol
Immunohistochemistry
Steroids
Animal Models
2015
18 Citations

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala

Pleil, K. E., Lowery-Gionta, E. G., Crowley, N. A., Li, C., Marcinkiewcz, C. A., Rose, J. H., McCall, N. M., Maldonado-Devincci, A. M., Morrow, A. L., Jones, S. R. & Kash, T. L. Dec 1 2015 In : Neuropharmacology. 99, p. 735-749 15 p.

Research output: Contribution to journalArticle

Amygdala
Prefrontal Cortex
Ethanol
Anxiety
Calcium Carbonate
2014
8 Citations

Altered GABAa receptor expression and seizure threshold following acute ethanol challenge in mice lacking the RIIβ subunit of PKA

Carlson, S. L., O'Buckley, T. K., Thomas, R., Thiele, T. E. & Morrow, A. L. Jan 1 2014 In : Neurochemical Research. 39, 6, p. 1079-1087 9 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Seizures
gamma-Aminobutyric Acid
Ethanol
Bicuculline
12 Citations

Chronic Intermittent Ethanol Exposure and Withdrawal Alters (3α,5α)-3-Hydroxy-Pregnan-20-One Immunostaining in Cortical and Limbic Brain Regions of C57BL/6J Mice

Maldonado-Devincci, A. M., Cook, J. B., O'Buckley, T. K., Morrow, D. H., Mckinley, R. E., Lopez, M. F., Becker, H. C. & Morrow, A. L. Oct 1 2014 In : Alcoholism: Clinical and Experimental Research. 38, 10, p. 2561-2571 11 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Brain
Ethanol
Drinking
Hippocampal CA3 Region
13 Citations

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: Relevance for human studies

Porcu, P. & Morrow, A. L. Sep 1 2014 In : Psychopharmacology. 231, 17, p. 3257-3272 16 p.

Research output: Contribution to journalReview article

Ethanol
Steroids
Physiological Phenomena
GABA Receptors
Menstrual Cycle
5 Citations

Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J Mice

Fish, E. W., Whitman, B. J., Diberto, J. F., Robinson, J. E., Morrow, A. L. & Malanga, C. J. Sep 1 2014 In : Psychopharmacology. 231, 17, p. 3415-3423 9 p.

Research output: Contribution to journalArticle

Pregnanolone
Self Stimulation
Reward
Inbred C57BL Mouse
Steroids
24 Citations

Ethanol Administration Produces Divergent Changes in GABAergic Neuroactive Steroid Immunohistochemistry in the Rat Brain

Cook, J. B., Dumitru, A. M. G., O'Buckley, T. K. & Morrow, A. L. Jan 2014 In : Alcoholism: Clinical and Experimental Research. 38, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

Rats
Brain
Ethanol
Immunohistochemistry
Steroids
7 Citations

Ethanol alters local cellular levels of (3α,5α)-3- hydroxypregnan-20-one (3α,5α-THP) independent of the adrenals in subcortical brain regions

Cook, J. B., Nelli, S. M., Neighbors, M. R., Morrow, D. H., O'Buckley, T. K., Maldonado-Devincci, A. M. & Morrow, A. L. Jan 1 2014 In : Neuropsychopharmacology. 39, 8, p. 1978-1987 10 p.

Research output: Contribution to journalArticle

Pregnanolone
Ethanol
Brain
Adrenal Glands
Prefrontal Cortex
9 Citations

Failure of Acute Ethanol Administration to Alter Cerebrocortical and Hippocampal Allopregnanolone Levels in C57BL/6J and DBA/2J Mice

Porcu, P., Locci, A., Santoru, F., Berretti, R., Morrow, A. L. & Concas, A. 2014 In : Alcoholism: Clinical and Experimental Research. 38, 4, p. 948-958 11 p.

Research output: Contribution to journalArticle

Pregnanolone
Inbred DBA Mouse
Corticosterone
Ethanol
Progesterone
12 Citations

Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α, 5α-THP and reduces long-term operant ethanol self-administration

Cook, J. B., Werner, D. F., Maldonado-Devincci, A. M., Leonard, M. N., Fisher, K. R., O'Buckley, T. K., Porcu, P., McCown, T. J., Besheer, J., Hodge, C. W. & Leslie Morrow, A. 2014 In : Journal of Neuroscience. 34, 17, p. 5824-5834 11 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Self Administration
Cytochrome P-450 Enzyme System
Ethanol
Nucleus Accumbens
5 Citations

Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice

Maldonado-Devincci, A. M., Beattie, M. C., Morrow, D. H., McKinley, R. E., Cook, J. B., O'Buckley, T. K. & Morrow, A. L. Sep 1 2014 In : Psychopharmacology. 231, 17, p. 3281-3292 12 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Vesicular Glutamate Transport Protein 1
Nucleus Accumbens
Brain
Steroids

Special issue in memory of Robert H. Purdy

Morrow, A. L. Sep 1 2014 In : Psychopharmacology. 231, 17, p. 3241-3242 2 p.

Research output: Contribution to journalEditorial

21st Century History
20th Century History
Psychopharmacology
Neurotransmitter Agents
2013
16 Citations

Ethanol activation of protein kinase a regulates GABAA α1 receptor function and trafficking in cultured cerebral Cortical Neurons

Carlson, S. L., Kumar, S., Werner, D. F., Comerford, C. E. & Morrow, A. L. May 1 2013 In : Journal of Pharmacology and Experimental Therapeutics. 345, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
gamma-Aminobutyric Acid
Protein Kinases
Ethanol
Neurons
2012
29 Citations

A history of depression in women is associated with an altered GABAergic neuroactive steroid profile

Girdler, S. S., Lindgren, M., Porcu, P., Rubinow, D. R., Johnson, J. L. & Morrow, A. L. Apr 1 2012 In : Psychoneuroendocrinology. 37, 4, p. 543-553 11 p.

Research output: Contribution to journalArticle

Progesterone
Steroids
Depression
Dehydroepiandrosterone
Pregnenolone
18 Citations

Ethanol activation of protein kinase A regulates GABA A receptor subunit expression in the cerebral cortex and contributes to ethanol-induced hypnosis

Kumar, S., Ren, Q., Beckley, J. H., O'Buckley, T. K., Gigante, E. D., Santerre, J. L., Werner, D. F. & Morrow, A. L. Jun 18 2012 In : Frontiers in Neuroscience. APR, Article 44

Research output: Contribution to journalArticle

Hypnosis
Cyclic AMP-Dependent Protein Kinases
Cerebral Cortex
gamma-Aminobutyric Acid
Ethanol
2011
8 Citations

Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: Identification of QTLs and downstream gene regulation

Porcu, P., O'Buckley, T. K., Song, S. C., Harenza, J. L., Lu, L., Wang, X., Williams, R. W., Miles, M. F. & Morrow, A. L. 2011 In : PLoS One. 6, 4, e18405

Research output: Contribution to journalArticle

desoxycorticosterone
Desoxycorticosterone
Gene expression
Neurotransmitter Agents
genetic techniques and protocols
35 Citations

PKCγ is required for ethanol-induced increases in GABAA receptor α4 subunit expression in cultured cerebral cortical neurons

Werner, D. F., Kumar, S., Criswell, H. E., Suryanarayanan, A., Fetzer, J. A., Comerford, C. E. & Morrow, A. L. Feb 1 2011 In : Journal of Neurochemistry. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Neurons
Ethanol
Protein Kinase C
Biotinylation
2010
10 Citations

A putative 'pre-nervous' endocannabinoid system in early echinoderm development

Buznikov, G. A., Nikitina, L. A., Bezuglov, V. V., Francisco, M. E. Y., Boysen, G., Obispo-Peak, I. N., Peterson, R. E., Weiss, E. R., Schuel, H., Temple, B. R. S., Morrow, A. L. & Lauder, J. M. Mar 1 2010 In : Developmental Neuroscience. 32, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

Endocannabinoids
Nervous System
Sea Urchins
Vasopressin Receptors
Membrane Potentials
15 Citations

Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: Mechanisms and reversal by exogenous ACTH

Boyd, K. N., Kumar, S., O'Buckley, T. K. & Morrow, A. L. Jan 1 2010 In : Journal of Neurochemistry. 115, 1, p. 142-152 11 p.

Research output: Contribution to journalArticle

Adrenocorticotropic Hormone
Ethanol
Steroids
Progesterone
Rats
39 Citations

Differential effects of ethanol on serum GABAergic 3α,5α/ 3α,5β neuroactive steroids in mice, rats, cynomolgus monkeys, and humans

Porcu, P., O'Buckley, T. K., Alward, S. E., Song, S. C., Grant, K. A., De Wit, H. & Leslie Morrow, A. Mar 2010 In : Alcoholism: Clinical and Experimental Research. 34, 3, p. 432-442 11 p.

Research output: Contribution to journalArticle

Macaca fascicularis
Rats
Ethanol
Steroids
Serum
29 Citations

Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis

Boyd, K. N., Kumar, S., O'Buckley, T. K., Porcu, P. & Morrow, A. L. Feb 2010 In : Journal of Neurochemistry. 112, 3, p. 784-796 13 p.

Research output: Contribution to journalArticle

Pituitary Hormones
Adrenocorticotropic Hormone
Rats
Brain
Ethanol
33 Citations

Ethanol reduces GABAA α1 subunit receptor surface expression by a protein kinase Cγ-dependent mechanism in cultured cerebral cortical neurons

Kumar, S., Suryanarayanan, A., Boyd, K. N., Comerford, C. E., Lai, M. A., Ren, Q. & Morrow, A. L. May 2010 In : Molecular Pharmacology. 77, 5, p. 793-803 11 p.

Research output: Contribution to journalArticle

Protein Kinases
Ethanol
Neurons
gamma-Aminobutyric Acid
Protein Kinase C
15 Citations

Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the ASP40 allele of the OPRM1 gene: A pilot investigation

Ray, L. A., Hutchison, K. E., Ashenhurst, J. R. & Morrow, A. L. Aug 2010 In : Alcoholism: Clinical and Experimental Research. 34, 8, p. 1479-1482 4 p.

Research output: Contribution to journalArticle

Naltrexone
Pregnanolone
Genes
Alleles
Steroids
29 Citations

Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring P rats

Besheer, J., Lindsay, T. G., O'Buckley, T. K., Hodge, C. W. & Morrow, A. L. Dec 2010 In : Alcoholism: Clinical and Experimental Research. 34, 12, p. 2044-2052 9 p.

Research output: Contribution to journalArticle

Pregnenolone
Self Administration
Rats
Ethanol
Alcohols
2009
56 Citations

Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia

Maldonado-Avilés, J. G., Curley, A. A., Hashimoto, T., Morrow, A. L., Ramsey, A. J., O'Donnell, P., Volk, D. W. & Lewis, D. A. Apr 2009 In : American Journal of Psychiatry. 166, 4, p. 450-459 10 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
gamma-Aminobutyric Acid
Schizophrenia
Messenger RNA
delta Opioid Receptor
107 Citations

Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia

Marx, C. E., Keefe, R. S. E., Buchanan, R. W., Hamer, R. M., Kilts, J. D., Bradford, D. W., Strauss, J. L., Naylor, J. C., Payne, V. M., Lieberman, J. A., Savitz, A. J., Leimone, L. A., Dunn, L., Porcu, P., Morrow, A. L. & Shampine, L. J. Jul 1 2009 In : Neuropsychopharmacology. 34, 8, p. 1885-1903 19 p.

Research output: Contribution to journalArticle

Pregnenolone
Neurobehavioral Manifestations
Neurotransmitter Agents
Schizophrenia
Placebos
45 Citations

Simultaneous quantification of GABAergic 3α,5α/3α,5β neuroactive steroids in human and rat serum

Porcu, P., O'Buckley, T. K., Alward, S. E., Marx, C. E., Shampine, L. J., Girdler, S. S. & Morrow, A. L. Apr 1 2009 In : Steroids. 74, 4-5, p. 463-473 11 p.

Research output: Contribution to journalArticle

Rats
Steroids
Progesterone
Pregnanolone
Pregnenolone
18 Citations
Synaptic Transmission
gamma-Aminobutyric Acid
Neurons
Ethanol
Inhibitory Postsynaptic Potentials
245 Citations

The role of GABAA receptors in the acute and chronic effects of ethanol: A decade of progress

Kumar, S., Porcu, P., Werner, D. F., Matthews, D. B., Diaz-Granados, J. L., Helfand, R. S. & Morrow, A. L. Sep 2009 In : Psychopharmacology. 205, 4, p. 529-564 36 p.

Research output: Contribution to journalReview article

gamma-Aminobutyric Acid
Ethanol
Drinking
Synaptic Transmission
Alcoholism
19 Citations

The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008

Morrow, A. L., Biggio, G., Serra, M., Becker, H. C., Lopez, M. F., Porcu, P., Alward, S. E. & O'Buckley, T. K. Nov 1 2009 In : Alcohol. 43, 7, p. 521-530 10 p.

Research output: Contribution to journalReview article

Ethanol
Steroids
alcohol
Alcohols
interaction
2008
13 Citations

Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice

Matthews, D. B., Morrow, A. L., O'Buckley, T., Flanigan, T. J., Berry, R. B., Cook, M. N., Mittleman, G., Goldowitz, D., Tokunaga, S. & Silvers, J. M. Sep 1 2008 In : Alcohol. 42, 6, p. 469-476 8 p.

Research output: Contribution to journalArticle

Inbred DBA Mouse
Corticosterone
Drinking
Ethanol
Plasmas
17 Citations
Desoxycorticosterone
Steroids
Alcohols
Cosyntropin
Dexamethasone
9 Citations

Role of acetaldehyde in ethanol-induced elevation of the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in rats

Boyd, K. N., O'Buckley, T. K. & Leslie Morrow, A. Oct 2008 In : Alcoholism: Clinical and Experimental Research. 32, 10, p. 1774-1781 8 p.

Research output: Contribution to journalArticle

Acetaldehyde
Rats
Ethanol
Steroids
Cyanamide
2007
21 Citations

Acute ethanol administration rapidly increases phosphorylation of conventional protein kinase C in specific mammalian brain regions in vivo

Wilkie, M. B., Besheer, J., Kelley, S. P., Kumar, S., O'Buckley, T. K., Morrow, A. L. & Hodge, C. W. Jul 1 2007 In : Alcoholism: Clinical and Experimental Research. 31, 7, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinase C
Brain
Ethanol
Nucleus Accumbens